Abstract:
AIM:To study the impact of the genes of donor killer cell immunoglobulin-like receptors (KIR) and HLA-KIR ligands on overall (OS) and event-free survival (EFS) rates in patients with myeloid leukemia after transplantation with allogeneic hematopoietic stem cells (allo-HSCT) from HLA-identical related and HLA-compatible unrelated donors. SUBJECTS AND METHODS:The investigation enrolled 29 patients who had undergone allo-HSCT from KIR-genotyped donors at the Department of Bone Marrow Transplantation, Hematology Research Center (see symbol) in 2010-2013. OS and EFS rates after allo-HSCT were calculated using the Kaplan-Meier method. RESULTS:The main predictor of recurrence and survival in patients after allo-HSCT was a recurrence-risk group the patient belonged to before transplantation. The standard-risk group patients whose donors had telomeric gene-content motifs of KIR-B haplotypes had higher EFS rates than those whose donors lacked these genes. The standard-risk patients homozygous for HLA-1 alleles (i.e. without HLA-C2 ligand) tended to have higher EFS rates, so did the patients without HLA-Bw4 ligand. CONCLUSION:The donors having telomeric gene-content motifs of KIR-B haplotypes are more preferred for allo-HSCT for patients with myeloid leukemia as the presence of donor telomeric KIR-B genes increases EFS rates in standard-risk patients. :Цель исследования. Изучить влияние генов киллерных иммуноглобулиноподобных рецепторов (KIR) донора и лигандов HLA-KIR на общую (ОВ) и бессобытийную (БСВ) выживаемость у больных миелоидными лейкозами после трансплантации аллогенных гемопоэтических стволовых клеток (алло-ТГСК) от идентичных по HLA родственных и совместимых по HLA неродственных доноров. Материалы и методы. В исследование включили 29 больных, которым в 2010-2013 гг. в отделении трансплантации костного мозга Гематологического научного центра выполнена алло-ТГСК от генотипированных по KIR доноров. ОВ и БСВ после алло-ТГСК рассчитывали по методу Каплана-Мейера. Результаты. Основной фактор прогноза вероятности рецидива и продолжительности жизни пациентов после алло-ТГСК - группа риска развития рецидива, к которой относился больной перед трансплантацией. Больные из группы стандартного риска, доноры которых обладали генами теломерной части KIR-B-гаплотипов, имели более высокую БСВ по сравнению с больными, доноры которых не обладали этими генами. Отмечена тенденция к более высокой БСВ у больных со стандартным риском, гомозиготных по аллелям лигандов HLA-C1 (т.е. без лигандов HLA-C2), и тенденция к более высокой БСВ у больных без лигандов HLA-Bw4. Заключение. Доноры, обладающие генами теломерной части KIR-В-гаплотипов, более предпочтительны для алло-ТГСК больным миелоидными лейкозами, так как наличие генов теломерной области KIR-В-гаплотипов у донора повышает БСВ у больных со стандартным риском.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Khamaganova EG,Parovichnikova EN,Kuzmina LA,Kulikov SM,Savchenko VGdoi
10.17116/terarkh2015871168-77subject
Has Abstractpub_date
2015-01-01 00:00:00pages
68-77issue
11eissn
0040-3660issn
2309-5342journal_volume
87pub_type
杂志文章abstract::Altogether 72 patients with different variants of a course of fibrous-cavernous pulmonary tuberculosis were investigated for the presence of HLA antigens and Hp phenotypes. It was shown that an increase in the frequency of antigen DR2 and Hp 2-2 could be used as a prognostic prerequisite in the assessment of a course ...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:AIM:To evaluate the effect of sitagliptin in combination with metformin on glucose toxicity and lipotoxicity in patients with type 2 diabetes mellitus. SUBJECTS AND METHODS:. Eighty-two overweight and dyslipidemic patients (mean age 55.3 +/- 9.1 years) who had not achieved the goal levels of glycated hemoglobin (HbA1c...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-01-01 00:00:00
abstract:AIM:To examine changes in the structure of large (carotid and femoral) arteries at an early stage of chronic renal failure (CRF) and factors significant for their development. MATERIAL AND METHODS:Duplex ultrasonography of the common carotid arteries (CCA) and common femoral arteries (CFA), serum biochemical tests, ec...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Seventy patients with pectus carinatum were examined. All the patients demonstrated the minimal signs of connective tissue deficiency. The ECG readings showed incomplete blockade of the bundle of His, ventricular extrasystole, WPW and CLC syndromes, and metabolic alterations in the myocardium. Mitral valve prolapse wa...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are most commonly used to treat acute and chronic pain in locomotor system (LMS) diseases. However, their administration may be accompanied by the development of dangerous complications as organic and functional disorders of the cardiovascular system (CVS) and gastrointest...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章,评审
doi:
更新日期:2014-01-01 00:00:00
abstract:AIM:To comprehensively study of the function of digestive organs in cholelithiasis (CL). SUBJECTS AND METHODS:Three hundred and seventeen patients with the early (prestone) stage of CL were examined. The latter was verified by ultrasonography (USG) and biochemical bile tests. The patients underwent pH metry and esopha...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.17116/terarkh201587254-58
更新日期:2015-01-01 00:00:00
abstract:AIM:To study characteristics of iron deficiency anemia (IDA) in native population of high altitude territories. MATERIAL AND METHODS:1300 women living in Tien-Shan areas were examined for serum and erythrocytic ferritins (SF and EF), general iron-binding capacity of the serum, transferrin saturation with iron, transfe...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:AIM:To investigate the transcription factor pSTAT3 in overweight asthmatics on a model of peripheral blood mononuclear cells at baseline and during recombinant leptin modulation. MATERIAL AND METHODS:A flow fluorometric assay was used according to the standard Bio-Plex protocol on a Bio-Plex immunoanalyzer (a flow flu...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.17116/terarkh201789348-53
更新日期:2017-01-01 00:00:00
abstract::Na+/H+ countertransport speed in red cells of insulin-dependent diabetes (IDDM) patients was studied. The rate of Na+/H+ exchange in diabetic erythrocytes did not differ statistically from the rate of such exchange in control erythrocytes. Statistically significant differences in the rates of Na+/H+ exchange in red ce...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Uncontrolled hypercoagulation and inflammation (thromboinflammation), which are both independent and closely related and amplifying each other pathological processes, form the basis for pathogenesis of a wide range of diseases and complications, including immuno-inflammatory (autoimmune) rheumatic diseases, with the d...
journal_title:Terapevticheskii arkhiv
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doi:10.26442/00403660.2020.05.000697
更新日期:2020-06-05 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The correlation of indices of the phase structure of the left ventricular systole in patients with isolated left ventricular (140 patients) and combined biventricular (60 patients) myocardial infarction showed prolonged tension time resulting from isometric contraction, and a great difference between the actual and pr...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::A total of 108 patients with peptic ulcer were entered into the study. Examination of the microcirculation in the eye conjunctiva and microvessels of biopsy specimens of the mucous membrane taken from ulcerous areas revealed that disease relapses were marked by pronounced disorders of the end blood flow. The extent of...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Biological methods are widely used in the treatment of intestinal inflammation (II). The TNFalpha inhibitor infliximab can quickly correct recurrence, provide long-term remission and reduce hormone need in many patients with hormone-resistant and hormone-dependent forms of Crohn's disease (CD) and ulcerative colitis (...
journal_title:Terapevticheskii arkhiv
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doi:
更新日期:2011-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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更新日期:2007-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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doi:10.26442/00403660.2019.08.000379
更新日期:2019-08-15 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Hemocoagulation was examined in 477 diabetes mellitus patients. Whatever the disease type, severity, duration and the intensity of microvascular complications, diabetes mellitus was discovered to be marked by the development of chronic intravascular blood microcoagulation associated with primary hyperactivation of the...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::A total of 59 bird fanciers suffering from alveolitis were examined, of them 23 with alveolitis of bronchitis type, 24 with alveolitis of pneumonic type and 11 alveolitis of fibrosing type. In all 3 variants of a course of alveolitis the obstructive syndrome was the main sign of functional disturbances. Intrapulmonary...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:10.26442/00403660.2020.08.000765
更新日期:2020-09-03 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
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