Changes in GABAB modulation during a theta cycle may be analogous to the fall of temperature during annealing.

Abstract:

:Changes in GABA modulation may underlie experimentally observed changes in the strength of synaptic transmission at different phases of the theta rhythm (Wyble, Linster, & Hasselmo, 1997). Analysis demonstrates that these changes improve sequence disambiguation by a neural network model of CA3. We show that in the framework of Hopfield and Tank (1985), changes in GABA suppression correspond to changes in the effective temperature and the relative energy of data terms and constraints of an analog network. These results suggest that phasic changes in the activity of inhibitory interneurons during a theta cycle may produce dynamics that resemble annealing. These dynamics may underlie a role for the theta cycle in improving sequence retrieval for spatial navigation.

journal_name

Neural Comput

journal_title

Neural computation

authors

Sohal VS,Hasselmo ME

doi

10.1162/089976698300017539

subject

Has Abstract

pub_date

1998-05-15 00:00:00

pages

869-82

issue

4

eissn

0899-7667

issn

1530-888X

journal_volume

10

pub_type

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