A Novel MSCRAMM Subfamily in Coagulase Negative Staphylococcal Species.

Abstract:

:Coagulase negative staphylococci (CoNS) are important opportunistic pathogens. Staphylococcus epidermidis, a coagulase negative staphylococcus, is the third leading cause of nosocomial infections in the US. Surface proteins like Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) are major virulence factors of pathogenic gram positive bacteria. Here, we identified a new chimeric protein in S. epidermidis, that we call SesJ. SesJ represents a prototype of a new subfamily of MSCRAMMs. Structural predictions show that SesJ has structural features characteristic of a MSCRAMM along with a N-terminal repeat region and an aspartic acid containing C-terminal repeat region, features that have not been previously observed in staphylococcal MSCRAMMs but have been found in other surface proteins from gram positive bacteria. We identified and analyzed structural homologs of SesJ in three other CoNS. These homologs of SesJ have an identical structural organization but varying sequence identities within the domains. Using flow cytometry, we also show that SesJ is expressed constitutively on the surface of a representative S. epidermidis strain, from early exponential to stationary growth phase. Thus, SesJ is positioned to interact with protein targets in the environment and plays a role in S. epidermidis virulence.

journal_name

Front Microbiol

authors

Arora S,Uhlemann AC,Lowy FD,Hook M

doi

10.3389/fmicb.2016.00540

subject

Has Abstract

pub_date

2016-04-29 00:00:00

pages

540

issn

1664-302X

journal_volume

7

pub_type

杂志文章
  • Replicon-Based Typing of IncI-Complex Plasmids, and Comparative Genomics Analysis of IncIγ/K1 Plasmids.

    abstract::IncI-complex plasmids can be divided into seven subgroups IncI1, IncI2, IncIγ, IncB/O, IncK1, IncK2, and IncZ. In this study, a replicon-based scheme was proposed for typing IncI-complex plasmids into four separately clustering subgroups IncI2, IncI1/B/O, IncIγ/K1 and IncK2/Z, the last three of which were combined fro...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00048

    authors: Zhang D,Zhao Y,Feng J,Hu L,Jiang X,Zhan Z,Yang H,Yang W,Gao B,Wang J,Li J,Yin Z,Zhou D

    更新日期:2019-01-29 00:00:00

  • A New Method to Correct for Habitat Filtering in Microbial Correlation Networks.

    abstract::Amplicon sequencing of 16S, ITS, and 18S regions of microbial genomes is a commonly used first step toward understanding microbial communities of interest for human health, agriculture, and the environment. Correlation network analysis is an emerging tool for investigating the interactions within these microbial commu...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00585

    authors: Brisson V,Schmidt J,Northen TR,Vogel JP,Gaudin A

    更新日期:2019-03-20 00:00:00

  • Sequelae of Fetal Infection in a Non-human Primate Model of Listeriosis.

    abstract::Listeria monocytogenes (Lm) is a common environmental bacterium that thrives on vegetation and soil matter, but can infect humans if contaminated food products are ingested, resulting in severe disease in immunosuppressed populations, including pregnant women and newborns. To better understand how the unique immunolog...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02021

    authors: Wolfe B,Kerr AR,Mejia A,Simmons HA,Czuprynski CJ,Golos TG

    更新日期:2019-09-11 00:00:00

  • Characterization and Bio-Typing of Multidrug Resistance Plasmids From Uropathogenic Escherichia coli Isolated From Clinical Setting.

    abstract::Urinary tract infection is primarily caused by Escherichia coli. Multidrug resistance and their rapid dissemination in this pathogenic microbe complicate therapeutic strategies and threaten public health. Conjugation systems responsible for interbacterial transmission of antibiotic resistance are plasmid-encoded and c...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02913

    authors: Mukherjee SK,Mukherjee M

    更新日期:2019-12-18 00:00:00

  • Two Major Clades of Bradyrhizobia Dominate Symbiotic Interactions with Pigeonpea in Fields of Côte d'Ivoire.

    abstract::In smallholder farms of Côte d'Ivoire, particularly in the northeast of the country, Cajanus cajan (pigeonpea) has become an important crop because of its multiple beneficial facets. Pigeonpea seeds provide food to make ends meet, are sold on local markets, and aerial parts serve as forage for animals. Since it fixes ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01793

    authors: Fossou RK,Ziegler D,Zézé A,Barja F,Perret X

    更新日期:2016-11-11 00:00:00

  • Collective Vortex-Like Movement of Bacillus subtilis Facilitates the Generation of Floating Biofilms.

    abstract::Bacteria in nature are usually found in complex multicellular structures, called biofilms. One common form of a biofilm is pellicle-a floating mat of bacteria formed in the water-air interphase. So far, our knowledge on the basic mechanisms underlying the formation of biofilms at air-liquid interfaces is not complete....

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00590

    authors: Steinberg N,Rosenberg G,Keren-Paz A,Kolodkin-Gal I

    更新日期:2018-03-29 00:00:00

  • Correlation of rpoB Mutations with Minimal Inhibitory Concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS Endemic Setting, South Africa.

    abstract::Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recommended for HIV patients concurrently receiving protease inhibitors because of red...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01947

    authors: Rukasha I,Said HM,Omar SV,Koornhof H,Dreyer AW,Musekiwa A,Moultrie H,Hoosen AA,Kaplan G,Fallows D,Ismail N

    更新日期:2016-12-05 00:00:00

  • Importance of Promyelocytic Leukema Protein (PML) for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.

    abstract::Many DNA virus replication-related proteins are associated with promyelocytic leukemia protein (PML), a component of nuclear domain 10 (ND10), which has been investigated for its potential involvement in viral replication. In the case of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic gene products, K8 (K-bZIP), ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02324

    authors: Hossain MG,Ohsaki E,Honda T,Ueda K

    更新日期:2018-10-08 00:00:00

  • Impacts of Fertilization Regimes on Arbuscular Mycorrhizal Fungal (AMF) Community Composition Were Correlated with Organic Matter Composition in Maize Rhizosphere Soil.

    abstract::The understanding of the response of arbuscular mycorrhizal fungi (AMF) community composition to fertilization is of great significance in sustainable agriculture. However, how fertilization influences AMF diversity and composition is not well-established yet. A field experiment located in northeast China in typical b...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01840

    authors: Zhu C,Ling N,Guo J,Wang M,Guo S,Shen Q

    更新日期:2016-11-16 00:00:00

  • Actin and DNA Protect Histones from Degradation by Bacterial Proteases but Inhibit Their Antimicrobial Activity.

    abstract::Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis, and infection - induced cell death, histones are released from the cell. The extracellular histones have strong antimicrobial activity but are also cy...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01248

    authors: Sol A,Skvirsky Y,Blotnick E,Bachrach G,Muhlrad A

    更新日期:2016-08-09 00:00:00

  • Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections.

    abstract::Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant threat due to a lack of vaccines and affordable treatment options. The immune correlates of protecti...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2014.00690

    authors: Manickam C,Reeves RK

    更新日期:2014-12-08 00:00:00

  • The giant ciliate Zoothamnium niveum and its thiotrophic epibiont Candidatus Thiobios zoothamnicoli: a model system to study interspecies cooperation.

    abstract::Symbioses between chemoautotrophic sulfur-oxidizing (thiotrophic) bacteria and protists or animals are among the most diverse and prevalent in the ocean. They are extremely difficult to maintain in aquaria and no thiotrophic symbiosis involving an animal host has ever been successfully cultivated. In contrast, we have...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2014.00145

    authors: Bright M,Espada-Hinojosa S,Lagkouvardos I,Volland JM

    更新日期:2014-04-07 00:00:00

  • Vesicles From Vibrio cholerae Contain AT-Rich DNA and Shorter mRNAs That Do Not Correlate With Their Protein Products.

    abstract::Extracellular vesicles secreted by Gram-negative bacteria have proven to be important in bacterial defense, communication and host-pathogen relationships. They resemble smaller versions of the bacterial mother cell, with similar contents of proteins, LPS, DNA, and RNA. Vesicles can elicit a protective immune response ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02708

    authors: Langlete P,Krabberød AK,Winther-Larsen HC

    更新日期:2019-11-22 00:00:00

  • Bacterial Active Community Cycling in Response to Solar Radiation and Their Influence on Nutrient Changes in a High-Altitude Wetland.

    abstract::Microbial communities inhabiting high-altitude spring ecosystems are subjected to extreme changes in solar irradiance and temperature throughout the diel cycle. Here, using 16S rRNA gene tag pyrosequencing (cDNA) we determined the composition of actively transcribing bacteria from spring waters experimentally exposed ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01823

    authors: Molina V,Hernández K,Dorador C,Eissler Y,Hengst M,Pérez V,Harrod C

    更新日期:2016-11-17 00:00:00

  • Long-Term Oil Contamination Alters the Molecular Ecological Networks of Soil Microbial Functional Genes.

    abstract::With knowledge on microbial composition and diversity, investigation of within-community interactions is a further step to elucidate microbial ecological functions, such as the biodegradation of hazardous contaminants. In this work, microbial functional molecular ecological networks were studied in both contaminated a...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00060

    authors: Liang Y,Zhao H,Deng Y,Zhou J,Li G,Sun B

    更新日期:2016-02-03 00:00:00

  • Evaluation of MALDI-ToF Mass Spectrometry for Rapid Detection of Cereulide From Bacillus cereus Cultures.

    abstract::Bacillus cereus plays an often unrecognized role in food borne diseases. Food poisoning caused by this pathogen is manifested by either diarrhea or emesis. Due to the relatively high prevalence of emetic toxin cereulide associated food poisoning, methods for simple and reliable detection of cereulide producing strains...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.511674

    authors: Doellinger J,Schneider A,Stark TD,Ehling-Schulz M,Lasch P

    更新日期:2020-10-06 00:00:00

  • Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E. coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model.

    abstract::Rapidly changing concentrations of substrates frequently occur during large-scale microbial cultivations. These changing conditions, caused by large mixing times, result in a heterogeneous population distribution. Here, we present a powerful and efficient modeling approach to predict the influence of varying substrate...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01195

    authors: Nieß A,Löffler M,Simen JD,Takors R

    更新日期:2017-06-28 00:00:00

  • Genomic and Transcriptomic Insights into Calcium Carbonate Biomineralization by Marine Actinobacterium Brevibacterium linens BS258.

    abstract::Calcium carbonate (CaCO3) biomineralization has been investigated due to its wide range of scientific and technological implications, however, the molecular mechanisms of this important geomicrobiological process are largely unknown. Here, a urease-positive marine actinobacterium Brevibacterium linens BS258 was demons...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00602

    authors: Zhu Y,Ma N,Jin W,Wu S,Sun C

    更新日期:2017-04-06 00:00:00

  • Citrus Leprosis Virus C Encodes Three Proteins With Gene Silencing Suppression Activity.

    abstract::Citrus leprosis virus C (CiLV-C) belongs to the genus Cilevirus, family Kitaviridae, and is considered the most devastating virus infecting citrus in Brazil, being the main viral pathogen responsible for citrus leprosis (CL), a severe disease that affects citrus orchards in Latin America. Here, proteins encoded by CiL...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01231

    authors: Leastro MO,Castro DYO,Freitas-Astúa J,Kitajima EW,Pallás V,Sánchez-Navarro JÁ

    更新日期:2020-06-09 00:00:00

  • A New Pathway for Mannitol Metabolism in Yeasts Suggests a Link to the Evolution of Alcoholic Fermentation.

    abstract::The yeasts belonging to the Wickerhamiella and Starmerella genera (W/S clade) share a distinctive evolutionary history marked by loss and subsequent reinstatement of alcoholic fermentation mediated by horizontal gene transfer events. Species in this clade also share unusual features of metabolism, namely the preferenc...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02510

    authors: Gonçalves C,Ferreira C,Gonçalves LG,Turner DL,Leandro MJ,Salema-Oom M,Santos H,Gonçalves P

    更新日期:2019-11-01 00:00:00

  • Swine Manure Composting With Compound Microbial Inoculants: Removal of Antibiotic Resistance Genes and Their Associations With Microbial Community.

    abstract::In this study, compound microbial inoculants, including three Bacillus strains and one Yeast strain, were inoculated into swine manure composting to explore the effects on antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), microbial community structure, and pathogenic bacteria. The results indicate...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.592592

    authors: Li K,Cao R,Mo S,Yao R,Ren Z,Wu J

    更新日期:2020-11-03 00:00:00

  • Chromium Hyper-Tolerant Bacillus sp. MH778713 Assists Phytoremediation of Heavy Metals by Mesquite Trees (Prosopis laevigata).

    abstract::Heavy metal accumulation in mesquite trees (Prosopis laevigata) growing in aluminum, titanium, chromium and zirconium-polluted soils of a semi-arid region in Mexico was investigated using wavelength dispersive X-ray fluorescence analysis. The results showed that P. laevigata trees can hyper accumulate up to 4100 mg/kg...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01833

    authors: Ramírez V,Baez A,López P,Bustillos R,Villalobos MÁ,Carreño R,Contreras JL,Muñoz-Rojas J,Fuentes LE,Martínez J,Munive JA

    更新日期:2019-08-13 00:00:00

  • Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient.

    abstract::Dysbiosis of the gut microbiome, including elevated abundance of putative leading bacterial triggers such as E. coli in inflammatory bowel disease (IBD) patients, is of great interest. To date, most E. coli studies in IBD patients are focused on clinical isolates, overlooking their relative abundances and turnover ove...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02559

    authors: Fang X,Monk JM,Nurk S,Akseshina M,Zhu Q,Gemmell C,Gianetto-Hill C,Leung N,Szubin R,Sanders J,Beck PL,Li W,Sandborn WJ,Gray-Owen SD,Knight R,Allen-Vercoe E,Palsson BO,Smarr L

    更新日期:2018-10-30 00:00:00

  • Nutrient Stoichiometry Shapes Microbial Community Structure in an Evaporitic Shallow Pond.

    abstract::Nutrient availability and ratios can play an important role in shaping microbial communities of freshwater ecosystems. The Cuatro Ciénegas Basin (CCB) in Mexico is a desert oasis where, perhaps paradoxically, high microbial diversity coincides with extreme oligotrophy. To better understand the effects of nutrients on ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00949

    authors: Lee ZM,Poret-Peterson AT,Siefert JL,Kaul D,Moustafa A,Allen AE,Dupont CL,Eguiarte LE,Souza V,Elser JJ

    更新日期:2017-05-30 00:00:00

  • Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis.

    abstract::Multidrug-resistant tuberculosis (TB), defined as TB resistant to the two first-line drugs, isoniazid and rifampin, is a serious challenge to global TB eradication efforts. Although mutations in rpoA or rpoC have been proposed to compensate for this fitness cost due to rpoB mutation in rifampicin-resistant Mycobacteri...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02895

    authors: Xu Z,Zhou A,Wu J,Zhou A,Li J,Zhang S,Wu W,Karakousis PC,Yao YF

    更新日期:2018-11-30 00:00:00

  • First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis.

    abstract::Mycotic infections and their effect on the human condition have been widely overlooked and poorly surveilled by many health organizations even though mortality rates have increased in recent years. The increased usage of immunosuppressive and myeloablative therapies for the treatment of malignant as well as non-malign...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00272

    authors: Espinosa V,Rivera A

    更新日期:2016-03-03 00:00:00

  • Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1.

    abstract::Merkel cell polyomavirus (MCV) plays a causal role in ∼80% of Merkel cell carcinomas (MCC). MCV is clonally integrated into the MCC tumor genome, which results in persistent expression of large T (LT) and small T (sT) antigen oncoproteins encoded by the early locus. In MCV-positive MCC tumors, LT is truncated by prema...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00713

    authors: Velásquez C,Amako Y,Harold A,Toptan T,Chang Y,Shuda M

    更新日期:2018-04-11 00:00:00

  • Mathematical Modeling Approaches for Assessing the Joint Toxicity of Chemical Mixtures Based on Luminescent Bacteria: A Systematic Review.

    abstract::Developments in industrial applications inevitably accelerate the discharge of enormous substances into the environment, whereas multi-component mixtures commonly cause joint toxicity which is distinct from the simple sum of independent effect. Thus, ecotoxicological assessment, by luminescent bioassays has recently b...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2020.01651

    authors: Wang D,Wang S,Bai L,Nasir MS,Li S,Yan W

    更新日期:2020-07-31 00:00:00

  • Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model.

    abstract::Experimental manipulation of the intestinal microbiota influences health of the host and is a common application for synbiotics. Here Clostridium butyricum (C. butyricum, C.B) combined with corn bran (C.B + Bran) was taken as the synbiotics application in a waned pig model to investigate its regulation of intestinal h...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.03091

    authors: Zhang J,Sun J,Chen X,Nie C,Zhao J,Guan W,Lei L,He T,Chen Y,Johnston LJ,Zhao J,Ma X

    更新日期:2018-12-18 00:00:00

  • Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice.

    abstract::The incidence of non-alcoholic fatty liver disease (NAFLD) is rising annually, and emerging evidence suggests that the gut bacteria plays a causal role in NAFLD. Naringin, a natural flavanone enriched in citrus fruits, is reported to reduce hepatic lipid accumulation, but to date, no investigations have examined wheth...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.585066

    authors: Mu H,Zhou Q,Yang R,Zeng J,Li X,Zhang R,Tang W,Li H,Wang S,Shen T,Huang X,Dou L,Dong J

    更新日期:2020-11-13 00:00:00