Abstract：
:Conventional chemotherapies are no longer the only treatment in multiple myelomatosis. High-dose chemotherapy and autologous transplantation are not curative but do increase relapse-free survival time in young patients. Thalidomide is efficacious in refractory and relapsing myeloma and its evaluation is going on. Curative and preventive treatments of skeletal events, infections and anemia improve quality of life. All together, these strategies imply therapeutic knowledge and choices but allow an about 5-year-long median survival time in modern studies. Treatment options for myeloma now include, not only conventional chemotherapy regimens, but also novel symptomatic drugs and strategies that increase survival and/or quality of life, although they fail to provide a cure. In parallel with this expansion of the treatment armamentarium, physicians must acquire the knowledge needed to select the best treatment for the individual patient. After reviewing the rationale, effectiveness, and safety of each of these treatments, we will discuss the indications that we believe are legitimate.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Clerc D,Fermand JP,Mariette Xdoi
10.1016/s1297-319x(03)00018-6subject
Has Abstractpub_date
2003-06-01 00:00:00pages
175-86issue
3eissn
1297-319Xissn
1778-7254pii
S1297319X03000186journal_volume
70pub_type
杂志文章,评审相关文献
JOINT BONE SPINE文献大全abstract：OBJECTIVES:To develop recommendations for TNFalpha antagonist therapy in patients with spondyloarthropathies. METHODS:The Delphi consensus procedure was used to select questions, to which evidence-based answers were sought in the literature. Expert opinion was used when needed to estimate the risks and benefits of TNF...
journal_title：Joint bone spine
pub_type： 杂志文章,实务指引
doi：10.1016/j.jbspin.2006.02.005
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To determine the comparative efficacy of non-biologic treatments for remission maintenance in ANCA-associated vasculitis. METHODS:We identified all randomized trials comparing leflunomide, azathioprine, methotrexate or mycophenolate mofetil in adult patients with granulomatosis with polyangiitis or microscop...
journal_title：Joint bone spine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jbspin.2013.11.006
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To analyze the influence of anthropometry at birth on bone status and physical activity aptitudes of adult women. METHODS:Our population was composed of 70 women (17-29 years): 40 athletes and 30 controls. Athletes participated in various long-lasting and high-level weight-bearing sports (10.2 ± 2.2h ours/we...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.07.020
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To design a quality-of-life (QOL) instrument specific for patients with knee or hip osteoarthritis and to assess its validity and reproducibility. METHODS:One-on-one or group interviews were conducted with 79 patients and 28 healthcare professionals. Of the 80 potential items identified from the results, 46 ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2006.01.027
更新日期：2006-12-01 00:00:00
abstract：INTRODUCTION:Rheumatoid arthritis (RA) generates a heavy socioeconomic burden. The ability to predict the frequency and severity of socioeconomic effects due to RA is crucial to the development of public health policies. OBJECTIVE:To conduct a systematic literature review of data on the prevalence, incidence, and seve...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2016.07.007
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:Uveitis is a frequent extra rheumatological manifestation in axial Spondyloarthritis (SpA). The aim of study was to evaluate the prevalence and incidence of uveitis over the first five years of a prospective nationwide cohort of patients with high suspicion of early axial SpA, and to evaluate its associated f...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.105100
更新日期：2020-11-06 00:00:00
abstract：OBJECTIVES:Some immunological abnormalities have been described in seronegative spondyloarthropathies (SpA). The aim of this study is to determine the serum levels of IL-1beta, TNF-alpha and IL-8, which are proinflammatory cytokines in active and inactive patients with SpA, to compare the results with those of controls...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(02)00431-1
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVES:Accumulating evidence suggests that gout is associated with increased overall and cardiovascular mortality. Using data from a large consecutive cohort of gout sufferers who were followed for 8 years, we investigated mortality among gout sufferers and compared the results with data from the general population...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2011.01.007
更新日期：2011-12-01 00:00:00
abstract：UNLABELLED:Arthritis, tenosynovitis, and bursitis due to sea urchin spine injuries have unique pathological features and run a chronic course until the spines are removed. Of the 40 cases of sea urchin spine-related clinical symptoms published to date, only 12 had osteoarticular symptoms. PATIENTS AND METHODS:We studi...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:Anti-citrullinated protein/peptide antibodies (ACPA) represent an important tool for the diagnosis of rheumatoid arthritis (RA) and the presence of multiple ACPA specificities is highly correlated with the evolution towards RA. However, little is known about the association of single specificities with disea...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2017.07.009
更新日期：2018-07-01 00:00:00
abstract：:A case of severe hyperparathyroidism (HPT), secondary to chronic renal failure, with massive distal phalangeal osteolysis is reported. After parathyroidectomy, brachydactyly and osteosclerosis of the distal phalanges were observed; the phalanx of the thumbs healed with shortened and sclerotic beaked appearance. These ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(03)00023-x
更新日期：2003-03-01 00:00:00
abstract：:We present a case of giant chronic expanding hematoma occurring in the left lateral thigh without any history of trauma or chronic medical disease. In our case, a diagnosis was unable to perform through conventional diagnosis method, which was confirmed by histopathological examination after successful surgical treatm...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.01.041
更新日期：2008-01-01 00:00:00
abstract：:The SERMs (selective estrogen receptor modulators) are a new class of molecules that bind to the estrogen receptor, resulting in an estradiol agonist or antagonist response according to the target tissue. Raloxifene, a new SERM, has been shown to prevent postmenopausal bone loss, to reduce the risk of vertebral fractu...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:A component of ATP, phosphate is at the hub of the energy-related mechanisms operative in muscle cells. Together with calcium, phosphate is involved in bone tissue mineralization: thus, a chronic alteration in the metabolism of phosphate can induce bone and joint disorders. Diagnosis of chronic hypophosphatemia. Serum...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/s1297-319x(01)00274-3
更新日期：2001-05-01 00:00:00
abstract：:Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in various populations and is dramatically increasing in many countries, mostly related to age and obesity, leading to an increased number of pe...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2017.08.002
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Calcium pyrophosphate dihydrate crystal deposition disease (CPPD-CDD) has been associated to hypercalcemia. Familial hypocalciuric hypercalcemia (FHH) is a rare but important consideration in the differential diagnosis of hypercalcemia. This autosomal dominantly inherited condition is characterized by elevat...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2009.02.001
更新日期：2009-12-01 00:00:00
abstract：:Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases, most of which differ from the main adult-onset inflammatory joint diseases. Nonsystemic forms of JIA (oligoarthritis, polyarthritis with or without rheumatoid factors, and spondyloarthropathies) are managed similarly to adult-onset rheumatoid ar...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.09.002
更新日期：2010-12-01 00:00:00
abstract：:The prominent role for mast cells in the inflammatory response has been increasingly well documented in recent years. Mast cells not only contribute to maintain homeostasis via degranulation and to generate IgE-mediated allergic reactions, but also sit at a major crossroads for both innate and adaptive immune response...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2012.08.013
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To compare the frequency of different autoantibodies in a group of patients with Jaccoud's arthropathy (JA) secondary to systemic lupus erythematosus (SLE) with those without JA. METHODS:A group of SLE patients with JA was compared with another group of SLE patients without this complication, matched by age ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.11.003
更新日期：2009-07-01 00:00:00
abstract：:Neural fibrolipoma or fibrolipomatous hamartoma is an uncommon benign tumor that usually arises in the median nerve. Fibrofatty tissue proliferates around the nerve and infiltrates the epineurium and perineurium. We report a case of fibrolipomatous hamartoma of the left median nerve in an 18-year-old woman. Our object...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2006.02.012
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To assess if the use of biological marker of bone resorption (CTX) feedback is a mean to improve persistence on monthly oral ibandronate. METHODS:One year prospective multicenter study using a cluster randomisation design with physicians as randomized units into two groups, A and B; in group B, physicians us...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jbspin.2011.05.001
更新日期：2012-07-01 00:00:00
abstract：:Drug-induced aseptic meningitis is uncommon and occurs primarily in patients with autoimmune disease. We report the first known case of leflunomide-induced aseptic meningitis, in a patient with rheumatoid arthritis. ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/S1297-319X(03)00127-1
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVES:Patients with acromegaly appear to be at increased risk of vertebral fractures despite normal bone mineral density. We investigated the prevalence of vertebral fractures in a cohort of acromegalic patients under 80 years of age. METHODS:Monocentric cross-sectional study performed at Nantes University Hospit...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.04.020
更新日期：2020-12-01 00:00:00
abstract：:Cow's milk is often severely criticized as a cause of multiple health problems, including an increased risk of fractures. A close look at the scientific literature shows a striking contradiction. On the one hand, experimental studies of surrogate markers (e.g., bone turnover markers and bone mineral density [BMD]) usu...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2016.06.006
更新日期：2017-05-01 00:00:00
abstract：:Parkinson's disease is the most common neurodegenerative disease after Alzheimer's disease. On the long term, it may be complicated by various musculoskeletal problems, such as osteoporotic fractures, that have significant socioeconomic consequences. Indeed, patients suffering from Parkinson's disease have a higher fr...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2015.03.009
更新日期：2015-12-01 00:00:00
abstract：:We report on a 46-year-old woman, who developed streptococcus B septic polyarthritis in the context of septicemia of urinary origin. This case revealed a Good's syndrome whose diagnosis was made on the basis of a profound hypogammaglobulinaemia, a large decrease of peripheral B cells and a thymoma disclosed on chest c...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2012.03.009
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity. METHODS:A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF perio...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2015.01.023
更新日期：2015-10-01 00:00:00
abstract：:We report on an unusual case of a 40-year-old Caucasian male displaying severe Kawasaki-like symptoms. The disease lasted for seven years before diffuse coronary aneurysms occurred, leading to the patient's death, despite ongoing treatment by intravenous immunoglobulins (IVIGs). The patient had also been suffering fro...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2009.01.006
更新日期：2009-10-01 00:00:00
abstract：:We describe a patient in whom sporadic Creutzfeldt-Jakob disease (sCJD) occurred one year after the onset of etanercept therapy for rheumatoid arthritis (RA). This association could be a chance occurrence. However, TNF-alpha has been implicated in the pathogenesis of neurodegeneration in sCJD and etanercept might wors...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2009.05.016
更新日期：2010-03-01 00:00:00
abstract：UNLABELLED:The role of epidural fibrosis in postoperative sciatica is unclear. Few therapeutic trials have been published. We evaluated the mechanical effects of forceful saline injections through the sacrococcygeal hiatus comparatively with glucocorticoid injections. PATIENTS AND METHODS:Forty-seven patients with pos...
journal_title：Joint bone spine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s1297-319x(00)00234-7
更新日期：2001-02-01 00:00:00
