Abstract：
:Parameters of exploratory behaviors responsive to anti-anxiety drugs are reviewed with respect to their sensitivity and specificity for anxiolytics in mice. Mouse models appear to rest on a disinhibition of natural exploratory tendencies by anxiolytic treatments. Analysis of agonists of the brain benzodiazepine binding site, such as chlordiazepoxide and diazepam, significantly increase exploration of a hole-board, of a two-chambered light in equilibrium dark apparatus, increase social interaction under high levels of illumination, increase consumption of a novel food in an unfamiliar environment, and increase punished crossings in a footshock conflict paradigm. These tests detect anxiolytic responses at doses of benzodiazepines well within the clinically effective range. Pharmacological specificity was established for the hole-board and light in equilibrium transition tests, showing that non-anxiolytic categories of psychoactive drugs did not produce false positives. Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range. Analysis of antagonists of the brain benzodiazepine binding site did not show active antagonist properties in the light in equilibrium transitions model, although the antagonist Ro-15-1788 appeared to have partial agonist properties in the open field test, suggesting that rat models may be more sensitive to anxiogenic compounds than are mouse models. The wide separation between anxiolytic and sedative doses in mouse models recommend these exploration paradigms as good predictive screens for the testing of novel anxiolytic compounds.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Crawley JNdoi
10.1016/0149-7634(85)90030-2subject
Has Abstractpub_date
1985-04-01 00:00:00pages
37-44issue
1eissn
0149-7634issn
1873-7528journal_volume
9pub_type
杂志文章,评审abstract：:There are roughly 30-40 million HIV-infected individuals in the world as of December 2007, and drug abuse directly contributes to one-third of all HIV infections in the United States. Antiretroviral therapy has increased the lifespan of HIV-seropositives, but CNS function often remains diminished, effectively decreasi...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2008.01.004
更新日期：2008-07-01 00:00:00
abstract：:Water intake may or may not be associated with sodium appetite. There are excitatory and inhibitory mechanisms that control these behaviors whose mediators and interactions are unclear. We investigated the effects of specific antisera against angiotensin II (AB-AII) and atrial natriuretic peptide (AB-ANP) on the induc...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(96)00052-8
更新日期：1997-09-01 00:00:00
abstract：:Taste aversion learning (TAL) consists of the avoidance of a taste previously associated with a noxious visceral stimulus. Clinical and experimental studies suggest that this adaptive process can be established by different procedures that imply distinct forms of learning and memory, although the final result is analo...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2005.06.002
更新日期：2005-01-01 00:00:00
abstract：:The thalamus, with its cortical, subcortical, and cerebellar connections, is a critical node in networks supporting cognitive functions known to decline in normal aging, including component processes of memory and executive functions of attention and information processing. The macrostructure, microstructure, and neur...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2015.03.008
更新日期：2015-07-01 00:00:00
abstract：:Vulnerability to the development of drug-intake has been studied by using the acquisition of intravenous amphetamine self-administration in the rat. In a series of neurobiological experiments we provoked imbalances in the functioning of the dopaminergic (DA) network by performing lesions of the DA cell bodies in the v...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(89)80023-5
更新日期：1989-07-01 00:00:00
abstract：:Conditioned drug craving and withdrawal elicited by cues paired with drug use or acute withdrawal are among the many factors contributing to compulsive drug taking. Understanding how to stop these cues from having these effects is a major goal of addiction research. Extinction is a form of learning in which associatio...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2010.01.011
更新日期：2010-11-01 00:00:00
abstract：:Deep brain stimulation (DBS) is remarkably effective for a range of neurological and psychiatric disorders that have failed pharmacological and cell transplant therapies. Clinical investigations are underway for a variety of other conditions. Yet, the therapeutic mechanisms of action are unknown. In addition, DBS rese...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2007.06.003
更新日期：2008-01-01 00:00:00
abstract：:Yawning is a phylogenetically old behaviour that can be observed in most vertebrate species from foetal stages to old age. The origin and function of this conspicuous phenomenon have been subject to speculations for centuries. Here, we review the experimental evidence for each of these hypotheses. It is found that the...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.03.008
更新日期：2010-07-01 00:00:00
abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) modulate dopaminergic function. Discovery of their multiplicity has lead to the search for subtype-selective nAChR agonists that might be therapeutically beneficial in diseases linked to brain dopaminergic pathways. The regulation and responses of the nigrostriatal a...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2006.09.008
更新日期：2007-01-01 00:00:00
abstract：:Maternal obesity in pregnancy is associated with neurobehavioral problems in the offspring. Establishing causality has been challenging in existing human studies, due to confounding by genetic and postnatal environment. Animal experiments can improve our understanding of this association. This systematic review examin...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2018.12.023
更新日期：2019-03-01 00:00:00
abstract：:In this review, we have summarized various aspects as to how prenatal protein malnutrition affects development of the brain and have attempted to integrate several broad principles, concepts, and trends in this field in relation to our findings and other studies of malnutrition insults. Nutrition is probably the singl...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(05)80234-9
更新日期：1993-04-01 00:00:00
abstract：:Atypical behavioral responses to environmental sounds are common in autistic children and adults, with 50-70 % of this population exhibiting decreased sound tolerance (DST) at some point in their lives. This symptom is a source of significant distress and impairment across the lifespan, contributing to anxiety, challe...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.11.030
更新日期：2021-02-01 00:00:00
abstract：:Taurine is a highly abundant "amino acid" in the brain. Despite the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, n...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2017.09.008
更新日期：2017-12-01 00:00:00
abstract：:Despite a plethora of knowledge, both behavioural and neural, of the mechanisms defining space around a singular body little is known about the neural mechanisms that encode space between bodies. Yet, the space between people creates and defines the social dynamics of our interactions with others. This review brings t...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2008.09.007
更新日期：2009-03-01 00:00:00
abstract：:Modern functional imaging methods, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), provide non-invasive, quantitative tools for the direct measurement of neurotransmitter function in the living human brain. The dopamine system has been of key interest; first, because ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(02)00065-9
更新日期：2002-11-01 00:00:00
abstract：:Repetitive and stereotyped behavior is a prominent element of both animal and human behavior. Similar behavior is seen across species, in diverse neuropsychiatric disorders and in key phases of typical development. This raises the question whether these similar classes of behavior are caused by similar neurobiological...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.02.004
更新日期：2011-01-01 00:00:00
abstract：:If a segment of a line differs in luminance or color from the rest of the line, three illusory phenomena may be perceived: a reduction in contrast of the line segment relative to the background, subjective contours running perpendicularly to the ends of the line segment, and spread of color or brightness surrounding t...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(89)80047-8
更新日期：1989-04-01 00:00:00
abstract：:The question of how representational capacities develop in humans has been engaging cognitive psychologists for decades. Looking time studies have explored when infants start to show signs of perceiving and remembering the properties of specific objects at specific locations. Here we integrate these findings into the ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2004.01.002
更新日期：2004-04-01 00:00:00
abstract：:Positive associations between human intelligence and brain size have been suspected for more than 150 years. Nowadays, modern non-invasive measures of in vivo brain volume (Magnetic Resonance Imaging) make it possible to reliably assess associations with IQ. By means of a systematic review of published studies and unp...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2015.09.017
更新日期：2015-10-01 00:00:00
abstract：:Intranasal oxytocin has been shown to promote social functioning and has recently been applied as a treatment for autism spectrum disorders (ASD). The current meta-analysis aims to assess the crucial question of oxytocin's efficacy in the treatment of ASD. We performed a systematic literature search, including randomi...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.12.028
更新日期：2021-01-02 00:00:00
abstract：:One view of language origins sees it as ancient and selection-driven; the other as recent and emergent. Such disagreement occurs because language is ephemeral, detectable only by indirect proxies. Because internalized language and symbolic thought are tightly linked, the best archaeological proxies for language are sy...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2017.01.043
更新日期：2017-10-01 00:00:00
abstract：:Neurosteroids are potent and effective neuromodulators that are synthesized from cholesterol in the brain. These agents and their synthetic derivatives influence the function of multiple signaling pathways including receptors for γ-aminobutyric acid (GABA) and glutamate, the major inhibitory and excitatory neurotransm...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2012.10.005
更新日期：2013-01-01 00:00:00
abstract：:Tourette syndrome (TS) is a neurodevelopmental condition characterized by the presence of multiple tics. In addition to common behavioral co-morbidities such as obsessive-compulsive disorder and attention-deficit and hyperactivity disorder, patients with TS can present with self-injurious behavior (SIB): deliberate, n...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.03.022
更新日期：2020-06-01 00:00:00
abstract：:Human typical life history involves specific tradeoffs, resulting in the selection of specific cognitive adaptations, among which a suite of age- and gender-specific precaution systems sensitive to variations in the physical and social environment. Precaution systems take into account the individual's status and life-...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.09.007
更新日期：2011-03-01 00:00:00
abstract：:Empathy is considered a cornerstone of human social experience, and as such has been widely investigated from psychological and neuroscientific approaches. To better understand the factors influencing individual differences in empathy, we reviewed and meta-analyzed the behavioral genetic literature of emotional empath...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.03.023
更新日期：2020-07-01 00:00:00
abstract：:The long-term administration of neuroleptics causes tardive dyskinesia, which closely resembles levodopa-induced dyskinesias, and is brought about through complex mechanisms which are ill-defined. It is generally believed that the pathogenesis of tardive dyskinesia relates closely to the chronic blockade of dopamine r...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(88)80039-3
更新日期：1988-10-01 00:00:00
abstract：:The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-f...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.12.011
更新日期：2017-02-01 00:00:00
abstract：:To improve the translational predictability of treatment strategies for Huntington's disease (HD), sensitive and analogous cognitive outcomes are needed across HD animal models and humans. Spatial memory measures are promising candidates because they are based on 'visual' or 'non-verbal' cognition, and are commonly te...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2019.01.015
更新日期：2019-03-01 00:00:00
abstract：:At present there is no direct brain measure of basic emotional dynamics from the human brain. EEG provides non-invasive approaches for monitoring brain electrical activity to emotional stimuli. Event-related desynchronization/synchronization (ERD/ERS) analysis, based on power shifts in specific frequency bands, has so...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2011.05.001
更新日期：2011-10-01 00:00:00
abstract：:Paradoxical sleep in rats, cats and mice is usually preceded and sometimes followed by a short-lasting (a few seconds) electroencephalogram (EEG) stage characterized by high-amplitude spindles in the anterior cortex and low-frequency theta rhythm in the dorsal hippocampus. The former is an index of advanced slow-wave ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(95)00055-0
更新日期：1996-10-01 00:00:00
