Longitudinal segmentation of age-related white matter hyperintensities.

Abstract:

:Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns.

journal_name

Med Image Anal

journal_title

Medical image analysis

authors

Sudre CH,Cardoso MJ,Ourselin S,Alzheimer’s Disease Neuroimaging Initiative.

doi

10.1016/j.media.2017.02.007

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

50-64

eissn

1361-8415

issn

1361-8423

pii

S1361-8415(17)30025-7

journal_volume

38

pub_type

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