Abstract：
:The prevalence of obesity and type 2 diabetes mellitus epidemics presents a great health problem worldwide. Beside the changes in diet and decreased physical activity, there is growing interest in endocrine disrupting chemicals that may have effects on these conditions. Among them, the role of certain phthalates and bisphenol A is confirmed. We have summarized the existing literature on this issue including cross-sectional, follow up epidemiological studies and in vivo and in vitro studies. Most data support the effects of bisphenol A and some phthalates, such as di-2-ethyl-hexyl phthalate, diethyl phthalate, dibuthyl phthalate, dimethyl phthalate, dibenzyl phthalate, diisononyl phthalate and others on the development obesity and type 2 diabetes mellitus. These endocrine disrupting chemicals interfere with different cell signaling pathways involved in weight and glucose homeostasis. Since the data are rather inconsistent, there is a need for new, well-designed prospective studies.
journal_name
Endocrinejournal_title
Endocrineauthors
Stojanoska MM,Milosevic N,Milic N,Abenavoli Ldoi
10.1007/s12020-016-1158-4subject
Has Abstractpub_date
2017-03-01 00:00:00pages
666-681issue
3eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-016-1158-4journal_volume
55pub_type
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