Abstract:
:Bisphosphonates bind renal calculi and inhibit calcium oxalate crystal growth in vitro. We evaluated their ability to inhibit calcium oxalate urolithiasis in a lithogenic rat model. Male Sprague-Dawley rats (four groups, eight rats each) were fed 1.0% ethylene glycol in their drinking water for 6 weeks. All rats had implantation of a 50- to 60-mg zinc pellet in their urinary bladder at the beginning of the 6-week period. The control group received no treatment. The other three groups received six weekly intraperitoneal injections of one of three bisphosphonates: pamidronate (APD), clodronate (CLO), or methylene diphosphonate (MDP). At the end of 6 weeks, the zinc pellet was retrieved and weighed; the kidneys were sectioned and stained to evaluate inflammation, tubular dilation, and crystal deposition; and blood and urine samples were analyzed for calcium and creatinine. There were no detectable biochemical differences between the control and the treatment groups. Zinc pellets removed from control animals had a significantly greater increase in weight secondary to crystal deposition than those from the treatment groups (mean 28.4% for control v 18.9%, 15.3%, and 18.6%, respectively, for animals given APD, CLO, and MDP). The control animals also had significantly higher scores for inflammation, tubular dilation, and crystal deposition than animals treated with MDP and CLO. Older and newer-generation bisphosphonates have an inhibitory effect on calcium oxalate urolithiasis that is demonstrable at relatively infrequent dosing intervals in vivo. More frequent dosing or higher doses may allow greater inhibition of stone formation.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Gupta M,Tuncay OL,Valderrama E,Smith ADdoi
10.1089/end.1997.11.1subject
Has Abstractpub_date
1997-02-01 00:00:00pages
1-4issue
1eissn
0892-7790issn
1557-900Xjournal_volume
11pub_type
杂志文章abstract:INTRODUCTION:Patients with ileal conduit urinary diversions are at an increased risk of long-term upper urinary tract (UUT) complications, including anastomotic strictures, infections, and urolithiasis. The reconstructed urinary system poses challenges for endoscopic manipulation. We present and describe our dual-cente...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2017.0271
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To assess whether intravenous magnesium sulfate infusion affects analgesic requirements during monitored anesthesia care (MAC) for shockwave lithotripsy (SWL). PATIENTS AND METHODS:Fifty patients in ASA class I or II undergoing SWL with MAC were randomized into two groups. Induction of MAC was produced by bolu...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2006.0195
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:To provide a comprehensive review of the classification of surgical errors as well as general measures to detect and prevent their occurrence. MATERIALS AND METHODS:Search in PubMed, Medline, and Cochrane library with combination of the key words: Endoscopy or surgical procedures, minimally invasive, and medic...
journal_title:Journal of endourology
pub_type: 杂志文章,meta分析
doi:10.1089/end.2011.0068
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Accurate tumor staging in renal cancer is critical for prognostic projections, follow-up schedules, clinical trials and potential systemic therapies. We studied patients undergoing laparoscopic radical nephrectomy (LRN) to determine the extent of upstaging on histopathology evaluation and correlated the clini...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0399
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To assess the current indications for ureteroscopy (URS) treatment, outcome in terms of stone-free rate, and intra- and postoperative complications using the modified Clavien grading system. PATIENTS AND METHODS:The Clinical Research Office of the Endourological Society collected prospective data as part of th...
journal_title:Journal of endourology
pub_type: 杂志文章,多中心研究
doi:10.1089/end.2013.0436
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It has been suggested that renal laparoscopy has resulted in an underuse of partial nephrectomy (PN) for small renal masses in the U.S. In the absence of evidence-based medicine (EBM) guide-lines, multiple-perspective reasoning is required where complete v partial nephrectomy and the laparoscopic...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2007.0056
更新日期:2007-10-01 00:00:00
abstract::We report the ureteroscopic unroofing of a symptomatic peripelvic cyst with a holmium laser in a 37-year-old woman. At 1-year follow-up, the patient remains symptom free. Endoscopic management of peripelvic cysts is durable and can be performed safely. ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.0469
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:To report our experience with en bloc stapling of the renal hilum during laparoscopic nephrectomy (LN) and nephroureterectomy and to compare it with separate stapling performed during the same period at the same institution. PATIENTS AND METHODS:We conducted a retrospective review of 125 laparoscopic nephrecto...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0528
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:Radical prostatectomy undoubtedly causes inflammatory damage to surrounding neuromuscular tissues (i.e., bladder, urethra, and nerves) that may contribute to urinary incontinence. We report the use of local hypothermia during robot-assisted laparoscopic prostatectomy to attenuate this injury. METHODS:Regi...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
doi:10.1089/end.2009.0411
更新日期:2009-09-01 00:00:00
abstract::Minimal bleeding during endoscopic surgery of the urinary tract may prevent optimum vision. We used neurosurgical patties for dissection during our laparoscopic procedures in the pediatric population and aimed to describe this technique as an alternative to standard ways of dissection during laparoscopic procedures. W...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0435
更新日期:2011-05-01 00:00:00
abstract::We identified 40 patients (25 men and 15 women) who developed calculi composed totally or partially of sulfonamides (acetylsulfamethoxazole, sulfadiazine, and acetylsulfisoxazole) between 1980 and 1987. The incidence of sulfonamide stones is less than 1% of stones. Patient characteristics were determined from question...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1994.8.401
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Morphine has been reported to alter immune function. Morphine-induced macrophage apoptosis has been shown to contribute to altered immune status in an opiate milieu. We studied the effect of morphine-induced macrophage apoptosis on the migration of macrophages. Because urinary tract infection (UTI) is one of...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277902320913314
更新日期:2002-10-01 00:00:00
abstract::The lateral repair is an accepted method for the reconstitution of paravaginal defects. Several open or vaginal approaches have been described, but there is still a deficit of reproducible laparoscopic approaches. Thus, only a few clinics perform the laparoscopic approach although it offers several advantages compared...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0096
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:This study was designed to determine the outcome and safety of tubeless percutaneous nephrolithotomy (PCNL) in the treatment of renal calculi. PATIENTS AND METHODS:Between November 2005 and March 2006, 48 patients were randomized to either an 18F Re-entry nephrostomy tube (group 1) or a 6F Double-J stent (grou...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2006.0216
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of retroperitoneal laparoscopic pyelolithotomy (RLP) versus percutaneous nephrolithotomy (PCNL) for large renal pelvic calculi using a randomized controlled trial. MATERIALS AND METHODS:Patients with large renal pelvic calculi were prospectively randomized using matched-pair...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2014.0064
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the evidence is sparse, most urologists advise the insertion of a safety guide wire (SGW) alongside the ureteroscope whenever performing ureteroscopy (URS). The aim of the study was to compare the results of ureteroscopic treatment for ureteral stones at the Oslo University Hospital (OUH...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0248
更新日期:2013-10-01 00:00:00
abstract:: Purpose: The conventional flexible ureteroscope has limited access into the lower calix and often causes biomechanical stress to surgeons. Recently, a novel flexible ureteroscope with an omnidirectional bending tip with a joystick-type control unit (URF-Y0016; Olympus, Jap...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2019.0895
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To compare the maximal active deflection capabilities of a newly designed dual-deflection ureteroscope with those of a standard flexible ureteroscope. MATERIALS AND METHODS:The dual-deflection ureteroscope is similar in design to single-deflection ureteroscopes with the addition of a second, more proximal unid...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277904322959761
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:To evaluate forces exerted on a stone with different ureteroscopic irrigation systems that could impact stone migration during ureteroscopy. MATERIALS AND METHODS:A 3-mm steel simulated stone was welded to a 3F stone basket. The basket wire was then backloaded into the working channel of a 4.5F Wolf semirigid ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2007.0260
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To evaluate our single institution experience with percutaneous cryoablation of renal masses >or=3 cm in diameter for complications and short-term outcomes. PATIENTS AND METHODS:Between March 2003 and February 2009, 108 patients with 110 renal masses >or=3 cm in diameter were treated with percutaneous cryoabla...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2009.0328
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Benign prostatic hyperplasia (BPH) affects more than 50% of men by the age of 60 and 90% by age 85. Many of these men are not candidates for surgical procedures such as transurethral resection of the prostate (TURP), stimulating the development of less-invasive forms of therapy. We studied the ut...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2005.19.159
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:To compare the morbidity of percutaneous nephrolithotomy (PCNL) requiring multiple percutaneous tracts with that of procedures requiring a single tract for calculus clearance. PATIENTS AND METHODS:Data from 20 patients undergoing PCNL through two or more percutaneous renal tracts over a 1-year period were comp...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.20.753
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Holmium:YAG lithotripsy of uric acid calculi produces cyanide. The laser and stone parameters required to produce cyanide are poorly defined. In this study, we tested the hypotheses that cyanide production: (1) varies with holmium:YAG power settings; (2) varies among holmium:YAG, pulsed-dye, and ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2000.14.169
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of flexible ureteroscopy for diagnosis and management of upper urinary tract diseases is limited both by loss of maximum active deflection through the inserted working probes and a high frequency of damage with consequent costs. A newly developed ureteroscope (Flex-X, Karl Storz) with a m...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2006.0291
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Port-site metastasis (PSM) is a rare complication of laparoscopic intervention in urologic malignancies. Of the greater than 50 reported cases of PSM in the urologic oncology literature, only 9 have occurred after surgery for renal-cell carcinoma (RCC). We report a 10th instance of RCC metastasis...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2012.0533
更新日期:2013-06-01 00:00:00
abstract:: Introduction: A number of clinical and radiological predictors of either stone impaction or ureteral stone passage (SP) have been proposed. We aimed at identifying the key predictors of successful SP by using readily available CT-based tools/measurements. ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2020.0645
更新日期:2020-10-27 00:00:00
abstract:PURPOSE:We evaluated complications of urologic laparoscopic surgery at our institution. PATIENTS AND METHODS:From December 1991 to January 2009, 1017 urologic laparoscopic surgical procedures were performed in Kansai Medical University, including 277 radical prostatectomies, 13 donor nephrectomies, 74 partial nephrect...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2009.0322
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:The impact of drainage type after percutaneous nephrolithotomy (PCNL) on the health-related quality of life (HRQoL) has been rarely studied. We conducted a prospective randomized study to evaluate the differences in HRQoL among patients who received different drainage types. METHODS:A total of 90 patients who ...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2017.0444
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:Partial nephrectomy has been established as a standard of care for T(1a) renal tumors. Laparoscopic partial nephrectomy (LPN) has been described as more difficult to perform than open partial nephrectomy (OPN). We compare our series of LPN and OPN. PATIENTS AND METHODS:From October 2002 to January 2006, 76 LPN...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2007.0300
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To evaluate perioperative morbidity and mortality rate, a 3-year recurrence-free survival, and cancer-specific mortality rate in patients older than 80 years undergoing robot-assisted radical cystectomy (RARC). MATERIALS AND METHODS:We retrospectively collected data of 155 consecutive patients who received R...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2016.0050
更新日期:2016-07-01 00:00:00