Abstract:
:The maximal procedure is a restricted randomization method that maximizes the number of feasible allocation sequences under the constraints of the maximum tolerated imbalance and the allocation sequence length. It assigns an equal probability to all feasible sequences. However, its implementation is not easy due to the lack of the Markovian property of the conditional allocation probabilities. In this paper, we propose the asymptotic maximal procedure, which replaces the sequence-length-dependent conditional allocation probabilities with their asymptotic values. The new randomization procedure is compared with the original maximal procedure and few other randomization procedures with the maximum tolerated imbalance via simulations and is found to be a practical choice for future clinical trials.
journal_name
Stat Methods Med Resjournal_title
Statistical methods in medical researchauthors
Zhao W,Berger VW,Yu Zdoi
10.1177/0962280216677107subject
Has Abstractpub_date
2018-07-01 00:00:00pages
2142-2153issue
7eissn
0962-2802issn
1477-0334pii
0962280216677107journal_volume
27pub_type
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