Abstract：
OBJECTIVE:We investigated the expression of annexin A5 (ANXA5) in human cholangiocarcinoma (CCA) cell line and its effect on proliferation, migration, and apoptosis of human CCA cells. MATERIALS AND METHODS:Expression of ANXA5 was detected by fluorescent quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and western blotting method in 2 human CCA cell lines, QBC939 and RBE. 3 shRNA plasmids for ANXA5 silencing (ANXA5-sh1, ANXA5-sh2, ANXA5-sh3) and 1 negative control plasmid were constructed to infect QBC939 cells. The infection efficiency, expression of ANXA5, apoptosis and cell cycle of QBC939 cell were measured separately. RESULTS:The expression of ANXA5 in QBC939 cell was significantly higher than RBE cell. Expressed ANXA5 protein in the QBC939-KD cell (QBC939 cell treated by RNAi) was significantly lower than QBC939-BC (QBC939 cell) and QBC939-NC cells (QBC939 cell treated by scramble plasmid). The ratio of G0/1 phase cells and apoptosis rate increased in QBC939-KD cell. The proliferation activity and invasion ability decreased in QBC939-KD cell compared with QBC939-NC and QBC939-BC cells. CONCLUSIONS:ANXA5 play important role in the migration and apoptosis of CCA cells. Inhibiting the expression of ANXA5 significantly reduce the proliferation, migration and invasion ability of QBC939 cells, and increase the apoptosis of QBC939 cells.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Ding XM,Li JX,Wang K,Wu ZS,Yao AH,Jiao CY,Qian JJ,Bai DS,Li XCsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
1477-1488issue
7eissn
1128-3602issn
2284-0729journal_volume
21pub_type
杂志文章abstract：OBJECTIVE:The aim of the study was to investigate the influences of micro ribonucleic acid (miR)-21 and downstream Toll-like receptor 4 (TLR4)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway on myocardial apoptosis induced by myocardial ischemia-reperfusion (I/R) injury in rats. MATERIAL...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201811_16420
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abstract：OBJECTIVE:Glioma is a common aggressive cancer and a major public health problem worldwide, with high incidence, recurrence, and mortality. Circular RNA (circRNA) has been reported to be involved in glioma, but the role of circ_0079593 in glioma is still unclear. MATERIALS AND METHODS:The real-time quantitative polyme...
journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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更新日期：2016-12-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：10.26355/eurrev_202007_21909
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doi：10.26355/eurrev_202012_24047
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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更新日期：2016-04-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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更新日期：2016-01-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2017-09-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2005-11-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2013-07-01 00:00:00
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doi：
更新日期：2011-06-01 00:00:00
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doi：10.26355/eurrev_202007_21874
更新日期：2020-07-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201811_16261
更新日期：2018-11-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：10.26355/eurrev_201805_15053
更新日期：2018-05-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2017-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：10.26355/eurrev_202011_23580
更新日期：2020-11-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2014-08-01 00:00:00
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doi：10.26355/eurrev_201903_17270
更新日期：2019-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201711_13835
更新日期：2017-11-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202009_22821
更新日期：2020-09-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202011_23847
更新日期：2020-11-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201803_14464
更新日期：2018-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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更新日期：2020-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201903_17411
更新日期：2019-03-01 00:00:00
