Abstract：
:The prominent role for mast cells in the inflammatory response has been increasingly well documented in recent years. Mast cells not only contribute to maintain homeostasis via degranulation and to generate IgE-mediated allergic reactions, but also sit at a major crossroads for both innate and adaptive immune responses. The part played by mast cells in chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis identifies mast cells as a valuable treatment target in these diseases. Tyrosine-kinase inhibitors targeting the c-Kit mast cell receptor have been found effective in treating rheumatoid arthritis, asthma, and multiple sclerosis. When used in combination with other available drugs, tyrosine-kinase inhibitors may improve the therapeutic management of these diseases.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Frenzel L,Hermine Odoi
10.1016/j.jbspin.2012.08.013subject
Has Abstractpub_date
2013-03-01 00:00:00pages
141-5issue
2eissn
1297-319Xissn
1778-7254pii
S1297-319X(12)00203-5journal_volume
80pub_type
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