Extraction of Synaptic Input Properties in Vivo.

Abstract:

:Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show here that it is nevertheless possible to extract the properties of the events and, in particular, to extract the event rate, the synaptic time constants, and the properties of the event size distribution from in vivo voltage-clamp recordings. Applied to cerebellar interneurons, our method reveals that the synaptic input rate increases from 600 Hz during rest to 1000 Hz during locomotion, while the amplitude and shape of the synaptic events are unaffected by this state change. This method thus complements existing methods to measure neural function in vivo.

journal_name

Neural Comput

journal_title

Neural computation

authors

Puggioni P,Jelitai M,Duguid I,van Rossum MCW

doi

10.1162/NECO_a_00975

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

1745-1768

issue

7

eissn

0899-7667

issn

1530-888X

journal_volume

29

pub_type

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