Abstract：
:Osteoarthritis is the most common joint disease affecting roughly one sixth of the human population. It is also the most common arthritis affecting the temporomandibular joint, often leading to severe pain and the inability to masticate. Animal models are essential to investigate the disease in part because they lend themselves to genetic manipulation and various treatments and also because of the lack of availability of human specimens from various stages of the disease. The wide range of osteoarthritis models alone are a proof of its multifactorial origin. Manipulation of collagen, cytokine, matrix metalloproteinase and small leucine-rich repeat proteoglycan genes can all have an effect on the development and persistence of arthritis. Surgical models also exist, highlighting the importance of normal anatomy and trauma. Here we review the English literature of murine models of temporomandibular joint arthritis with special attention to the genetic and molecular background of osteoarthritis.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Ghassemi Nejad S,Kobezda T,Tar I,Szekanecz Zdoi
10.1016/j.jbspin.2016.05.016subject
Has Abstractpub_date
2017-03-01 00:00:00pages
145-151issue
2eissn
1297-319Xissn
1778-7254pii
S1297-319X(16)30111-7journal_volume
84pub_type
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