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Physical findings and symptoms of depot medroxyprogesterone acetate use in adolescent females.

Abstract：

STUDY OBJECTIVE:To document physical and symptomatic changes in adolescent females using depot medroxyprogesterone acetate (DMPA) for contraception. DESIGN:A 30-month prospective experimental study using a convenience sample of subjects. SETTING:A pediatric primary care clinic in Milwaukee, Wisconsin that serves an urban population of low socioeconomic status. PARTICIPANTS:A mostly African-American group of 53 patients (mean age 16.5 +/- 1.3 years). INTERVENTIONS:Subjects received 150 mg DMPA intramuscularly in either the deltoid or gluteus muscle. The first two DMPA injections were given 6-8 weeks apart in an effort to decrease menstrual irregularity. Subsequent injections were given every 3 months. A questionnaire was administered at each visit to document physical and symptomatic changes. MAIN OUTCOME MEASURES:Included weight change, frequency and amount of menstrual bleeding, and perceived side effects and satisfaction both documented with a 5-point Likert scale. RESULTS:At 5, 11, and 17 months of DMPA use, 75%, 40%, and 19% of subjects continued DMPA. The most commonly perceived side effects were weight gain (27%), headache (25%), irregular periods (24%), fatigue (23%), abdominal pain (18%), and decreased sexual desire (15%). Significant weight gain was noted with an average increase of 6.0 +/- 6.0 kg at 11 months of DMPA use and 9.0 +/- 5.4 kg at 17 months. No menstrual bleeding was experienced by 30%-40% of adolescents in any 3-month injection period, and those who bled averaged 8-13 days of bleeding between injections. No pregnancies occurred and 87% of patients were either satisfied or very satisfied with DMPA as a method of contraception. CONCLUSION:Despite the documented side effects, DMPA is an effective, acceptable contraceptive for some adolescent females who are at high risk for pregnancy.

journal_name

J Pediatr Adolesc Gynecol

journal_title

Journal of pediatric and adolescent gynecology

authors

Matson SC,Henderson KA,McGrath GJ

doi

10.1016/s1083-3188(97)70039-1

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

18-23

issue

eissn

1083-3188

issn

1873-4332

pii

S1083-3188(97)70039-1

journal_volume

pub_type

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Physical findings and symptoms of depot medroxyprogesterone acetate use in adolescent females.