Bronchial hyperresponsiveness in asthmatic children. Correlation with macrophages and eosinophils in broncholavage fluid.

Abstract:

:Bronchial responsiveness assessed by histamine bronchial challenge testing in 22 children with chronic stable asthma was compared with the number of inflammatory cells per milliliter of broncholavage fluid obtained by fiberoptic bronchoscopy. Hyperresponsiveness was closely correlated with increased counts of eosinophils and macrophages and with the ratio of eosinophils to macrophages. There was no correlation of neutrophil or lymphocyte counts with bronchial hyperresponsiveness and none of the cell types was correlated with airway obstruction. Our findings support the hypotheses that macrophages may be important in the development of bronchial hyperresponsiveness in children with asthma and that they may modulate bronchial responsiveness both directly and by recruitment of eosinophils.

journal_name

Chest

journal_title

Chest

authors

Ferguson AC,Wong FW

doi

10.1378/chest.96.5.988

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

988-91

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)35113-3

journal_volume

96

pub_type

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