Risk of post-procedural bleeding in children on intravenous fish oil.

Abstract:

BACKGROUND:Intestinal failure-associated liver disease (IFALD) can be treated with parenteral fish oil (FO) monotherapy, but practitioners have raised concerns about a potential bleeding risk. This study aims to describe the incidence of clinically significant post-procedural bleeding (CSPPB) in children receiving FO monotherapy. METHODS:A retrospective chart review was performed on patients at our institution treated with intravenous FO for IFALD. CSPPB was defined as bleeding leading to re-operation, transfer to the intensive care unit, re-admission, or death, up to one month after any invasive procedure. RESULTS:From 244 patients reviewed, 183 underwent ≥1 invasive procedure(s) (n = 732). Five (0.68%, 95% CI 0.22-1.59%) procedures resulted in CSPPB. FO therapy was never interrupted. No deaths due to bleeding occurred. CONCLUSIONS:Findings suggest that FO therapy is safe, with a CSPPB risk no greater than that reported in the general population. O3FA should not be held in preparation for procedures or in the event of bleeding.

journal_name

Am J Surg

authors

Nandivada P,Anez-Bustillos L,O'Loughlin AA,Mitchell PD,Baker MA,Dao DT,Fell GL,Potemkin AK,Gura KM,Neufeld EJ,Puder M

doi

10.1016/j.amjsurg.2016.10.026

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

733-737

issue

4

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(16)30462-7

journal_volume

214

pub_type

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