Abstract:
BACKGROUND:To determine the cost and efficacy of admitting patients for intravenous dihydroergotamine treatment and to identify factors associated with a higher likelihood of response to treatment. METHODS:We performed a retrospective review of all pediatric hospitalizations from 2001 to 2010 for intravenous dihydroergotamine therapy for headache. Data were collected using the REDcap database and consisted of multiple variables, including preadmission demographics, headache duration, use of prophylactic medications, inpatient therapies including dihydroergotamine dosing, procedures, consultations, total hospital cost, and headache severity at discharge and at follow-up. RESULTS:Seventy-four percent of the 145 individuals who were hospitalized were female. Mean age was 14.9 years. Headache was described as chronic or daily in almost all patients and 28 (19%) had status migrainosus. Sixty-six percent had a first-degree relative with migraine. The average length of stay was 3.7 days, and the average cost was $7569 per hospitalization. Patients received an average of eight doses of dihydroergotamine. At the time of discharge, 63% of patients reported improvement. Follow-up information was available for 68% of the cohort at a median of 42 days after discharge, and 21 of 99 patients (21%) experienced sustained relief of headache. Response to dihydroergotamine was correlated with a lower rate of comorbid diagnoses, lumbar puncture, and outpatient neuroimaging. Response also correlated to less expensive hospitalizations with an average cost of $5379 per hospitalization versus $7105 per hospitalization without positive response. Response was also correlated with a patient receiving more doses of intravenous dihydroergotamine. CONCLUSIONS:Although intravenous dihydroergotamine is an effective abortive medication for intractable migraine, it may provide only short-term headache relief in many pediatric patients. Hospitalization is relatively costly with only modest long-term benefit, especially in patients with chronic migraine or chronic daily headache.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Nelson GR,Bale JF,Kerr LMdoi
10.1016/j.pediatrneurol.2016.09.009subject
Has Abstractpub_date
2017-01-01 00:00:00pages
76-81eissn
0887-8994issn
1873-5150pii
S0887-8994(16)30434-9journal_volume
66pub_type
杂志文章abstract::Balamuthia amebic encephalitis is rarely reported in infants. To the best of our knowledge, amebic encephalitis complicated by a mycotic aneurysm was only described once. We report on an 8-month-child with laboratory-confirmed Balamuthia mandrillaris meningoencephalitis, complicated by a mycotic aneurysm of the middle...
journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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abstract::Epidermal nevus syndrome is a neurocutaneous disorder characterized by the association of epidermal nevi with central nervous system or skeletal abnormalities. Central nervous system abnormalities include hemimegalencephaly, hydrocephalus, various migration disorders, intraspinal lipomas, and enlarged spinal roots. Ra...
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
doi:10.1016/0887-8994(86)90014-7
更新日期:1986-05-01 00:00:00
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journal_title:Pediatric neurology
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2018.04.006
更新日期:2018-09-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2011.12.009
更新日期:2012-03-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(99)00023-5
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journal_title:Pediatric neurology
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abstract::We describe a case of female Becker muscular dystrophy with 45,X/46,X,r(X), carrying an out-of-frame deletion in a nonhot-spot region of the DMD gene. Multiplex polymerase chain reaction did not detect the deletion, because the deleted exons 31-42 comprise a nonhot-spot region, and the product for exon 43 was detected...
journal_title:Pediatric neurology
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doi:10.1016/j.pediatrneurol.2008.05.002
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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更新日期:1998-05-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2010.03.003
更新日期:2010-07-01 00:00:00
abstract::A 6-year-old, previously healthy male presented with fever and lethargy. Tuberculous meningitis was suspected after cerebrospinal fluid examination. Antituberculous drugs were administered, and an initial computed tomographic scan of brain revealed mild ventriculomegaly only. Steroids were instituted on day 16 and gra...
journal_title:Pediatric neurology
pub_type: 杂志文章,评审
doi:10.1016/j.pediatrneurol.2004.05.008
更新日期:2004-11-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(91)90091-x
更新日期:1991-05-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(86)90019-6
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2005.01.008
更新日期:2005-07-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(00)00230-7
更新日期:2001-01-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(90)90120-p
更新日期:1990-07-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(92)90039-2
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