Abstract:
:Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show here that it is nevertheless possible to extract the properties of the events and, in particular, to extract the event rate, the synaptic time constants, and the properties of the event size distribution from in vivo voltage-clamp recordings. Applied to cerebellar interneurons, our method reveals that the synaptic input rate increases from 600 Hz during rest to 1000 Hz during locomotion, while the amplitude and shape of the synaptic events are unaffected by this state change. This method thus complements existing methods to measure neural function in vivo.
journal_name
Neural Computjournal_title
Neural computationauthors
Puggioni P,Jelitai M,Duguid I,van Rossum MCWdoi
10.1162/NECO_a_00975subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1745-1768issue
7eissn
0899-7667issn
1530-888Xjournal_volume
29pub_type
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