Abstract:
INTRODUCTION:Partial or complete obstruction of the urinary tract is a common and challenging urological condition that may occur in patients of any age. Serum creatinine is the most commonly used method to evaluate global renal function, although it has low sensitivity for early changes in the glomerular filtration rate or unilateral renal pathology. Hence, finding another measurable parameter that reflects the adaptation of the renal physiology to these circumstances is important. Several recent studies have assessed the use of new biomarkers of acute kidney injury (AKI), but the information among patients with stone disease and those with obstructive uropathy is limited. MATERIAL AND METHODS:A prospective cohort study was conducted to determine the urinary levels of kidney injury molecule-1 (KIM-1), Total and Monomeric neutrophil gelatinase-associated lipocalin (NGAL) in patients with hydronephrosis secondary to renal stone disease, congenital ureteropelvic junction obstruction or ureteral stricture. Comparison between patients with hydronephrosis and no hydronephrosis was carried out along with correlation analysis to detect factors associated with biomarker expression. RESULTS:Urinary levels of KIM-1 significantly decreased after hydronephrosis treatment in patients with unilateral obstruction (1.19 ng/mL vs 0.76 ng/mL creatinine, p = 0.002), additionally KIM-1 was significantly higher in patients with hydronephrosis compared to stone disease patients without radiological evidence of obstruction (1.19 vs 0.64, p = 0.006). Total and Monomeric NGAL showed a moderate correlation with the presence of leukocyturia. We found that a KIM-1 value of 0.735 ng/mg creatinine had a sensitivity of 75% and specificity of 67% to predict the presence of hydronephrosis in preoperative studies (95% CI 0.58-0.87, p = 0.006). CONCLUSION:Our results show that KIM-1 is a promising biomarker of subclinical AKI associated with hydronephrosis in urological patients. NGAL values were influenced by the presence of leukocyturia, limiting its usefulness in this population.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Olvera-Posada D,Dayarathna T,Dion M,Alenezi H,Sener A,Denstedt JD,Pautler SE,Razvi Hdoi
10.1089/end.2016.0215subject
Has Abstractpub_date
2017-02-01 00:00:00pages
111-118issue
2eissn
0892-7790issn
1557-900Xjournal_volume
31pub_type
杂志文章abstract:PURPOSE:To evaluate the efficacy of transvesical obturator nerve block (ONB) in the prevention of obturator nerve reflex and leg jerking during transurethral resection of bladder tumors (TURBT). PATIENTS AND METHODS:A total of 60 patients were studied, in whom the transurethral resection of tumors on the posterolatera...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
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更新日期:2010-10-01 00:00:00
abstract:INTRODUCTION:Clinical studies have shown beneficial role of oral alpha-blockers for ureteral stent-related morbidity. However, the in vivo effects of oral alpha-blockers on a stented ureter are unclear. We evaluated the effects of alpha-blockade on ureteral dynamics in a stented porcine ureter. METHODS:Twenty-seven fe...
journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of endourology
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doi:10.1089/end.2006.20.248
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journal_title:Journal of endourology
pub_type: 杂志文章,多中心研究
doi:10.1089/end.2015.0109
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/end.2015.0561
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1995.9.483
更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2014.0810
更新日期:2015-08-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2006.0462
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several experienced practitioners of open surgery with limited or no laparoscopic background have adopted robot-assisted laparoscopic radical prostatectomy (RLRP) as an alternative to open radical prostatectomy (RRP), demonstrating outcomes comparable to those in large RRP and laparoscopic prosta...
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pub_type: 杂志文章
doi:10.1089/end.2006.0239
更新日期:2007-04-01 00:00:00
abstract:: Objectives: To describe our surgical technique of robotic ureteroileal reimplantation (RUIR) for ureteroileal anastomosis strictures with the use of near-infrared fluorescence imaging (NIFI) after transnephrostomic antegrade injection of indocyanine green in patients previ...
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pub_type: 杂志文章
doi:10.1089/end.2019.0376
更新日期:2019-10-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2012.0160
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Involvement of the bladder is seen in only 1% to 2% of patients with endometriosis. The diagnosis of vesical endometriosis is difficult to formulate, and it should be confirmed by cystoscopy with biopsy. However, this examination is often insufficient because of the submucosal-transmural location...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277902761403014
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To describe the surgical technique of robot-assisted sacral colpopexy (RASCP) and to assess its feasibility and safety in a high-volume laparoscopic center. PATIENT AND METHODS:12 women with symptomatic urogenital prolapse with or without concomitant urinary stress incontinence were treated with RASCP by one s...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
doi:10.1089/end.2010.0160
更新日期:2010-12-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1995.9.259
更新日期:1995-06-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.0469
更新日期:2007-12-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1998.12.265
更新日期:1998-06-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277903770802344
更新日期:2003-11-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/089277901300189394
更新日期:2001-05-01 00:00:00
abstract::Port placement for robot-assisted laparoscopic urologic surgery can be critical to effective completion of the minimally invasive procedure. An ideal port template would allow unhampered access to all critical structures during surgery, easy access for the bedside assistant, and minimization of arm collision with the ...
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pub_type: 杂志文章
doi:10.1089/end.2017.0578
更新日期:2017-12-01 00:00:00