Inhibition of LPS-induced proinflammatory responses of J774.2 macrophages by immobilized enzymatically tailored pectins.

abstract：:As the potential range of stem cell applications in tissue engineering continues to grow, the appropriate scaffolding choice is necessary to create tightly defined artificial microenvironments for each target organ. These microenvironments determine stem cell fate via control over differentiation. In this study we exa...

journal_title：Acta biomaterialia

authors： Nam J,Johnson J,Lannutti JJ,Agarwal S

更新日期：2011-04-01 00:00:00

abstract：:The majority of in vitro studies assessing cancer treatments are performed in two-dimensional (2D) monolayers and are subsequently validated in in vivo animal models. However, 2D models fail to accurately model the tumour microenvironment. Furthermore, animal models are not directly applicable to mimic the human scena...

journal_title：Acta biomaterialia

authors： Costard LS,Hosn RR,Ramanayake H,O'Briena B C FJ,Curtin CM

更新日期：2021-01-20 00:00:00

abstract：:We fabricated three-dimensional microtissues with the aim to replicate in vitro the composition and the functionalities of the tumor microenvironment. By arranging either normal fibroblasts (NF) or cancer-activated fibroblasts (CAF) in two different three dimensional (3D) configurations, two kinds of micromodules were...

journal_title：Acta biomaterialia

authors： Brancato V,Garziano A,Gioiella F,Urciuolo F,Imparato G,Panzetta V,Fusco S,Netti PA

更新日期：2017-01-01 00:00:00

abstract：:In this work, we have evaluated the haemocompatibility of different surface modifications, intended for biomaterials and bioanalytical applications. Polystyrene slides were coated with thin hydrogel films by self-initiated photografting and photopolymerization (SIPGP) of four different monomers. The hydrogel surface m...

journal_title：Acta biomaterialia

authors： Faxälv L,Ekblad T,Liedberg B,Lindahl TL

更新日期：2010-07-01 00:00:00

abstract：:The innate biological response to peripheral nerve injury involves a complex interplay of multiple molecular cues to guide neurites across the injury gap. Many current strategies to stimulate regeneration take inspiration from this biological response. However, little is known about the balance of cell-matrix and Schw...

journal_title：Acta biomaterialia

authors： Romano NH,Madl CM,Heilshorn SC

更新日期：2015-01-01 00:00:00

abstract：:Chronically implanted neural multi-electrode arrays (MEA) are an essential technology for recording electrical signals from neurons and/or modulating neural activity through stimulation. However, current MEAs, regardless of the type, elicit an inflammatory response that ultimately leads to device failure. Traditionall...

journal_title：Acta biomaterialia

authors： Du ZJ,Kolarcik CL,Kozai TDY,Luebben SD,Sapp SA,Zheng XS,Nabity JA,Cui XT

更新日期：2017-04-15 00:00:00

abstract：:Dentin contains 1-2μm diameter tubules extending from the pulp cavity to near the junction with enamel. Peritubular dentin (PTD) borders the tubule lumens and is surrounded by intertubular dentin (ITD). Differences in PTD and ITD composition and microstructure remain poorly understood. Here, a (∼200nm)(2), 10.1keV syn...

journal_title：Acta biomaterialia

authors： Stock SR,Deymier-Black AC,Veis A,Telser A,Lux E,Cai Z

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:Chondrocyte dedifferentiation presents a major barrier in engineering functional cartilage constructs. To mitigate the effects of dedifferentiation, this study employed a post-expansion aggregate culture step to enhance the chondrogenic phenotype of passaged articular chondrocytes (ACs) before their integrat...

journal_title：Acta biomaterialia

authors： Huang BJ,Hu JC,Athanasiou KA

更新日期：2016-10-01 00:00:00

abstract：:With the increasing demand for novel bone repair solutions that overcome the drawbacks of current grafting techniques, the design of artificial bone scaffolds is a central focus in bone regeneration research. Calcium phosphate scaffolds are interesting given their compositional similarity with bone mineral. The majori...

journal_title：Acta biomaterialia

authors： Rustom LE,Poellmann MJ,Wagoner Johnson AJ

更新日期：2019-01-01 00:00:00

abstract：:The physico-chemical processes and phenomena occurring at the interface of metallic biomedical implants and the body dictate their successful integration in vivo. Changes in the surface potential and the associated redox reactions at metallic implants can significantly influence several aspects of biomaterial/cell int...

journal_title：Acta biomaterialia

authors： Haeri M,Gilbert JL

更新日期：2013-11-01 00:00:00

abstract：:Molecular traps can control activity and abundance of many biological factors. Here, we report the development of a generic opto-trap to reversibly bind and release biomolecules with high spatiotemporal control by illumination with non-invasive and cell-compatible red and far-red light. We use the Arapidopsis thaliana...

journal_title：Acta biomaterialia

authors： Beyer HM,Thomas OS,Riegel N,Zurbriggen MD,Weber W,Hörner M

更新日期：2018-10-01 00:00:00

abstract：:The use of biodegradable beta-tricalcium phosphate (β-TCP) scaffolds holds great promise for bone tissue engineering. However, the effects of β-TCP on bone and endothelial cells are not fully understood. This study aimed to investigate cell proliferation and differentiation of mono- or co-cultured human-bone-marrow-de...

journal_title：Acta biomaterialia

authors： Kang Y,Kim S,Fahrenholtz M,Khademhosseini A,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:Cardiac tissue engineering typically utilizes protein-rich scaffolding materials and growth factors to improve cardiac tissue function in vitro and in vivo. The objectives of this preliminary study were (i) to investigate the potential of porcine small intestinal submucosa gel (SIS gel) in cardiac tissue engineering a...

journal_title：Acta biomaterialia

authors： Crapo PM,Wang Y

更新日期：2010-06-01 00:00:00

abstract：:Glass-ceramic macroporous scaffolds for tissue engineering have been developed using a polyurethane sponge template and bioactive glass powders. The starting glass (CEL2) belongs to the system SiO(2)-P(2)O(5)-CaO-MgO-Na(2)O-K(2)O and has been synthesised by a conventional melting-quenching route. A slurry of CEL2 powd...

journal_title：Acta biomaterialia

authors： Vitale-Brovarone C,Verné E,Robiglio L,Appendino P,Bassi F,Martinasso G,Muzio G,Canuto R

更新日期：2007-03-01 00:00:00

abstract：:The calcareous spicules from sponges, e.g. from Sycon raphanus, are composed of almost pure calcium carbonate. In order to elucidate the formation of those structural skeletal elements, the function of the enzyme carbonic anhydrase (CA), isolated from this species, during the in vitro calcium carbonate-based spicule f...

journal_title：Acta biomaterialia

authors： Müller WE,Schlossmacher U,Schröder HC,Lieberwirth I,Glasser G,Korzhev M,Neufurth M,Wang X

更新日期：2014-01-01 00:00:00

abstract：:Polylactide (PLA) polymers containing five distinct lengths of fluorinated (from C3F7 to C13F27) and non-fluorinated (C6H13) end-groups were successfully synthesized by ring-opening polymerization of d,l-lactide. Fluorination was expected to increase the encapsulation efficiency of perfluorohexane (PFH). 150 nm nanoca...

journal_title：Acta biomaterialia

authors： Picheth G,Houvenagel S,Dejean C,Couture O,Alves de Freitas R,Moine L,Tsapis N

更新日期：2017-12-01 00:00:00

abstract：UNLABELLED:Cardiovascular disease is the leading cause of death in the world. In this study, coaxial electrospinning is employed to fabricate fibers in a core-shell structure with polyvinyl alcohol (PVA) in the core and gelatin in the shell for evaluation as a potential vascular tissue engineering construct. PVA, a syn...

journal_title：Acta biomaterialia

authors： Merkle VM,Tran PL,Hutchinson M,Ammann KR,DeCook K,Wu X,Slepian MJ

更新日期：2015-11-01 00:00:00

abstract：:The development of functional therapies for corneal repair and regeneration is a pressing issue. Corneal stroma provides the principal functions of the cornea. However, because of the highly organized nature of the stromal matrix, the attempts to reproduce corneal stroma might follow a scar model. Here, we have develo...

journal_title：Acta biomaterialia

authors： Cui Z,Zeng Q,Liu S,Zhang Y,Zhu D,Guo Y,Xie M,Mathew S,Cai D,Zhang J,Chen J

更新日期：2018-07-15 00:00:00

abstract：:To search for potential non-viral nucleic acids carriers, a series of novel cationic polymers, multi-armed poly(aspartate-graft-oligoethylenimine) (MP-g-OEI) copolymers were designed and synthesized by grafting different types of oligoethylenimine (OEI) to a multi-armed poly(l-aspartic acid) backbone. The as-synthesiz...

journal_title：Acta biomaterialia

authors： Dong X,Lin L,Chen J,Tian H,Xiao C,Guo Z,Li Y,Wei Y,Chen X

更新日期：2013-06-01 00:00:00

abstract：:This study concerns the preparation and in vitro characterization of an apatite-wollastonite-2M bioactive glass ceramic which is intended to be used for the regeneration of hard tissue (i.e. in dental and craniomaxillofacial surgery). This bioglass ceramic has been obtained by appropriate thermal treatment through the...

journal_title：Acta biomaterialia

authors： Magallanes-Perdomo M,De Aza AH,Mateus AY,Teixeira S,Monteiro FJ,De Aza S,Pena P

更新日期：2010-06-01 00:00:00

abstract：:Evaluations of the osteoblast-like cell responses and osteoconductivity of a non-woven silica gel fabric were carried out to determine its potential for application as a scaffold material for use in bone tissue engineering. The silica gel solution was prepared by condensation following hydrolysis of tetraethyl orthosi...

journal_title：Acta biomaterialia

authors： Kang YM,Kim KH,Seol YJ,Rhee SH

更新日期：2009-01-01 00:00:00

abstract：:Tissue engineered vascular grafts (TEVGs) represent a promising therapeutic option for emergency vascular intervention. Although the application of small-diameter TEVGs using patient-specific primary endothelial cells (ECs) to prevent thrombosis and occlusion prior to implantation could be hindered by the long time co...

journal_title：Acta biomaterialia

authors： Luo J,Shi X,Lin Y,Yuan Y,Kural MH,Wang J,Ellis MW,Anderson CW,Zhang SM,Riaz M,Niklason LE,Qyang Y

更新日期：2021-01-01 00:00:00

abstract：:Biodegradable PHBHHx (poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)) nanoparticles containing insulin phospholipid complex were loaded in chitosan-based thermosensitive hydrogels for long-term sustained and controlled delivery of insulin. The injectable hydrogels, prepared by adding β-glycerophosphate disodium salt (G...

journal_title：Acta biomaterialia

authors： Peng Q,Sun X,Gong T,Wu CY,Zhang T,Tan J,Zhang ZR

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints. The standard of care, vascularized bone grafts, is limited by donor site morbidity and restricted availability. The aim of this study was to generate and test engineered, axially vascularized SVF cells-based bone substitutes...

journal_title：Acta biomaterialia

authors： Ismail T,Osinga R,Todorov A Jr,Haumer A,Tchang LA,Epple C,Allafi N,Menzi N,Largo RD,Kaempfen A,Martin I,Schaefer DJ,Scherberich A

更新日期：2017-11-01 00:00:00

abstract：:Degradation characteristics in response to electron beam sterilization of designed and biodegradable aliphatic polyester scaffolds are relevant for clinically successful synthetic graft tissue regeneration. Scaffold degradation in vitro and in vivo were documented and correlated to the macroscopic structure and chemic...

journal_title：Acta biomaterialia

authors： Dånmark S,Finne-Wistrand A,Schander K,Hakkarainen M,Arvidson K,Mustafa K,Albertsson AC

更新日期：2011-05-01 00:00:00

abstract：:Throughout the process of aging, dynamic changes of bone material, micro- and macro-architecture result in a loss of strength and therefore in an increased likelihood of fragility fractures. To date, precise contributions of age-related changes in bone (re)modeling and (de)mineralization dynamics to this fragility inc...

journal_title：Acta biomaterialia

authors： Asgharzadeh P,Röhrle O,Willie BM,Birkhold AI

更新日期：2020-04-01 00:00:00

abstract：:One of the challenges of using bioactive bone cements is adjusting their handling properties for clinical application. To resolve the poorer handling properties of bioactive bone cements we developed a novel bioactive bone cement containing a unique polymethylmethacrylate (PMMA) powder, termed SPD-PMMA (40 μm in diame...

journal_title：Acta biomaterialia

authors： Fukuda C,Goto K,Imamura M,Neo M,Nakamura T

更新日期：2011-10-01 00:00:00

abstract：:In this study, the Cu-doping mechanism of Biphasic Calcium Phosphate (BCP) was thoroughly investigated, as was its ionic release behavior, in order to elucidate cytotoxicity features of these bioceramics. BCP are composed of hydroxyapatite (Ca10(PO4)6(OH)2) and β-TCP (Ca3(PO4)2). The two phases present two different d...

journal_title：Acta biomaterialia

authors： Gomes S,Vichery C,Descamps S,Martinez H,Kaur A,Jacobs A,Nedelec JM,Renaudin G

更新日期：2018-01-01 00:00:00

abstract：:The humid atmosphere and permanent occurrence of chewing forces in the oral environment lead to degradation of ceramics used for prosthetic restorations. The aim of this in vitro study was to evaluate the influence of artificial aging on the load-bearing capacity of four-unit bridges, with both undamaged and predamage...

journal_title：Acta biomaterialia

authors： Kohorst P,Dittmer MP,Borchers L,Stiesch-Scholz M

更新日期：2008-09-01 00:00:00

abstract：:Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context, in this work, liposomes of differen...

journal_title：Acta biomaterialia

authors： Yang K,Mesquita B,Horvatovich P,Salvati A

更新日期：2020-04-01 00:00:00