Abstract:
BACKGROUND:We investigated the associations between daily sales of respiratory medication and air pollutants in the Brussels-Capital Region between 2005 and 2011. METHODS:We used over-dispersed Poisson Generalized Linear Models to regress daily individual reimbursement data of prescribed asthma and COPD medication from the social security database against each subject's residential exposure to outdoor particulate matter (PM10) or NO2 estimated, by interpolation from monitoring stations. We calculated cumulative risk ratios (RR) and their 95% confidence intervals (CI) for interquartile ranges (IQR) of exposure for different windows of past exposure for the entire population and for seven age groups. RESULTS:Median daily concentrations of PM10 and NO2 were 25μg/m(3) (IQR=17.1) and 38μg/m(3) (IQR=20.5), respectively. PM10 was associated with daily medication sales among individuals aged 13 to 64y. For NO2, significant associations were observed among all age groups except >84y. The highest RR were observed for NO2, among adolescents, including three weeks lags (RR=1.187 95%CI: 1.097-1.285). CONCLUSION:The associations found between temporal changes in exposure to air pollutants and daily sales of respiratory medication in Brussels indicate that urban air pollution contributes to asthma and COPD morbidity in the general population.
journal_name
Environ Intjournal_title
Environment internationalauthors
Casas L,Simons K,Nawrot TS,Brasseur O,Declerck P,Buyl R,Coomans D,Nemery B,Van Nieuwenhuyse Adoi
10.1016/j.envint.2016.06.019subject
Has Abstractpub_date
2016-09-01 00:00:00pages
576-582eissn
0160-4120issn
1873-6750pii
S0160-4120(16)30237-9journal_volume
94pub_type
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