Local and global gating of synaptic plasticity.

Abstract:

:Mechanisms influencing learning in neural networks are usually investigated on either a local or a global scale. The former relates to synaptic processes, the latter to unspecific modulatory systems. Here we study the interaction of a local learning rule that evaluates coincidences of pre- and postsynaptic action potentials and a global modulatory mechanism, such as the action of the basal forebrain onto cortical neurons. The simulations demonstrate that the interaction of these mechanisms leads to a learning rule supporting fast learning rates, stability, and flexibility. Furthermore, the simulations generate two experimentally testable predictions on the dependence of backpropagating action potential on basal forebrain activity and the relative timing of the activity of inhibitory and excitatory neurons in the neocortex.

journal_name

Neural Comput

journal_title

Neural computation

authors

Sánchez-Montañés MA,Verschure PF,König P

doi

10.1162/089976600300015682

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

519-29

issue

3

eissn

0899-7667

issn

1530-888X

journal_volume

12

pub_type

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