当前位置： SCI文献检索 > Acta Biomaterialia期刊下所有文献 > Boronic acid-tethered amphiphilic hyaluronic acid derivative-based nanoassemblies for tumor targeting and penetration.

Boronic acid-tethered amphiphilic hyaluronic acid derivative-based nanoassemblies for tumor targeting and penetration.

Abstract：

:(3-Aminomethylphenyl)boronic acid (AMPB)-installed hyaluronic acid-ceramide (HACE)-based nanoparticles (NPs), including manassantin B (MB), were fabricated for tumor-targeted delivery. The amine group of AMPB was conjugated to the carboxylic acid group of hyaluronic acid (HA) via amide bond formation, and synthesis was confirmed by spectroscopic methods. HACE-AMPB/MB NPs with a 239-nm mean diameter, narrow size distribution, negative zeta potential, and >90% drug encapsulation efficiency were fabricated. Exposed AMPB in the outer surface of HACE-AMPB NPs (in the aqueous environment) may react with sialic acid of cancer cells. The improved cellular accumulation efficiency, in vitro antitumor efficacy, and tumor penetration efficiency of HACE-AMPB/MB NPs, compared with HACE/MB NPs, in MDA-MB-231 cells (CD44 receptor-positive human breast adenocarcinoma cells) may be based on the CD44 receptor-mediated endocytosis and phenylboronic acid-sialic acid interaction. Enhanced in vivo tumor targetability, infiltration efficiency, and antitumor efficacies of HACE-AMPB NPs, compared with HACE NPs, were observed in a MDA-MB-231 tumor-xenografted mouse model. In addition to passive tumor targeting (based on an enhanced permeability and retention effect) and active tumor targeting (interaction between HA and CD44 receptor), the phenylboronic acid-sialic acid interaction can play important roles in augmented tumor targeting and penetration of HACE-AMPB NPs. STATEMENT OF SIGNIFICANCE: (3-Aminomethylphenyl)boronic acid (AMPB)-tethered hyaluronic acid-ceramide (HACE)-based nanoparticles (NPs), including manassantin B (MB), were fabricated and their tumor targeting and penetration efficiencies were assessed in MDA-MB-231 (CD44 receptor-positive human adenocarcinoma) tumor models. MB, which exhibited antitumor efficacies via the inhibition of angiogenesis and hypoxia inducible factor (HIF)-1, was entrapped in HACE-AMPB NPs in this study. Phenylboronic acid located in the outer surface of HACE-AMPB/MB NPs (in the aqueous milieu) may react with the sialic acid over-expressed in cancer cells and intramolecular B‒O bond can be formed. This phenylboronic acid-sialic acid interaction may provide additional tumor targeting and penetration potentials together with an enhanced permeability and retention (EPR) effect (passive tumor targeting) and HA-CD44 receptor interaction (active tumor targeting). Developed HACE-AMPB NP may be one of promising nanocarriers for the imaging and therapy of CD44 receptor-expressed cancers.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Jeong JY,Hong EH,Lee SY,Lee JY,Song JH,Ko SH,Shim JS,Choe S,Kim DD,Ko HJ,Cho HJ

doi

10.1016/j.actbio.2017.02.030

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

414-426

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(17)30135-6

journal_volume

53

pub_type

杂志文章

相关文献

Acta Biomaterialia文献大全
  • Improved bone-forming functionality on diameter-controlled TiO(2) nanotube surface.

    abstract：:The titanium dioxide (TiO(2)) nanotube surface enables significantly accelerated osteoblast adhesion and exhibits strong bonding with bone. We prepared various sizes (30-100 nm diameter) of titanium dioxide (TiO(2)) nanotubes on titanium substrates by anodization and investigated the osteoblast cellular behavior in re...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.05.008

    authors： Brammer KS,Oh S,Cobb CJ,Bjursten LM,van der Heyde H,Jin S

    更新日期：2009-10-01 00:00:00

  • Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers.

    abstract：:As the potential range of stem cell applications in tissue engineering continues to grow, the appropriate scaffolding choice is necessary to create tightly defined artificial microenvironments for each target organ. These microenvironments determine stem cell fate via control over differentiation. In this study we exa...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2010.11.022

    authors： Nam J,Johnson J,Lannutti JJ,Agarwal S

    更新日期：2011-04-01 00:00:00

  • Biphasic silica/apatite co-mineralized collagen scaffolds stimulate osteogenesis and inhibit RANKL-mediated osteoclastogenesis.

    abstract：:The effects of a biphasic mineralized collagen scaffold (BCS) containing intrafibrillar silica and apatite on osteogenesis of mouse mesenchymal stem cells (mMSCs) and inhibition of receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclastogenesis were investigated in the present study. mMSCs were cult...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2015.03.012

    authors： Jiao K,Niu LN,Li QH,Chen FM,Zhao W,Li JJ,Chen JH,Cutler CW,Pashley DH,Tay FR

    更新日期：2015-06-01 00:00:00

  • The effect of autoclaving on the physical and biological properties of dicalcium phosphate dihydrate bioceramics: brushite vs. monetite.

    abstract：:Dicalcium phosphate dihydrate (brushite) is an osteoconductive biomaterial with great potential as a bioresorbable cement for bone regeneration. Preset brushite cement can be dehydrated into dicalcium phosphate anhydrous (monetite) bioceramics by autoclaving. This heat treatment results in changes in the physical char...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2012.04.025

    authors： Tamimi F,Le Nihouannen D,Eimar H,Sheikh Z,Komarova S,Barralet J

    更新日期：2012-08-01 00:00:00

  • Cryogel scaffolds for regionally constrained delivery of lysophosphatidylcholine to central nervous system slice cultures: A model of focal demyelination for multiple sclerosis research.

    abstract：:The pathology of multiple sclerosis (MS) is typified by focal demyelinated areas of the brain and spinal cord, which results in axonal degeneration and atrophy. Although the field has made much progress in developing immunomodulatory therapies to reduce the occurrence of these focal lesions, there is a conspicuous lac...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.08.030

    authors： Eigel D,Zoupi L,Sekizar S,Welzel PB,Werner C,Williams A,Newland B

    更新日期：2019-10-01 00:00:00

  • Staphylococcus epidermidis originating from titanium implants infects surrounding tissue and immune cells.

    abstract：:Infection is a major cause of failure of inserted or implanted biomedical devices (biomaterials). During surgery, bacteria may adhere to the implant, initiating biofilm formation. Bacteria are also observed in and recultured from the tissue surrounding implants, and may even reside inside host cells. Whether these bac...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2014.08.012

    authors： Riool M,de Boer L,Jaspers V,van der Loos CM,van Wamel WJB,Wu G,Kwakman PHS,Zaat SAJ

    更新日期：2014-12-01 00:00:00

  • Inhibition of LPS-induced proinflammatory responses of J774.2 macrophages by immobilized enzymatically tailored pectins.

    abstract：:The surface of an implant device can be modified by immobilizing biological molecules on it to improve its integration into the host tissue. We have previously demonstrated that enzymatically tailored plant pectins are promising nanocoatings for biomaterials. This study investigates whether a coating of modified hairy...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2009.03.031

    authors： Gallet M,Vayssade M,Morra M,Verhoef R,Perrone S,Cascardo G,Vigneron P,Schols HA,Nagel MD

    更新日期：2009-09-01 00:00:00

  • Substitutions of cerium, gallium and zinc in ordered mesoporous bioactive glasses.

    abstract：:Ordered mesoporous glasses based on the 80% SiO(2)-15% CaO-5% P(2)O(5) system including up to 3.5% Ce(2)O(3), 3.5% Ga(2)O(3) or 7.0% ZnO (in mol.%) were synthesized by the evaporation-induced self-assembly process using Pluronic® 123 as a surfactant. An ordered hexagonal mesophase was observed in both the unsubstitute...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2011.05.033

    authors： Salinas AJ,Shruti S,Malavasi G,Menabue L,Vallet-Regí M

    更新日期：2011-09-01 00:00:00

  • Anisotropy of nickel release and corrosion in austenitic stainless steels.

    abstract：:The study of 316L-type stainless steel reveals a significant anisotropy of nickel release that is dependent on the orientation of the test surface with respect to the casting and rolling direction. Cross-sectional specimens (transversal cuts with respect to the rolling direction) show a substantially higher sensitivit...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2007.10.008

    authors： Reclaru L,Lüthy H,Ziegenhagen R,Eschler PY,Blatter A

    更新日期：2008-05-01 00:00:00

  • Rate-dependency of the mechanical behaviour of semilunar heart valves under biaxial deformation.

    abstract：:This paper presents an experimental investigation and evidence of rate-dependency in the planar mechanical behaviour of semilunar heart valves. Samples of porcine aortic and pulmonary valves were subjected to biaxial deformations across 1000-fold stretch rate, ranging from λ̇=0.001 to 1 s-1. The experimental campaign ...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.02.008

    authors： Anssari-Benam A,Tseng YT,Holzapfel GA,Bucchi A

    更新日期：2019-04-01 00:00:00

  • Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation.

    abstract：:We investigated the in vivo therapeutic efficacy of an intra-articular controlled release system consisting of biodegradable poly(dl-lactic-co-glycolic acid) (PLGA) microparticles (MPs) encapsulating anti-inflammatory small interfering RNA (siRNA), together with branched poly(ethylenimine) (PEI) as a transfecting agen...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2012.06.031

    authors： Mountziaris PM,Tzouanas SN,Sing DC,Kramer PR,Kasper FK,Mikos AG

    更新日期：2012-10-01 00:00:00

  • Janus nanocarrier-based co-delivery of doxorubicin and berberine weakens chemotherapy-exacerbated hepatocellular carcinoma recurrence.

    abstract：:Despite the rapid progress which has been made in hepatocellular carcinoma (HCC) chemotherapeutics, recurrence of liver cancer still remains a barrier to achieve satisfying prognosis. Herein, we aimed to decipher the role of berberine (BER) in chemotherapy-exacerbated HCC repopulation via developing a nanocarrier co-d...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.09.034

    authors： Zhang F,Jia Y,Zheng X,Shao D,Zhao Y,Wang Z,Dawulieti J,Liu W,Sun M,Sun W,Pan Y,Cui L,Wang Y,He K,Zhang M,Li J,Dong WF,Chen L

    更新日期：2019-12-01 00:00:00

  • Tailored design of multifunctional and programmable pH-responsive self-assembling polypeptides as drug delivery nanocarrier for cancer therapy.

    abstract：:Breast cancer has become the second leading cause of cancer-related mortality in female wherein more than 90% of breast cancer-related death results from cancer metastasis to distant organs at advanced stage. The purpose of this study is to develop biodegradable nanoparticles composed of natural polypeptides and calci...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2017.06.008

    authors： Wang TW,Yeh CW,Kuan CH,Wang LW,Chen LH,Wu HC,Sun JS

    更新日期：2017-08-01 00:00:00

  • Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure.

    abstract：:Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for bone defects resulting from malignant bone tumors. The development of bioactive materials with magnetic and drug delivery properties may potentially meet this target. The aim of this study was to develop a multifunctional m...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2011.06.028

    authors： Wu C,Fan W,Zhu Y,Gelinsky M,Chang J,Cuniberti G,Albrecht V,Friis T,Xiao Y

    更新日期：2011-10-01 00:00:00

  • Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment.

    abstract：:The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loaded-antibiotic within this matrix would ...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2019.07.001

    authors： Martínez-Carmona M,Izquierdo-Barba I,Colilla M,Vallet-Regí M

    更新日期：2019-09-15 00:00:00

  • Friction and wear behavior of ultra-high molecular weight polyethylene as a function of polymer crystallinity.

    abstract：:In this study the friction, wear and surface mechanical behavior of medical-grade ultra-high molecular weight polyethylene (UHMWPE) (GUR 1050 resin) were evaluated as a function of polymer crystallinity. Crystallinity was controlled by heating UHMWPE to a temperature above its melting point and varying the hold time a...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2008.02.022

    authors： Kanaga Karuppiah KS,Bruck AL,Sundararajan S,Wang J,Lin Z,Xu ZH,Li X

    更新日期：2008-09-01 00:00:00

  • Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration.

    abstract：:Several processing technologies and engineering strategies have been combined to create scaffolds with superior performance for efficient tissue regeneration. Cartilage tissue is a good example of that, presenting limited self-healing capacity together with a high elasticity and load-bearing properties. In this work, ...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2018.03.047

    authors： Ribeiro VP,da Silva Morais A,Maia FR,Canadas RF,Costa JB,Oliveira AL,Oliveira JM,Reis RL

    更新日期：2018-05-01 00:00:00

  • pH-responsive Ag2S nanodots loaded with heat shock protein 70 inhibitor for photoacoustic imaging-guided photothermal cancer therapy.

    abstract：:Heat-treated cancer cells have thermo-resistance due to the up-regulated levels of heat shock proteins (HSP) resulting in low therapeutic efficiency and ineffective ablation of tumors. In this work, we report pH-responsive Ag2S nanodots (Ag2S NDs) loaded with HSP70 inhibitor (QE-PEG-Ag2S) for enhanced photothermal can...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2020.08.007

    authors： Zhong Y,Zou Y,Liu L,Li R,Xue F,Yi T

    更新日期：2020-10-01 00:00:00

  • In vivo quantification of hydrogen gas concentration in bone marrow surrounding magnesium fracture fixation hardware using an electrochemical hydrogen gas sensor.

    abstract：:Magnesium (Mg) medical devices are currently being marketed for orthopedic applications and have a complex degradation process which includes the evolution of hydrogen gas (H2). The effect of H2 exposure on relevant cell types has not been studied; and the concentration surrounding degrading Mg devices has not been qu...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2018.04.032

    authors： Zhao D,Brown A,Wang T,Yoshizawa S,Sfeir C,Heineman WR

    更新日期：2018-06-01 00:00:00

  • Design and characterization of sulfobetaine-containing terpolymer biomaterials.

    abstract：:A methacrylic terpolymer system with non-fouling interfacial properties was synthesized by the random copolymerization of hexyl methacrylate, methyl methacrylate and sulfobetaine methacrylate (a monomer bearing a zwitterionic pendant group). Polymers were synthesized from feeds containing 0-15 mol.% of the zwitterion-...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2012.03.052

    authors： Heath DE,Cooper SL

    更新日期：2012-08-01 00:00:00

  • Development of bioactive and biodegradable chitosan-based injectable systems containing bioactive glass nanoparticles.

    abstract：:There is increasing interest in the development of new tissue engineering strategies to deliver cells and bioactive agents encapsulated in a biodegradable matrix through minimally invasive procedures. The present work proposes to combine chitosan-beta-glycerophosphate salt formulations with bioactive glass nanoparticl...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2008.08.006

    authors： Couto DS,Hong Z,Mano JF

    更新日期：2009-01-01 00:00:00

  • Simulation of discontinuous damage incorporating residual stresses in circumferentially overstretched atherosclerotic arteries.

    abstract：:When a balloon-angioplasty is performed, the arterial wall is overstretched and thereby damaged, which leads to a stiffness reduction in the arterial layers. An anisotropic damage model able to reflect the main damage mechanisms in overstretched arterial walls is used in combination with a polyconvex hyperelastic stor...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2006.06.005

    authors： Balzani D,Schröder J,Gross D

    更新日期：2006-11-01 00:00:00

  • Cell-instructive pectin hydrogels crosslinked via thiol-norbornene photo-click chemistry for skin tissue engineering.

    abstract：:Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix components. This paper describes the synthesis and photocrosslinking of cell-instructive pectin hydrogels using cel...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2017.11.016

    authors： Pereira RF,Barrias CC,Bártolo PJ,Granja PL

    更新日期：2018-01-15 00:00:00

  • Prospects of nonmulberry silk protein sericin-based nanofibrous matrices for wound healing - In vitro and in vivo investigations.

    abstract：:Recently, the progress in biomaterials for biomedical applications brings the focus of the research community toward nanomaterials. The nanofibrous matrices offer certain advantages (structural similarity to extracellular matrix, high surface area-to-volume ratio, increased elasticity, biostability, and strength) comp...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2018.07.047

    authors： Sapru S,Das S,Mandal M,Ghosh AK,Kundu SC

    更新日期：2018-09-15 00:00:00

  • On the role of RhoA/ROCK signaling in contact guidance of bone-forming cells on anisotropic Ti6Al4V surfaces.

    abstract：:Patterned surfaces direct cell spatial dynamics, yielding cells oriented along the surface geometry, in a process known as contact guidance. The Rho family of GTPases controls the assembly of focal adhesions and cytoskeleton dynamics, but its role in modulating bone-cell alignment on patterned surfaces remains unknown...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2010.11.035

    authors： Calzado-Martín A,Méndez-Vilas A,Multigner M,Saldaña L,González-Carrasco JL,González-Martín ML,Vilaboa N

    更新日期：2011-04-01 00:00:00

  • Modified bacterial outer membrane vesicles induce autoantibodies for tumor therapy.

    abstract：:Using monoclonal antibodies to block tumor angiogenesis has yielded effective antitumor effects. However, this treatment method has long cycles and is very expensive; therefore, its long-term and extensive application is limited. In this study, we developed a nanovaccine using bacterial biomembranes as carriers for an...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2020.03.030

    authors： Huang W,Shu C,Hua L,Zhao Y,Xie H,Qi J,Gao F,Gao R,Chen Y,Zhang Q,Li W,Yuan M,Ye C,Ma Y

    更新日期：2020-05-01 00:00:00

  • Corneal reinforcement using an acellular dermal matrix for an analysis of biocompatibility, mechanical properties, and transparency.

    abstract：:The aim of this study was to analyze the viability of using an acellular dermal matrix (ADM) as a reinforcement material for peripheral corneal thinning disease. The complete removal of cell components was confirmed by hematoxylin and eosin (H&E) and 4',6-diamidino-2-phenylindole (DAPI) staining. Transmission electron...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2012.05.004

    authors： Liu Z,Ji J,Zhang J,Huang C,Meng Z,Qiu W,Li X,Wang W

    更新日期：2012-09-01 00:00:00

  • Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering.

    abstract：:Tissue engineered vascular grafts (TEVGs) represent a promising therapeutic option for emergency vascular intervention. Although the application of small-diameter TEVGs using patient-specific primary endothelial cells (ECs) to prevent thrombosis and occlusion prior to implantation could be hindered by the long time co...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2020.11.007

    authors： Luo J,Shi X,Lin Y,Yuan Y,Kural MH,Wang J,Ellis MW,Anderson CW,Zhang SM,Riaz M,Niklason LE,Qyang Y

    更新日期：2021-01-01 00:00:00

  • Preparation of designed poly(D,L-lactide)/nanosized hydroxyapatite composite structures by stereolithography.

    abstract：:The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network struc...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章

    doi：10.1016/j.actbio.2012.12.004

    authors： Ronca A,Ambrosio L,Grijpma DW

    更新日期：2013-04-01 00:00:00

  • Hydrogels in calcium phosphate moldable and injectable bone substitutes: Sticky excipients or advanced 3-D carriers?

    abstract：:The combination of hydrogels and calcium phosphate particles is emerging as a well-established trend for bone substitutes. Besides acting as binders for the inorganic phase, hydrogels within these hybrid materials can modulate cell colonization physically and biologically. The influence of hydrogels on the healing pro...

    journal_title：Acta biomaterialia

    pub_type： 杂志文章,评审

    doi：10.1016/j.actbio.2012.11.022

    authors： D'Este M,Eglin D

    更新日期：2013-03-01 00:00:00