Abstract:
:In vitro and in vivo study results were reviewed from cefmetazole, a "new" parenteral cephamycin. Cefmetazole's spectrum of activity was comparable to that of second-generation cephalosporins, which includes clinical coverage of many Enterobacteriaceae, Staphylococcus spp., streptococci, Haemophilus spp., pathogenic Neisseria, Branhamella catarrhalis, and anaerobic bacteria. Cefmetazole was generally more potent (two- to eightfold) than cefoxitin against organisms within their spectrums and was particularly active for staphylococci (MIC90, 2.0 micrograms/ml). Methicillin-resistant S. aureus strains were more susceptible to cefmetazole alone or in combination (fosfomycin) than any other cephamycin. Cefmetazole has demonstrated excellent stability to aerobic and anaerobic organism-produced beta-lactamases. It also inhibits Type I cephalosporinases and, uniquely, some other cephalosporinases produced by the Bacteroides. This superior stability, enzyme interaction, and better penetration into bacterial cells results in a sustained bactericidal effect and a capacity for more infrequent dosing. The cefmetazole serum elimination half-life was 1.5 hr, also justifying use at greater than or equal to 8-hr intervals. Clinical trials in the United States and Japan demonstrated an acceptably high cefmetazole infection cure rate (88% to 100%), especially in direct comparative studies with cefoxitin. Cefmetazole was also proven very effective in minimizing infectious wound morbidity (prophylaxis) using 2 g single- or multidose regimens. Adverse drug reactions were usually minor; in the Japanese surveillance trial (118,318 patients) the rate was only 2.2% (8.8% in United States). Cefmetazole has been extensively and safely used in Japan since 1980.
journal_name
Diagn Microbiol Infect Disjournal_title
Diagnostic microbiology and infectious diseaseauthors
Jones RNdoi
10.1016/0732-8893(89)90106-5subject
Has Abstractpub_date
1989-09-01 00:00:00pages
367-79issue
5eissn
0732-8893issn
1879-0070pii
0732-8893(89)90106-5journal_volume
12pub_type
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
pub_type: 杂志文章,随机对照试验
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
pub_type: 杂志文章
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journal_title:Diagnostic microbiology and infectious disease
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