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Angiogenic characteristics of human stromal vascular fraction in ischemic hindlimb.

Abstract：

INTRODUCTION:In this study, we sought to characterize the angio-vasculogenic property of human adipose tissue-derived stromal vascular fraction (SVF) and to determine the therapeutic potential of SVF in the context of experimental ischemia. Although human SVF is used for cell therapy, its angiogenic and vasculogenic characteristics have not been fully elucidated. METHODS AND RESULTS:We conducted flow cytometry, microarray, quantitative (q)-PCR, Matrigel tube formation assays and in vivo therapeutic assays using an ischemic hind limb mouse model. Gene/micro RNA microarray, quantitative (q)-PCR results revealed that the representative pro-angiogenic factors were highly upregulated in SVF compared with human adipose-derived mesenchymal stem cells (ASCs). In addition, SVF exhibited high expression of endothelium-specific genes and showed robust in vitro micro-vascular formation. SVF was transplanted into ischemic mouse hind limbs and compared with ASC transplantation. SVF transplantation prevented limb loss and augmented blood perfusion, indicating that SVF promotes neovascularization in hind limb ischemia. Transplanted SVF showed high vasculogenic potential in vivo compared with transplanted ASCs. CONCLUSIONS:Our data indicate that SVF has remarkable therapeutic effects on hind limb ischemia via robust angiogenic and vasculogenic activity.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Jin E,Chae DS,Son M,Kim SW

doi

10.1016/j.ijcard.2017.02.080

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

38-47

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)31109-9

journal_volume

234

pub_type

杂志文章

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