Conductance-based integrate-and-fire models.

Abstract:

:A conductance-based model of Na+ and K+ currents underlying action potential generation is introduced by simplifying the quantitative model of Hodgkin and Huxley (HH). If the time course of rate constants can be approximated by a pulse, HH equations can be solved analytically. Pulse-based (PB) models generate action potentials very similar to the HH model but are computationally faster. Unlike the classical integrate-and-fire (IAF) approach, they take into account the changes of conductances during and after the spike, which have a determinant influence in shaping neuronal responses. Similarities and differences among PB, IAF, and HH models are illustrated for three cases: high-frequency repetitive firing, spike timing following random synaptic inputs, and network behavior in the presence of intrinsic currents.

journal_name

Neural Comput

journal_title

Neural computation

authors

Destexhe A

doi

10.1162/neco.1997.9.3.503

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

503-14

issue

3

eissn

0899-7667

issn

1530-888X

journal_volume

9

pub_type

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