Hyperkalemia in Heart Failure.

Abstract:

:Disorders of potassium homeostasis can potentiate the already elevated risk of arrhythmia in heart failure. Heart failure patients have a high prevalence of chronic kidney disease, which further heightens the risk of hyperkalemia, especially when renin-angiotensin-aldosterone system inhibitors are used. Acute treatment for hyperkalemia may not be tolerated in the long term. Recent data for patiromer and sodium zirconium cyclosilicate, used to treat and prevent high serum potassium levels on a more chronic basis, have sparked interest in the treatment of hyperkalemia, as well as the potential use of renin-angiotensin-aldosterone system inhibitors in patients who were previously unable to take these drugs or tolerated only low doses. This review discusses the epidemiology, pathophysiology, and outcomes of hyperkalemia in heart failure; provides an overview of traditional and novel ways to approach management of hyperkalemia; and discusses the need for further research to optimally treat heart failure.

journal_name

J Am Coll Cardiol

authors

Sarwar CM,Papadimitriou L,Pitt B,Piña I,Zannad F,Anker SD,Gheorghiade M,Butler J

doi

10.1016/j.jacc.2016.06.060

subject

Has Abstract

pub_date

2016-10-04 00:00:00

pages

1575-89

issue

14

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(16)34656-3

journal_volume

68

pub_type

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