Abstract:
:Recent experiments indicate that the calcium store (e.g., endoplasmic reticulum) is involved in electrical bursting and [Ca2+]i oscillation in bursting neuronal cells. In this paper, we formulate a mathematical model for bursting neurons, which includes Ca2+ in the intracellular Ca2+ stores and a voltage-independent calcium channel (VICC). This VICC is activated by a depletion of Ca2+ concentration in the store, [Ca2+]cs. In this model, [Ca2+]cs oscillates slowly, and this slow dynamic in turn gives rise to electrical bursting. The newly formulated model thus is radically different from existing models of bursting excitable cells, whose mechanism owes its origin to the ion channels in the plasma membrane and the [Ca2+]i dynamics. In addition, this model is capable of providing answers to some puzzling phenomena, which the previous models could not (e.g., why cAMP, glucagon, and caffeine have ability to change the burst periodicity). Using mag-fura-2 fluorescent dyes, it would be interesting to verify the prediction of the model that (1) [Ca2+]cs oscillates in bursting neurons such as Aplysia neuron and (2) the neurotransmitters and hormones that affect the adenylate cyclase pathway can influence this oscillation.
journal_name
Neural Computjournal_title
Neural computationauthors
Chay TRdoi
10.1162/neco.1996.8.5.951subject
Has Abstractpub_date
1996-07-01 00:00:00pages
951-78issue
5eissn
0899-7667issn
1530-888Xjournal_volume
8pub_type
杂志文章abstract::How do multiple feature maps that coexist in the same region of cerebral cortex align with each other? We hypothesize that such alignment is governed by temporal correlations: features in one map that are temporally correlated with those in another come to occupy the same spatial locations in cortex over time. To exam...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.1996.8.4.731
更新日期:1996-05-15 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976699300016160
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00072
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journal_title:Neural computation
pub_type: 杂志文章
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journal_title:Neural computation
pub_type: 杂志文章
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976698300017160
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.2007.19.9.2557
更新日期:2007-09-01 00:00:00
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更新日期:2014-10-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976602753712972
更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1162/0899766054026693
更新日期:2005-08-01 00:00:00
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journal_title:Neural computation
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更新日期:2000-10-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章,评审
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更新日期:2005-04-01 00:00:00
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journal_title:Neural computation
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pub_type: 杂志文章
doi:10.1162/NECO_a_00012
更新日期:2010-09-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.2008.12-06-416
更新日期:2008-10-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章,评审
doi:10.1162/089976698300017836
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pub_type: 杂志文章
doi:10.1162/089976600300015150
更新日期:2000-08-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00479
更新日期:2013-09-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/0899766041336396
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journal_title:Neural computation
pub_type: 信件
doi:10.1162/NECO_a_00840
更新日期:2016-06-01 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章,评审
doi:10.1162/neco.1997.9.4.701
更新日期:1997-05-15 00:00:00
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更新日期:1998-11-15 00:00:00
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journal_title:Neural computation
pub_type: 杂志文章
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