Abstract:
:Bronchial responsiveness assessed by histamine bronchial challenge testing in 22 children with chronic stable asthma was compared with the number of inflammatory cells per milliliter of broncholavage fluid obtained by fiberoptic bronchoscopy. Hyperresponsiveness was closely correlated with increased counts of eosinophils and macrophages and with the ratio of eosinophils to macrophages. There was no correlation of neutrophil or lymphocyte counts with bronchial hyperresponsiveness and none of the cell types was correlated with airway obstruction. Our findings support the hypotheses that macrophages may be important in the development of bronchial hyperresponsiveness in children with asthma and that they may modulate bronchial responsiveness both directly and by recruitment of eosinophils.
journal_name
Chestjournal_title
Chestauthors
Ferguson AC,Wong FWdoi
10.1378/chest.96.5.988subject
Has Abstractpub_date
1989-11-01 00:00:00pages
988-91issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(16)35113-3journal_volume
96pub_type
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