Abstract:
BACKGROUND:Morphine has been reported to alter immune function. Morphine-induced macrophage apoptosis has been shown to contribute to altered immune status in an opiate milieu. We studied the effect of morphine-induced macrophage apoptosis on the migration of macrophages. Because urinary tract infection (UTI) is one of the commonest infections to evoke an inflammatory response; i.e., migration of neutrophils and monocytes to the site of infection, we used an in vitro model of UTI to test our hypothesis. MATERIALS AND METHODS:We carried out both in vivo and in vitro studies. Mice of the FVB/N strain were treated with morphine for short (three doses, 24 hours) and long (11 doses, 96 hours) durations, and their bone marrow cells were isolated. In addition, apoptotic macrophages were prepared by heat treatment. To simulate the in vitro model of UTI, E. coli-activated tubular cell (TC)-conditioned medium containing transforming growth factor-beta (TGF-beta) and macrophage-monocyte chemoattractant protein-1 (MCP-1) was used to test migration of macrophages across a filter in a modified Boyden chamber. In addition, migration of macrophages into the peritoneal cavity was evaluated in both control and morphine-treated states. The effect of morphine on apoptosis as well as migration was studied in murine macrophages and bone marrow cells. RESULTS:Morphine not only promoted apoptosis of bone marrow cells (20% apoptotic cells) but also inhibited their migration across the filter. Control cells showed minimal apoptosis but displayed greater migration. Similarly, heat-treated (apoptotic) cells showed minimal migration. In peritoneal macrophage studies, morphine treatment retarded migration. CONCLUSION:Morphine inhibits macrophage migration both in vivo and in vitro. This attenuated transmigration of macrophages seems to be secondary to the apoptotic effect of morphine.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Malik AA,Radhakrishnan N,Reddy K,Smith AD,Singhal PCdoi
10.1089/089277902320913314subject
Has Abstractpub_date
2002-10-01 00:00:00pages
605-10issue
8eissn
0892-7790issn
1557-900Xjournal_volume
16pub_type
杂志文章abstract::Obtaining a precise fascial closure of larger laparoscopic port sites presents an ongoing challenge for even the most experienced laparoscopic surgeons. To this end, we evaluated five new methods for closing laparoscopic port sites and compared these with the standard technique of a hand-sutured repair using a 0 absor...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1995.9.397
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:The purpose is to report our 10-year experience with surgical management of large or symptomatic adrenal myelolipoma. PATIENTS AND METHODS:Patients receiving surgical treatment for adrenal myelolipoma between December 2001 and September 2011 in our institution were retrospectively reviewed. Patients were div...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0283
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To compare the morbidity of percutaneous nephrolithotomy (PCNL) requiring multiple percutaneous tracts with that of procedures requiring a single tract for calculus clearance. PATIENTS AND METHODS:Data from 20 patients undergoing PCNL through two or more percutaneous renal tracts over a 1-year period were comp...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.20.753
更新日期:2006-10-01 00:00:00
abstract::Because of the high rate of ipsilateral multifocal disease and the low incidence of contralateral disease, upper tract transitional-cell carcinoma has historically been treated with radical nephroureterectomy. This operation has been performed laparoscopically in many medical centers, with various techniques. The diff...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2000.14.859
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Extrinsic ureteral compression challenges a ureteral stent's ability to facilitate urinary drainage and to protect the kidney. Our purpose was to evaluate the performance of new metallic coil-based ureteral stents in terms of tensile strength and radial compression force. MATERIALS AND METHODS:T...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2011.0332
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We present the role of the transportal technique of laparoscopy-assisted surgeries.This report highlights the advantages of transportal technique over pure laparoscopic surgeries and laparoscopy-assisted surgeries. PATIENTS AND METHODS:In the last 3 years, we have adopted this approach for six p...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0209
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Oxalobacter formigenes is an anaerobic commensal colonic bacterium capable of degrading oxalate through the enzyme oxalyl-CoA decarboxylase. It has been theorized that individuals who lack this bacterium have higher intestinal oxalate absorption, leading to a higher urinary oxalate concentration ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277903321618743
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:Percutaneous stone surgery can be challenging in spina bifida (SB) patients due to their body habitus and spinal cord anomalies. A safe surgical approach may necessitate acceptance of lower stone-free (SF) rates. We seek to determine if anatomic complexity, as measured by spinal cord curvature and torso length,...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2016.0769
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The treatment of cystine stones is a clinical problem. This in vitro study was performed to establish an experimental system that enables standardized and reproducible investigations on chemolysis of cystine stones to look for an improvement of dissolution strategies. MATERIALS AND METHODS:Artif...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2000.14.451
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Renal Fine Needle Aspiration Cytology (FNAC) has gained popularity due to increasing options in management of renal lesions such as energy ablation and active surveillance. The diagnostic yield of renal FNAC varies between 40-90%. We hypothesized that adequate and diagnostic FNA samples would be ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.9724
更新日期:2008-10-01 00:00:00
abstract::Two women with symptomatic stone-filled caliceal diverticula were treated by a retroperitoneoscopic approach. With a three-port technique, the diverticulum was marsupialized, the calculi removed, the cavity fulgurated, and perirenal fat inserted. The patients had no morbidity and remain stone and symptom free. They re...
journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/end.2004.18.672
更新日期:2004-09-01 00:00:00
abstract::Small renal lesions often confer relatively low oncologic risk and, as such, dictate for treatment strategies with low morbidity. Minimally invasive ablative techniques have been developed and can deliver good outcomes where used judiciously. The potential risks of treatment relate to the method of ablation, the route...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2009.0542
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Conical blunt trocar insertion may eliminate the need for fascial closure (FC) in transperitoneal laparoscopic renal surgery. This concept applies to 12-mm blunt trocar placement through muscular parts of the abdominal wall, relying on muscle splitting and eventual muscle retraction when the troc...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277902753483718
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Surgical outcomes depend on patient and disease-related factors, as well as the technical skill of the surgeon. Various distractions in the operating room (OR) environment have been shown to negatively impact a surgeon's performance. A survey was conducted with the objective to evaluate and chara...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2012.0704
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Criteria for determining the durability of the response to transrectal high-intensity focused ultrasound (HIFU) ablation of prostate cancer have been established by calculating progression-free probability. PATIENTS AND METHODS:A series of 82 patients (mean age 71 +/- 5.7 years) with biopsy-prov...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
doi:10.1089/end.2000.14.519
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:To present the combination of laparoscopy and nephroscopy for the treatment of stones in pelvic ectopic kidneys. PATIENTS AND METHODS:The series included seven male and four female patients (mean age 43 +/- 9 years). Laparoscopy-assisted percutaneous nephrolithotomy (PCNL) was performed for caliceal stones in ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2007.9930
更新日期:2007-10-01 00:00:00
abstract:INTRODUCTION:The use of a ureteral access sheath (UAS) may provide significant advantages, particularly, in the treatment of a large renal stone burden. However, in some patients, the passage of a UAS up the ureter is impossible. We prospectively evaluated the ability to insert a 14F UAS and analyzed the possible predi...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2014.0215
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:We investigated the surgical efficiency and cutoff criteria to determine whether retrograde intrarenal surgery (RIRS) or supine miniaturized percutaneous nephrolithotomy (MPCNL) is appropriate for managing renal stones with a mean size >10 mm. MATERIALS AND METHODS:Data of a single session RIRS or supine MPC...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2017.0244
更新日期:2017-10-01 00:00:00
abstract::Laparoscopic living-donor nephrectomy has decreased the disincentives to live renal donation with a risk of complications similar to that of open donor nephrectomy. We report a patient who developed chylous ascites after an otherwise-uneventful laparoscopic donor nephrectomy. On MEDLINE search, we could find only two ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2005.19.839
更新日期:2005-09-01 00:00:00
abstract:: Objectives: To describe our surgical technique of robotic ureteroileal reimplantation (RUIR) for ureteroileal anastomosis strictures with the use of near-infrared fluorescence imaging (NIFI) after transnephrostomic antegrade injection of indocyanine green in patients previ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2019.0376
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:To evaluate the ability of heparin coating to inhibit Double J stent encrustation and compare it with the classic polyurethane Double J stent. PATIENTS AND METHODS:The study involved five patients with bilateral obstructions, who required bilateral ureteral Double J stent placement. Every patient received a he...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
doi:10.1089/end.2007.0218
更新日期:2008-03-01 00:00:00
abstract::Vesicoureteral reflux (VUR) in the animal model for experimental purposes can be created either by open transvesical or endoscopic techniques. The concept of reflux creation is the same for both techniques: incision of the roof of the intramural portion of the ureter at the 12 o'clock position. The open method has the...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1998.12.41
更新日期:1998-02-01 00:00:00
abstract::Chronic prostatitis and prostatodynia are troublesome disorders that are not responsive to any kind of treatment. Patients with treatment-resistant chronic nonbacterial prostatitis (n = 61) or prostatodynia (n = 17) for longer than 3 years underwent a single 1-hour session of transurethral microwave thermotherapy (TUM...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1994.8.61
更新日期:1994-02-01 00:00:00
abstract:PURPOSE:To compare the incidence of urethral strictures after monopolar transurethral resection of the prostate (TURP) and bipolar transurethral resection in saline (TURIS) for symptomatic benign prostatic hyperplasia. PATIENTS AND METHODS:Between January 2005 and January 2009, 518 patients with symptomatic benign pro...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2009.0575
更新日期:2010-08-01 00:00:00
abstract::In this review, a simplified straightforward algorithmic approach to the metabolic evaluation and treatment of the at-risk or recurrent urolithiasis patient is provided. Eight diagnoses and eight therapies are provided, which cover over 95% of renal stone disease. ...
journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/end.2017.0541
更新日期:2018-05-01 00:00:00
abstract:: Purpose: The conventional flexible ureteroscope has limited access into the lower calix and often causes biomechanical stress to surgeons. Recently, a novel flexible ureteroscope with an omnidirectional bending tip with a joystick-type control unit (URF-Y0016; Olympus, Jap...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2019.0895
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ablation by cold (cryoablation) or radiofrequency energy (RFA), has been popularized for the treatment of small renal tumors. Regrettably, there currently is no reliable method of radiologically monitoring the propagation of RF lesions in real time. Ultrasonography enhanced by gas-filled microbub...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2005.19.579
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To assess if the presence of a lower pole stone (LPS) decreases the stone-free (SF) rate following retrograde intrarenal surgery (RIRS). The second purpose was to assess the result of RIRS for LPS and to identify predictors of SF status. PATIENTS AND METHODS:We retrospectively analyzed 205 procedures in 162 ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0515
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent preclinical data have indicated that erythropoietin (Epo) can protect organs from ischemic damage. We evaluated the ability of Epo to protect the kidney from the effects of ischemia. METHODS:Thirty dogs underwent a laparoscopic nephrectomy and were allowed to recover for 2 weeks. The dogs...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0183
更新日期:2009-03-01 00:00:00
abstract::To assess the durability of the results of transurethral microwave thermotherapy (TUMT) for symptomatic benign prostatic hyperplasia (BPH), we have reviewed publications describing trials with at least 3 years of follow-up. For men treated only by TUMT, improvement in symptoms and quality of life appears to be maintai...
journal_title:Journal of endourology
pub_type: 杂志文章,meta分析
doi:10.1089/end.2000.14.671
更新日期:2000-10-01 00:00:00