Abstract:
STUDY OBJECTIVE:To assess the association between medroxyprogesterone acetate exposure and bone mineral density (BMD) loss and weight change in adolescents. DESIGN:Forty-eight-week prospective, randomized trial conducted May 2012-April 2014. SETTING:Recruitment occurred in the general community and outpatient clinics in central Ohio. PARTICIPANTS:Self-referred sample of 34 female adolescents aged 12-21 years initiating depot medroxyprogesterone acetate (DMPA). INTERVENTIONS:Randomization to 1 of 3 DMPA doses (150, 104, or 75 mg) given intramuscularly every 12 weeks for 48 weeks. MAIN OUTCOME MEASURES:Absolute and percent change in BMD from 0-48 weeks at the L1-L4 lumbar spine, total hip, and femoral neck; absolute and percent change in weight at 48 weeks. RESULTS:DMPA dose was associated with medroxyprogesterone acetate exposure as evidenced by a direct relationship (P < .001) between dose group and area under the concentration time curve. At 48 weeks, no significant BMD decreases were seen in the 75 mg dose group. The 104 and 150 mg dose groups experienced significant (P < .01) decreases in L1-L4 lumbar spine BMD (3.1% and 4.0%, respectively). The 150 mg group also had significant (P < .05) decreases in total hip (3.0%) and femoral neck (4.0%) BMD. No group differences in weight change were observed. No pregnancies occurred in any DMPA dose group. CONCLUSIONS:Our data provide evidence of a dose-response relationship between DMPA and BMD loss. Intramuscular DMPA doses less than 150 mg can decrease risk of BMD loss in adolescents. The risk/benefit ratio of lower-dose DMPA should be further investigated in larger and more diverse adolescent populations.
journal_name
J Pediatr Adolesc Gynecoljournal_title
Journal of pediatric and adolescent gynecologyauthors
Lange HL,Manos BE,Gothard MD,Rogers LK,Bonny AEdoi
10.1016/j.jpag.2016.10.011subject
Has Abstractpub_date
2017-04-01 00:00:00pages
169-175issue
2eissn
1083-3188issn
1873-4332pii
S1083-3188(16)30237-6journal_volume
30pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:The purpose of this paper is to further describe prepubertal distal longitudinal vaginal folds and its natural history. DESIGN:Biopsy of the folds and follow-up through puberty. RESULTS:Histology of the folds shows normal vaginal mucosa over loose fibrous connective tissue without a firm fibrous core. The f...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2007.10.001
更新日期:2008-12-01 00:00:00
abstract:STUDY OBJECTIVE:Cervical cancer morbidity and mortality are pressing public health issues that affect women in Haiti. To inform efforts to develop a human papillomavirus (HPV) vaccination program in Haiti, we sought to understand HPV awareness and willingness to get HPV vaccination in Haiti. DESIGN, SETTING, AND PARTI...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2016.07.003
更新日期:2017-02-01 00:00:00
abstract:STUDY OBJECTIVE:Evidence suggests that vaccine-type human papillomavirus (HPV) prevalence may decrease in unvaccinated women after HPV vaccine introduction, indicating herd protection. The aim of this study was to determine factors associated with vaccine-type HPV (i.e. absence of herd protection) after vaccine introdu...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2017.09.008
更新日期:2018-04-01 00:00:00
abstract:STUDY OBJECTIVE:On the basis of longitudinal data collected over 6 years, the changes in delinquent behavior and the related sociodemographic, personal, and family determinants were examined in this study. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A 6-year longitudinal research design was...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2015.10.009
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To review the etiologies, diagnosis, and treatment options of adolescent endometriosis. METHODS:Review of publications relating to adolescent endometriosis. RESULTS:Endometriosis occurs in adolescents as young as 8 years of age; furthermore, there have been documented cases of endometriosis occurring prior...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章,评审
doi:10.1016/s1083-3188(03)00066-4
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The science of medicine is a constantly evolving process that builds on the experiences and observations of the past. We hypothesized that the issues of pediatric and adolescent gynecology were also of concern to physicians practicing in the 19th century. We sought to determine the extent to which our forebe...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 历史文章,杂志文章
doi:10.1016/s1083-3188(97)70083-4
更新日期:1997-11-01 00:00:00
abstract:STUDY OBJECTIVE:To characterize menstrual health issues and their effect in young women with Angelman syndrome (AS). Our secondary objective was to compare them with young women with autism spectrum disorders (ASDs). DESIGN:Cross-sectional convenience sample survey. SETTING:An institutional review board-approved Web-...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2015.12.004
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Absence of the lower vagina occurs from abnormal development of the sinovaginal bulbs and vaginal plate. CASE:We present a case of an adolescent girl, with a history of VACTERL and VATER status post flap vaginoplasty at 8 m of age and correction of vaginal-urethral fistula, with primary amenorrhea and cycli...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2012.10.007
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Juvenile cystic adenomyomas (JCAs) are rare uterine lesions. Differential diagnosis might be difficult. We present the case of an adolescent who was diagnosed with JCA and was managed with laparoscopic excision. CASE:A 14-year-old patient with complaint of menarche with excruciating dysmenorrhea, was diagno...
journal_title:Journal of pediatric and adolescent gynecology
pub_type:
doi:10.1016/j.jpag.2020.08.010
更新日期:2020-12-01 00:00:00
abstract:STUDY OBJECTIVE:Recent data show US adolescents are engaging in sexual activity at earlier ages; however, little is known about young teens' sexual attitudes and behaviors. Examining teens' questions in sex education classes may provide insight into these attitudes and behaviors. DESIGN:Quasi cohort study SETTING:Par...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2008.03.005
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:The objective of the study was to identify the presence of hydrosalpinx in postmenarchal nonsexually active girls in a children's hospital and to review the available literature on hydrosalpinx in this population. CASES:In a tertiary care children's hospital, we performed a retrospective review of charts fr...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jpag.2015.06.009
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Sarcoma botryoides of the female genital tract is a rare malignancy. For many years, treatment consisted of radical procedures involving removal of the vagina, cervix, and uterus. Reconstructive surgery is essential for these patients, in order to achieve vaginal penetrative sexual intercourse. CASE:A 17-ye...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2013.12.004
更新日期:2014-08-01 00:00:00
abstract:STUDY OBJECTIVE:To identify clinical features associated with primary ovarian insufficiency (POI) and collect data on the evaluation and treatment received. DESIGN:Retrospective chart review. Data were abstracted on etiology of POI, history, laboratory evaluation, imaging results, return for clinical care, and treatme...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2017.07.005
更新日期:2018-02-01 00:00:00
abstract::A laparoscopic technique is reported as an operative approach for gonadectomy in a case of testicular feminization syndrome. A 17-year-old phenotypic female presented with primary amenorrhea and was evaluated through a diagnostic protocol that included clinical, cytogenetic, and hormonal examinations. The findings sup...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/s1083-3188(99)00032-7
更新日期:2000-02-01 00:00:00
abstract:STUDY OBJECTIVE:To document physical and symptomatic changes in adolescent females using depot medroxyprogesterone acetate (DMPA) for contraception. DESIGN:A 30-month prospective experimental study using a convenience sample of subjects. SETTING:A pediatric primary care clinic in Milwaukee, Wisconsin that serves an u...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/s1083-3188(97)70039-1
更新日期:1997-02-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the racial/ethnic differences in the correlates of spontaneous and medically-indicated late preterm birth (LPTB), defined as deliveries between 34 0/7 and 36 6/7 weeks gestation, among US adolescents. DESIGN:Population-based, retrospective cohort study. SETTING:Births in the United Stat...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2016.08.004
更新日期:2017-02-01 00:00:00
abstract:STUDY OBJECTIVE:To understand adolescent girls' use of "I don't know" within the context of discussing information related to sexual attitudes and behaviors. DESIGN:Qualitative analysis of seven focus groups with adolescent girls. SETTING:Urban primary care clinic. PARTICIPANTS:Adolescent girls (n = 23) with a mean ...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2006.05.001
更新日期:2006-08-01 00:00:00
abstract::Adolescents are at high risk of acquiring and becoming reinfected with sexually transmitted infections. Partner notification and treatment are essential to preventing the spread of sexually transmitted infections. Expedited partner therapy (EPT) is a method of partner treatment used by medical providers to treat patie...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jpag.2017.01.012
更新日期:2017-06-01 00:00:00
abstract:STUDY OBJECTIVE:To describe contraceptive use among female adolescents initiating outpatient treatment for opioid use disorder. DESIGN:Retrospective chart review. SETTING:Outpatient clinic providing medication-assisted treatment for substance use disorders to adolescents and young adults. PARTICIPANTS:Nonpregnant fe...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2017.11.002
更新日期:2018-04-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the efficacy of oral tranexamic acid (TA) with combined oral contraceptives (COC) in reducing menstrual blood loss (MBL) and improving quality of life in adolescent heavy menstrual bleeding (HMB). DESIGN, SETTING, AND PARTICIPANTS:A prospective randomized crossover trial with 17 postmenarcha...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpag.2014.12.012
更新日期:2015-08-01 00:00:00
abstract:STUDY OBJECTIVE:To describe a hybrid simulation model for pediatric and adolescent gynecology (PAG) examination teaching, to evaluate if it would be feasible to be conducted as a part of the PAG training, and to find out how it would be perceived by the trainees. DESIGN:The development process and a 2-day workshop is ...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2018.12.001
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To create a data management system that: (1) standardizes antecedent, program, and outcome variables relevant to the shared goals of adolescent-oriented maternity programs while allowing users to add variables pertaining to unique aspects of their work; (2) cues providers to physiologic and psychosocial charact...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2004.07.005
更新日期:2004-10-01 00:00:00
abstract:STUDY OBJECTIVE:To compare use of the weekly transdermal contraceptive patch (patch) with daily combined hormonal contraceptive pills (pills) in adolescents. DESIGN:Prospective longitudinal study of adolescents' self-selected (non-randomized) use of the patch or pills. SETTING:Urban, university hospital-affiliated, a...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2011.02.001
更新日期:2011-08-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the effect of providing standardized counseling to improve the rates of contraception initiation and utilization among detained young women. This was a quality improvement (QI) project conducted at a large urban juvenile short-term detention center. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2018.01.002
更新日期:2018-08-01 00:00:00
abstract:STUDY OBJECTIVE:To understand factors influencing use and nonuse of contraception in young, low-income Latina adolescents through focus group conversations. DESIGN:We conducted seven focus group discussions with Latino females in an outpatient clinic and community setting. Qualitative data analyses techniques were use...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2004.05.003
更新日期:2004-08-01 00:00:00
abstract:STUDY OBJECTIVE:To document an unusual presentation of a pure Sertoli Cell tumor. DESIGN:Case report. RESULTS:We present a 10-year-old female who presented with abdominal pain and diarrhea with no symptoms of puberty. Surgical exploration revealed a metastatic pure Sertoli Cell tumor, which was treated with resection...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2007.04.009
更新日期:2007-08-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the attitudes and practices of cystic fibrosis (CF) providers toward sexual and reproductive health (SRH) care in young women with CF. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS:Adult and pediatric US CF providers were sent an online survey exploring their attitudes toward SRH impo...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2017.01.009
更新日期:2017-10-01 00:00:00
abstract:STUDY OBJECTIVE:To determine pelvic inflammatory disease (PID) incidence and recurrence rates in an urban teen clinic. DESIGN/SETTING:A retrospective chart review of female patients seen as outpatients over an 18-month period at an urban teen clinic. 192 patients were diagnosed with PID, and the charts of these patien...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/j.jpag.2004.09.017
更新日期:2004-12-01 00:00:00
abstract:STUDY OBJECTIVE:This study was undertaken to assess the causes and treatments of menorrhagia in adolescents hospitalized for this menstrual disorder. DESIGN:A retrospective chart review was performed of all adolescents < or =20 years of age with menorrhagia admitted at the University of Michigan from 1979 to 1995. Inf...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章
doi:10.1016/s1083-3188(98)70101-9
更新日期:1998-02-01 00:00:00
abstract::Today's generation of adolescents and young adults have been labeled "digital natives" given that they have had access to digital technology since birth. In this review, we address 2 critical areas affecting adolescents' reproductive health and social media. First, we address the current state of the science across se...
journal_title:Journal of pediatric and adolescent gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jpag.2020.06.016
更新日期:2020-12-01 00:00:00