Inhibition of calcium oxalate urolithiasis in a rat model of lithogenesis using bisphosphonates.

Abstract:

:Bisphosphonates bind renal calculi and inhibit calcium oxalate crystal growth in vitro. We evaluated their ability to inhibit calcium oxalate urolithiasis in a lithogenic rat model. Male Sprague-Dawley rats (four groups, eight rats each) were fed 1.0% ethylene glycol in their drinking water for 6 weeks. All rats had implantation of a 50- to 60-mg zinc pellet in their urinary bladder at the beginning of the 6-week period. The control group received no treatment. The other three groups received six weekly intraperitoneal injections of one of three bisphosphonates: pamidronate (APD), clodronate (CLO), or methylene diphosphonate (MDP). At the end of 6 weeks, the zinc pellet was retrieved and weighed; the kidneys were sectioned and stained to evaluate inflammation, tubular dilation, and crystal deposition; and blood and urine samples were analyzed for calcium and creatinine. There were no detectable biochemical differences between the control and the treatment groups. Zinc pellets removed from control animals had a significantly greater increase in weight secondary to crystal deposition than those from the treatment groups (mean 28.4% for control v 18.9%, 15.3%, and 18.6%, respectively, for animals given APD, CLO, and MDP). The control animals also had significantly higher scores for inflammation, tubular dilation, and crystal deposition than animals treated with MDP and CLO. Older and newer-generation bisphosphonates have an inhibitory effect on calcium oxalate urolithiasis that is demonstrable at relatively infrequent dosing intervals in vivo. More frequent dosing or higher doses may allow greater inhibition of stone formation.

journal_name

J Endourol

journal_title

Journal of endourology

authors

Gupta M,Tuncay OL,Valderrama E,Smith AD

doi

10.1089/end.1997.11.1

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

1-4

issue

1

eissn

0892-7790

issn

1557-900X

journal_volume

11

pub_type

杂志文章
  • Retrograde Endourological Management of Upper Urinary Tract Abnormalities in Patients with Ileal Conduit Urinary Diversion: A Dual-Center Experience.

    abstract:INTRODUCTION:Patients with ileal conduit urinary diversions are at an increased risk of long-term upper urinary tract (UUT) complications, including anastomotic strictures, infections, and urolithiasis. The reconstructed urinary system poses challenges for endoscopic manipulation. We present and describe our dual-cente...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2017.0271

    authors: Olson L,Satherley H,Cleaveland P,Zelhof B,Mokete M,Neilson D,Srirangam S

    更新日期:2017-09-01 00:00:00

  • Use of the NMDA antagonist magnesium sulfate during monitored anesthesia care for shockwave lithotripsy.

    abstract:PURPOSE:To assess whether intravenous magnesium sulfate infusion affects analgesic requirements during monitored anesthesia care (MAC) for shockwave lithotripsy (SWL). PATIENTS AND METHODS:Fifty patients in ASA class I or II undergoing SWL with MAC were randomized into two groups. Induction of MAC was produced by bolu...

    journal_title:Journal of endourology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/end.2006.0195

    authors: Kaymak C,Yilmaz E,Basar H,Ozcakir S,Apan A,Batislam E

    更新日期:2007-02-01 00:00:00

  • Classification and detection of errors in minimally invasive surgery.

    abstract:PURPOSE:To provide a comprehensive review of the classification of surgical errors as well as general measures to detect and prevent their occurrence. MATERIALS AND METHODS:Search in PubMed, Medline, and Cochrane library with combination of the key words: Endoscopy or surgical procedures, minimally invasive, and medic...

    journal_title:Journal of endourology

    pub_type: 杂志文章,meta分析

    doi:10.1089/end.2011.0068

    authors: Rassweiler MC,Mamoulakis C,Kenngott HG,Rassweiler J,de la Rosette J,Laguna MP

    更新日期:2011-11-01 00:00:00

  • Pathologic upstaging after laparoscopic radical nephrectomy.

    abstract:OBJECTIVE:Accurate tumor staging in renal cancer is critical for prognostic projections, follow-up schedules, clinical trials and potential systemic therapies. We studied patients undergoing laparoscopic radical nephrectomy (LRN) to determine the extent of upstaging on histopathology evaluation and correlated the clini...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2008.0399

    authors: Goel MC,Mohammadi Y,Sethi AS,Brown JA,Sundaram CP

    更新日期:2008-10-01 00:00:00

  • The clinical research office of the endourological society ureteroscopy global study: indications, complications, and outcomes in 11,885 patients.

    abstract:PURPOSE:To assess the current indications for ureteroscopy (URS) treatment, outcome in terms of stone-free rate, and intra- and postoperative complications using the modified Clavien grading system. PATIENTS AND METHODS:The Clinical Research Office of the Endourological Society collected prospective data as part of th...

    journal_title:Journal of endourology

    pub_type: 杂志文章,多中心研究

    doi:10.1089/end.2013.0436

    authors: de la Rosette J,Denstedt J,Geavlete P,Keeley F,Matsuda T,Pearle M,Preminger G,Traxer O,CROES URS Study Group.

    更新日期:2014-02-01 00:00:00

  • Does laparoscopy beget underuse of partial nephrectomy for T(1) renal masses? Competing treatment decision pathways may influence utilization.

    abstract:BACKGROUND AND PURPOSE:It has been suggested that renal laparoscopy has resulted in an underuse of partial nephrectomy (PN) for small renal masses in the U.S. In the absence of evidence-based medicine (EBM) guide-lines, multiple-perspective reasoning is required where complete v partial nephrectomy and the laparoscopic...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2007.0056

    authors: Perrotti M,Badger WJ,McLeod D,Prater S,Moran ME

    更新日期:2007-10-01 00:00:00

  • Case report: endoscopic unroofing of symptomatic peripelvic simple renal cyst.

    abstract::We report the ureteroscopic unroofing of a symptomatic peripelvic cyst with a holmium laser in a 37-year-old woman. At 1-year follow-up, the patient remains symptom free. Endoscopic management of peripelvic cysts is durable and can be performed safely. ...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2006.0469

    authors: O'Connor RC,Guralnick ML,Byrd GF,Murphy MJ,Sulman A

    更新日期:2007-12-01 00:00:00

  • Is postoperative arteriovenous fistula still a concern after en bloc stapling of the renal hilum during laparoscopic nephrectomy?

    abstract:PURPOSE:To report our experience with en bloc stapling of the renal hilum during laparoscopic nephrectomy (LN) and nephroureterectomy and to compare it with separate stapling performed during the same period at the same institution. PATIENTS AND METHODS:We conducted a retrospective review of 125 laparoscopic nephrecto...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2008.0528

    authors: Schatloff O,Ramon J,Lindner U,Kitrey N,Dotan Z,Nahtomi-Shick O,Nadu A

    更新日期:2009-04-01 00:00:00

  • Hypothermic robotic radical prostatectomy: impact on continence.

    abstract:INTRODUCTION:Radical prostatectomy undoubtedly causes inflammatory damage to surrounding neuromuscular tissues (i.e., bladder, urethra, and nerves) that may contribute to urinary incontinence. We report the use of local hypothermia during robot-assisted laparoscopic prostatectomy to attenuate this injury. METHODS:Regi...

    journal_title:Journal of endourology

    pub_type: 临床试验,杂志文章

    doi:10.1089/end.2009.0411

    authors: Finley DS,Osann K,Chang A,Santos R,Skarecky D,Ahlering TE

    更新日期:2009-09-01 00:00:00

  • Use of neurosurgical patties for dissection in laparoscopic procedures of the urinary tract.

    abstract::Minimal bleeding during endoscopic surgery of the urinary tract may prevent optimum vision. We used neurosurgical patties for dissection during our laparoscopic procedures in the pediatric population and aimed to describe this technique as an alternative to standard ways of dissection during laparoscopic procedures. W...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2010.0435

    authors: Burgu B,Aydogdu O,Wilcox D

    更新日期:2011-05-01 00:00:00

  • Urolithiasis as a hazard of sulfonamide therapy.

    abstract::We identified 40 patients (25 men and 15 women) who developed calculi composed totally or partially of sulfonamides (acetylsulfamethoxazole, sulfadiazine, and acetylsulfisoxazole) between 1980 and 1987. The incidence of sulfonamide stones is less than 1% of stones. Patient characteristics were determined from question...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.1994.8.401

    authors: Albala DM,Prien EL Jr,Galal HA

    更新日期:1994-12-01 00:00:00

  • Morphine-induced macrophage apoptosis modulates migration of macrophages: use of in vitro model of urinary tract infection.

    abstract:BACKGROUND:Morphine has been reported to alter immune function. Morphine-induced macrophage apoptosis has been shown to contribute to altered immune status in an opiate milieu. We studied the effect of morphine-induced macrophage apoptosis on the migration of macrophages. Because urinary tract infection (UTI) is one of...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/089277902320913314

    authors: Malik AA,Radhakrishnan N,Reddy K,Smith AD,Singhal PC

    更新日期:2002-10-01 00:00:00

  • Endoscopic cystocele surgery: lateral repair with combined suture/mesh technique.

    abstract::The lateral repair is an accepted method for the reconstitution of paravaginal defects. Several open or vaginal approaches have been described, but there is still a deficit of reproducible laparoscopic approaches. Thus, only a few clinics perform the laparoscopic approach although it offers several advantages compared...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2010.0096

    authors: Banerjee C,Noé KG

    更新日期:2010-10-01 00:00:00

  • Tubeless percutaneous nephrolithotomy: safe even in supracostal access.

    abstract:PURPOSE:This study was designed to determine the outcome and safety of tubeless percutaneous nephrolithotomy (PCNL) in the treatment of renal calculi. PATIENTS AND METHODS:Between November 2005 and March 2006, 48 patients were randomized to either an 18F Re-entry nephrostomy tube (group 1) or a 6F Double-J stent (grou...

    journal_title:Journal of endourology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/end.2006.0216

    authors: Sofikerim M,Demirci D,Huri E,Erşekerci E,Karacagil M

    更新日期:2007-09-01 00:00:00

  • Randomized controlled trial comparing retroperitoneal laparoscopic pyelolithotomy versus percutaneous nephrolithotomy for the treatment of large renal pelvic calculi: a pilot study.

    abstract:PURPOSE:To evaluate the efficacy and safety of retroperitoneal laparoscopic pyelolithotomy (RLP) versus percutaneous nephrolithotomy (PCNL) for large renal pelvic calculi using a randomized controlled trial. MATERIALS AND METHODS:Patients with large renal pelvic calculi were prospectively randomized using matched-pair...

    journal_title:Journal of endourology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/end.2014.0064

    authors: Li S,Liu TZ,Wang XH,Zeng XT,Zeng G,Yang ZH,Weng H,Meng Z,Huang JY

    更新日期:2014-08-01 00:00:00

  • Ureteroscopy with and without safety guide wire: should the safety wire still be mandatory?

    abstract:BACKGROUND AND PURPOSE:Although the evidence is sparse, most urologists advise the insertion of a safety guide wire (SGW) alongside the ureteroscope whenever performing ureteroscopy (URS). The aim of the study was to compare the results of ureteroscopic treatment for ureteral stones at the Oslo University Hospital (OUH...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2013.0248

    authors: Ulvik Ø,Rennesund K,Gjengstø P,Wentzel-Larsen T,Ulvik NM

    更新日期:2013-10-01 00:00:00

  • A Novel Flexible Ureteroscope with Omnidirectional Bending Tip Using Joystick-Type Control Unit (URF-Y0016): Initial Validation Study in Bench Models.

    abstract:: Purpose: The conventional flexible ureteroscope has limited access into the lower calix and often causes biomechanical stress to surgeons. Recently, a novel flexible ureteroscope with an omnidirectional bending tip with a joystick-type control unit (URF-Y0016; Olympus, Jap...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2019.0895

    authors: Tambo M,Inoue T,Miura H,Matsuzaki J,Nutahara K,Hamamoto S,Okada S,Fukuhara H,Fujisawa M,Matsuda T

    更新日期:2020-06-01 00:00:00

  • Improved functional deflection with a dual-deflection flexible ureteroscope.

    abstract:PURPOSE:To compare the maximal active deflection capabilities of a newly designed dual-deflection ureteroscope with those of a standard flexible ureteroscope. MATERIALS AND METHODS:The dual-deflection ureteroscope is similar in design to single-deflection ureteroscopes with the addition of a second, more proximal unid...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/089277904322959761

    authors: Shvarts O,Perry KT,Goff B,Schulam PG

    更新日期:2004-03-01 00:00:00

  • Impact of irrigation systems on stone migration.

    abstract:PURPOSE:To evaluate forces exerted on a stone with different ureteroscopic irrigation systems that could impact stone migration during ureteroscopy. MATERIALS AND METHODS:A 3-mm steel simulated stone was welded to a 3F stone basket. The basket wire was then backloaded into the working channel of a 4.5F Wolf semirigid ...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2007.0260

    authors: Hendlin K,Weiland D,Monga M

    更新日期:2008-03-01 00:00:00

  • Percutaneous cryoablation of renal masses >or=3 cm: efficacy and safety in treatment of 108 patients.

    abstract:PURPOSE:To evaluate our single institution experience with percutaneous cryoablation of renal masses >or=3 cm in diameter for complications and short-term outcomes. PATIENTS AND METHODS:Between March 2003 and February 2009, 108 patients with 110 renal masses >or=3 cm in diameter were treated with percutaneous cryoabla...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2009.0328

    authors: Schmit GD,Atwell TD,Callstrom MR,Farrell MA,Leibovich BC,Patterson DE,Chow GK,Blute ML,Charboneau JW

    更新日期:2010-08-01 00:00:00

  • Minimally invasive therapy for benign prostatic hyperplasia: practice patterns in Minnesota.

    abstract:BACKGROUND AND PURPOSE:Benign prostatic hyperplasia (BPH) affects more than 50% of men by the age of 60 and 90% by age 85. Many of these men are not candidates for surgical procedures such as transurethral resection of the prostate (TURP), stimulating the development of less-invasive forms of therapy. We studied the ut...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2005.19.159

    authors: Ercole B,Lee C,Best S,Fallon E,Skenazy J,Monga M

    更新日期:2005-03-01 00:00:00

  • Percutaneous nephrolithotomy requiring multiple tracts: comparison of morbidity with single-tract procedures.

    abstract:PURPOSE:To compare the morbidity of percutaneous nephrolithotomy (PCNL) requiring multiple percutaneous tracts with that of procedures requiring a single tract for calculus clearance. PATIENTS AND METHODS:Data from 20 patients undergoing PCNL through two or more percutaneous renal tracts over a 1-year period were comp...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2006.20.753

    authors: Hegarty NJ,Desai MM

    更新日期:2006-10-01 00:00:00

  • Laser lithotripsy and cyanide.

    abstract:BACKGROUND AND PURPOSE:Holmium:YAG lithotripsy of uric acid calculi produces cyanide. The laser and stone parameters required to produce cyanide are poorly defined. In this study, we tested the hypotheses that cyanide production: (1) varies with holmium:YAG power settings; (2) varies among holmium:YAG, pulsed-dye, and ...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2000.14.169

    authors: Corbin NS,Teichman JM,Nguyen T,Glickman RD,Rihbany L,Pearle MS,Bishoff JT

    更新日期:2000-03-01 00:00:00

  • Ureteroscopy for stone treatment using new 270 degrees semiflexible endoscope: in vitro, ex vivo, and clinical application.

    abstract:BACKGROUND AND PURPOSE:The use of flexible ureteroscopy for diagnosis and management of upper urinary tract diseases is limited both by loss of maximum active deflection through the inserted working probes and a high frequency of damage with consequent costs. A newly developed ureteroscope (Flex-X, Karl Storz) with a m...

    journal_title:Journal of endourology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/end.2006.0291

    authors: Wendt-Nordahl G,Trojan L,Alken P,Michel MS,Knoll T

    更新日期:2007-12-01 00:00:00

  • Camera-port site metastasis of a renal-cell carcinoma after robot-assisted partial nephrectomy.

    abstract:BACKGROUND AND PURPOSE:Port-site metastasis (PSM) is a rare complication of laparoscopic intervention in urologic malignancies. Of the greater than 50 reported cases of PSM in the urologic oncology literature, only 9 have occurred after surgery for renal-cell carcinoma (RCC). We report a 10th instance of RCC metastasis...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2012.0533

    authors: Song JB,Tanagho YS,Kim EH,Abbosh PH,Vemana G,Figenshau RS

    更新日期:2013-06-01 00:00:00

  • Can CT-Based Stone Impaction Markers Augment the Predictive Ability of Spontaneous Stone Passage?

    abstract:: Introduction: A number of clinical and radiological predictors of either stone impaction or ureteral stone passage (SP) have been proposed. We aimed at identifying the key predictors of successful SP by using readily available CT-based tools/measurements. ...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2020.0645

    authors: Kachroo N,Jain R,Maskal S,Alshara L,Armanyous S,Milk J,Kahn L,Monga M,Sivalingam S

    更新日期:2020-10-27 00:00:00

  • Complications of urologic laparoscopic surgery: a single institute experience of 1017 procedures.

    abstract:PURPOSE:We evaluated complications of urologic laparoscopic surgery at our institution. PATIENTS AND METHODS:From December 1991 to January 2009, 1017 urologic laparoscopic surgical procedures were performed in Kansai Medical University, including 277 radical prostatectomies, 13 donor nephrectomies, 74 partial nephrect...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2009.0322

    authors: Inoue T,Kinoshita H,Satou M,Oguchi N,Kawa G,Muguruma K,Murota T,Matsuda T

    更新日期:2010-02-01 00:00:00

  • Improving Drainage After Percutaneous Nephrolithotomy Based on Health-Related Quality of Life: A Prospective Randomized Study.

    abstract:PURPOSE:The impact of drainage type after percutaneous nephrolithotomy (PCNL) on the health-related quality of life (HRQoL) has been rarely studied. We conducted a prospective randomized study to evaluate the differences in HRQoL among patients who received different drainage types. METHODS:A total of 90 patients who ...

    journal_title:Journal of endourology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/end.2017.0444

    authors: Jiang H,Huang D,Yao S,Liu S

    更新日期:2017-11-01 00:00:00

  • Comparison of laparoscopic and open partial nephrectomy in clinical T1a renal tumors.

    abstract:PURPOSE:Partial nephrectomy has been established as a standard of care for T(1a) renal tumors. Laparoscopic partial nephrectomy (LPN) has been described as more difficult to perform than open partial nephrectomy (OPN). We compare our series of LPN and OPN. PATIENTS AND METHODS:From October 2002 to January 2006, 76 LPN...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2007.0300

    authors: Gong EM,Orvieto MA,Zorn KC,Lucioni A,Steinberg GD,Shalhav AL

    更新日期:2008-05-01 00:00:00

  • Robot-Assisted Radical Cystectomy for Bladder Cancer in Octogenarians.

    abstract:OBJECTIVE:To evaluate perioperative morbidity and mortality rate, a 3-year recurrence-free survival, and cancer-specific mortality rate in patients older than 80 years undergoing robot-assisted radical cystectomy (RARC). MATERIALS AND METHODS:We retrospectively collected data of 155 consecutive patients who received R...

    journal_title:Journal of endourology

    pub_type: 杂志文章

    doi:10.1089/end.2016.0050

    authors: De Groote R,Gandaglia G,Geurts N,Goossens M,Pauwels E,D'Hondt F,Gratzke C,Fossati N,De Naeyer G,Schatteman P,Carpentier P,Novara G,Mottrie A

    更新日期:2016-07-01 00:00:00