Abstract：
OBJECTIVE:We provide a contemporary account of the key pathologic events pertaining to autism: the theory of oxidative stress and inflammatory causes, ideas of immune dysfunction, the probable biomarkers that can be used for diagnostics, and the use of pharmaceuticals and stem cells as possible candidates for the treatment of autism spectrum disorders (ASDs). METHODS:ASDs are a group of complex neurodevelopmental conditions characterized by abnormal patterns of attention and impaired social and communication skills. ASDs are also associated with numerous functional challenges and potentially harmful deficits, including restricted and repetitive behaviors, anxiety, irritability, seizures, and self-harm. RESULTS:Although the exact causes of ASDs are unknown, it is suggested that genetic, epigenetic, and environmental factors play critical roles. More recent findings support evidence for synaptic defects and impairments in brain information processing that are linked to social and perceptual skills. CONCLUSIONS:Owing to the clinical heterogeneity and lack of precise diagnostic tools, current therapeutic approaches aimed at managing ASD-associated conditions are not definitive.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Sivanesan S,Tan A,Jeyaraj R,Lam J,Gole M,Hardan A,Ashkan K,Rajadas Jdoi
10.1016/j.wneu.2016.09.100subject
Has Abstractpub_date
2017-02-01 00:00:00pages
659-672eissn
1878-8750issn
1878-8769pii
S1878-8750(16)30957-3journal_volume
98pub_type
杂志文章,评审abstract：OBJECTIVE:Spontaneous spinal subdural hematoma (SSSDH) is exceedingly rare, with significant morbidity in most patients. Acute neurologic deficit in the context of a SSSDH is considered a neurosurgical emergency. We performed a literature review and compared the results with our institutional experience to evaluate the...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.10.096
更新日期：2020-10-24 00:00:00
abstract：BACKGROUND:Since the 1980s, numerous operations have replaced posterior lumbar interbody fusion (PLIF) with human bone. These operations often involve expensive implants and complex procedures. Escalating expenditures in lumbar fusion surgery warrant re-evaluation of classical PLIF with allogeneic ilium and without ins...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.210
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Pituitary ependymoma is exceptionally rare. Its etiology, clinical presentation, radiologic feature, and treatment strategy are still a matter of debate. Only 7 human cases with limited data were reported in the English literature, and now we described another case of pituitary ependymoma. We also systematic...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.10.134
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:More than 120,000 anterior cervical discectomy and fusions (ACDFs) are performed annually. Pseudarthrosis is a potential delayed adverse event that affects up to 33% of patients. The degree to which this adverse event affects both patient quality-of-life (QOL) outcomes and health care costs is poorly underst...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.09.104
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Awake craniotomy is a technique used to maximize resection of lesions in eloquent areas of the brain and preserve function. Although its use in high-income centers is well documented for tumors and vascular lesions, reports of its use in low-middle-income countries are limited. There are no published series ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.10.070
更新日期：2021-01-01 00:00:00
abstract：:Labrune syndrome is a neurologic disorder that manifests as a progressive cerebral degeneration characterized by a radiologic triad of cerebral white matter disease (leukoencephalopathy), intracranial calcification, and cysts. The associated novel genetic mutation in SNORD118 has been recently identified. However, its...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.008
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Spinal adhesive arachnoiditis (SAA) is an inflammatory process of the meninges. Cystic changes and cicatrization may lead to neurologic deficits and immobilization. Therapy is difficult and often unsatisfactory. We describe 8 cases of extensive SAA after extradural spinal infection. METHODS:A total of 238 p...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.219
更新日期：2018-08-01 00:00:00
abstract：:Acute lymphoblastic lymphoma is a malignant hematologic disease in childhood but rarely initially involves epidural compartment in adults. A 20-year-old male presented with progressive osphyalgia with constipation. Contrasted magnetic resonance imaging showed multiple vertebrae of hypointense T1 signals and an intrasp...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.09.130
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To compare outcomes in the setting of spontaneous intracerebral hemorrhage (ICH) in patients taking aspirin (acetylsalicylic acid [ASA]) versus patients taking clopidogrel before hospitalization. METHODS:Patients admitted to the neurosurgical service with a spontaneous ICH while taking an antiplatelet agent ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.02.010
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Rosai-Dorfman disease (RDD) is a rare, benign histiocytosis disorder with only approximately 100 reported central nervous system cases in the literature. Even less common is skull base involvement of RDD, with about 41 reported cases. Radiographically, RDD can appear similar to a meningioma; the true diagnos...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2019.12.032
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:Despite the increasing awareness of scientific fraud, no attempt has been made to assess its prevalence in neurosurgery. The aim of our review was to assess the chronologic trend, reasons, research type/design, and country of origin of retracted neurosurgical publications. METHODS:Three independent reviewer...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.04.014
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:Flow diversion has emerged as a promising strategy for management of intracranial aneurysms. The purpose of this study was to determine whether treatment of large and giant aneurysms with the pipeline embolization device (PED) is more economical than traditional embolization strategies. METHODS:We identified...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2013.02.089
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Limited historical data suggest that concomitant placement of both a ventriculoperitoneal (VP) shunt and percutaneous endoscopic gastrostomy (PEG) tube is associated with an increased risk of complications, including VP shunt infections. Here we compare the outcomes and cost difference between 2 groups of pa...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.024
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Pineoblastoma is a rare malignant tumor of the pineal gland, which is more common in children. METHODS:We retrospectively reviewed 18 cases of pineoblastoma in children (10 girls), including general, clinical, and therapeutic information, and factors affecting prognosis. RESULTS:The median age of the child...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.135
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Neuronavigation has become a common means of placing pedicle screws in vertebral arthrodesis, because it reduces the incidence of complications related to poor screw positioning. OBJECTIVE:The To evaluate the accuracy of pedicle screw placement during lumbar arthrodesis performed with the new ROSA Spine rob...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.118
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Recent genetic analysis of primary central nervous system lymphoma (PCNSL) showed that the MyD88 L265P mutation, which is related to NF-κB signaling, was a genetic hallmark for PCNSL; thus it could serve as a genetic marker for diagnosis and a potential target for molecular therapy. However, the role of the ...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2017.12.028
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:This study sought to determine whether implantation of a newly designed nonfusion intracorporeal enhancement (NICE) system is an effective and safe way to treat osteoporotic vertebral compression fracture (OVCF). METHODS:Thirteen patients with OVCF (10 women, 3 men; mean age 69 years, T11-L4) were included. ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.039
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Spinal acupuncture is a relatively safe and common analgesic treatment, but it may be complicated by serious adverse effects, such as direct spinal cord and nerve root injury, subdural empyema, and epidural abscesses. In this report we compare our case of an extremely uncommon spinal epidural hematoma, which...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.03.125
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Primary hypothyroidism can cause both hyperprolactinemia and pituitary hyperplasia. The degree of hyperprolactinemia is generally modest, and rarely do prolactin concentrations exceed 100 ng/mL (4.34 nmol/L). This combination of hyperprolactinemia and pituitary gland enlargement might raise suspicion for a p...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.103
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Consistent data on head injury is lacking especially in the low- and middle-income countries. Our study tries to characterize patients with head injury at the emergency department of one of the few tertiary public hospitals giving neurosurgical care in the country. METHODS:A retrospective cross-sectional st...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.044
更新日期：2019-07-01 00:00:00
abstract：:Hydatid cyst is an infectious disease caused by Echinococcus granulosus, primarily involving the liver and lungs. The orbit is an extremely rare site for involvement with hydatid cyst. We present a 36-year-old man with unilateral visual loss, proptosis, and papilledema caused by an orbital hydatid cyst. ...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.03.030
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:Learning complex neuroanatomy is an arduous yet important task for every neurosurgical trainee. As technology has advanced, various modalities have been created to aid our understanding of anatomy. This study sought to assess the educational value of a virtual, 3-dimensional (3D) temporal bone model. METHODS...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2018.11.074
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Infection and skin fistula are well-known complications after cranioplasty leading to reconstruction exposure and usually requiring new surgical procedure with poor condition for cutaneous closure. We describe 2 cases using muscle forehead flap (MFF) to treat skin fistula and cranioplasty exposure. CASE DES...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.10.184
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:To evaluate effects of holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation on postoperative low back pain and improving functional status in patients with lumbar disc herniation undergoing transforaminal endoscopic lumbar discectomy (TELD). METHODS:The study enrolled 220 patients with lumbar disc herniat...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.265
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The transcanal transpromontorial approach has been introduced to remove vestibular schwannomas. As with other techniques, preservation of the facial nerve (FN) is challenging. This pilot study described FN outcomes of patients preoperatively and postoperatively assessed with electromyography (EMG) and blink ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.10.139
更新日期：2020-11-12 00:00:00
abstract：OBJECTIVE:To use three-dimensional (3D) printed craniocerebral models to guide neurosurgery and design the best operative route preoperatively. METHODS:Computed tomography, magnetic resonance imaging, computed tomography angiography, and functional magnetic resonance images of the patients were collected as needed, re...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.069
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:To correlate the presence of objectively measured wall enhancement on high-resolution vessel wall imaging (HR-VWI) with the clinical predictive scales PHASES, ELAPSS, and UIATS. METHODS:Patients with unruptured intracranial aneurysm (UIAs) prospectively underwent HR-VWI on a 3-T magnetic resonance imaging sc...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.12.123
更新日期：2020-12-31 00:00:00
abstract：BACKGROUND:Lumbar puncture is a common procedure that can be safely performed in most patients. Certain populations may have increased risk for complications following lumbar puncture, but the significance of basilar invagination is often underappreciated. CASE DESCRIPTION:A 45-year-old woman with basilar invagination...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.02.040
更新日期：2020-05-01 00:00:00
abstract：:Extent of resection and tumor grade are considered the most important predictors of progression-free survival (PFS) in meningiomas. However, adjuvant therapy for atypical meningiomas remains controversial, with variable PFS rates of up to 40%. The current mitotic index (MI) range for atypical meningiomas is broad, com...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.06.189
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the clinical outcomes of diagnostic transforaminal epidural injection (DTEI) in selective percutaneous endoscopic lumbar discectomy for multilevel disc herniation with monoradicular symptom. METHODS:A prospective randomized clinical study was performed from November 2013...
journal_title：World neurosurgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.wneu.2019.02.102
更新日期：2019-06-01 00:00:00
