Abstract：
BACKGROUND:Long-term use of hormones and immunosuppressive agents is necessary for treating polymyositis (PM)/dermatomyositis (DM) but may cause liver damage. At what point do the costs of treatment outweigh the benefits, and how will the breakeven point be determined? METHODS:Serum muscle enzyme changes in 93 PM/DM patients were analyzed over the course of hormone and immunosuppressive agent treatment. From the analysis, a forecasting method was developed to help anticipate possible drug-induced liver injury. RESULTS:Before treatment, CK levels were frequently elevated and showed correlation with ALT,AST,LDH and CK-MB levels (r=0.682, 0.766, 0.739 and 0.784, respectively). After treatment, all muscle enzyme levels were decreased except ALT (p>0.05). ALT level was positively correlated with CK level (r=0.681) in those patients whose CK level remained abnormal after treatment. Linear regression analysis yielded an equation(CK Level=12.66*ALT Level-136.23) that could predict potential liver damage. CONCLUSIONS:CK level was the most sensitive index of PM/DM and was highly correlated with other serum muscle enzyme levels. An equation capable of predicting potential liver damage according to the correlation of CK and ALT was produced.
journal_name
Ann Clin Lab Scijournal_title
Annals of clinical and laboratory scienceauthors
Shi Q,Niu J,Huang X,Pu Csubject
Has Abstractpub_date
2016-05-01 00:00:00pages
266-9issue
3eissn
0091-7370issn
1550-8080pii
46/3/266journal_volume
46pub_type
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journal_title：Annals of clinical and laboratory science
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