Abstract:
:Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns.
journal_name
Med Image Analjournal_title
Medical image analysisauthors
Sudre CH,Cardoso MJ,Ourselin S,Alzheimer’s Disease Neuroimaging Initiative.doi
10.1016/j.media.2017.02.007subject
Has Abstractpub_date
2017-05-01 00:00:00pages
50-64eissn
1361-8415issn
1361-8423pii
S1361-8415(17)30025-7journal_volume
38pub_type
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