Variations on the Theme of Synaptic Filtering: A Comparison of Integrate-and-Express Models of Synaptic Plasticity for Memory Lifetimes.

Abstract:

:Integrate-and-express models of synaptic plasticity propose that synapses integrate plasticity induction signals before expressing synaptic plasticity. By discerning trends in their induction signals, synapses can control destabilizing fluctuations in synaptic strength. In a feedforward perceptron framework with binary-strength synapses for associative memory storage, we have previously shown that such a filter-based model outperforms other, nonintegrative, "cascade"-type models of memory storage in most regions of biologically relevant parameter space. Here, we consider some natural extensions of our earlier filter model, including one specifically tailored to binary-strength synapses and one that demands a fixed, consecutive number of same-type induction signals rather than merely an excess before expressing synaptic plasticity. With these extensions, we show that filter-based models outperform nonintegrative models in all regions of biologically relevant parameter space except for a small sliver in which all models encode memories only weakly. In this sliver, which model is superior depends on the metric used to gauge memory lifetimes (whether a signal-to-noise ratio or a mean first passage time). After comparing and contrasting these various filter models, we discuss the multiple mechanisms and timescales that underlie both synaptic plasticity and memory phenomena and suggest that multiple, different filtering mechanisms may operate at single synapses.

journal_name

Neural Comput

journal_title

Neural computation

authors

Elliott T

doi

10.1162/NECO_a_00889

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

2393-2460

issue

11

eissn

0899-7667

issn

1530-888X

journal_volume

28

pub_type

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