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Prognostic Factors for Long-Term Survival in Patients with Renal-Cell Carcinoma After Radiofrequency Ablation.

Abstract：

PURPOSE:To assess the long-term survival and prognostic factors in patients with renal-cell carcinoma (RCC) who were treated with radiofrequency ablation (RFA). PATIENTS AND METHODS:A retrospective review of the records of all patients who underwent RFA of biopsy-proven RCC from February 2006 to December 2010 was performed in our institution. Univariate and multivariate analyses were used to evaluate the prognostic factors for long-term survival after RFA. RESULTS:RFA was performed in 122 patients (102 men, 20 women) with preoperative imaging available. Mean patient age was 58.5 years (standard deviation [SD]: 14.5), and mean tumor size was 3.4 cm (SD: 1.1). Tumor stage was T1a 93 (76.2%) or T1b 29 (23.8%). The mean follow-up period for RFA was 64.9 months (±11.6) (range 9-83 mos). In total, 5-year cancer-specific survival, 5-year disease-free survival (DFS), 5-year recurrence-free survival (RFS), 5-year metastasis-free survival, and 5-year overall survival (OS) of this cohort was 98.3%, 90.8%, 94.2%, 99.2%, and 98.4%, respectively. In comparison with patients in >3 cm group, patients in ≤3 cm group had better 5-year DFS (P = 0.009), 5-year OS (P = 0.036) and 5-year RFS (P = 0.011). Age and tumor size affected survival rates significantly at univariate analysis (P = 0.031, P = 0.033). Only tumor size was shown to have independent prognostic value in multivariate analysis (P = 0.034). CONCLUSION:In appropriately selected patients, RFA is an effective treatment option that provides comparable long-term survival. With use of RFA, there is a high probability of long-term survival of patients with small tumor size.

journal_name

J Endourol

journal_title

Journal of endourology

authors

Zhang F,Chang X,Liu T,Wang W,Zhao X,Ji C,Yang R,Guo H

doi

10.1089/end.2015.0454

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

37-42

issue

1

eissn

0892-7790

issn

1557-900X

journal_volume

30

pub_type

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