Exosomes as a biomarker platform for detecting epidermal growth factor receptor-positive high-grade gliomas.

abstract：OBJECT:The average 65-year-old patient with moderate dementia can look forward to only 1.4 quality-adjusted life years (QALYs), that is, longevity times quality of life. Some of these patients suffer from normal-pressure hydrocephalus (NPH) and respond dramatically to shunt insertion. Currently, however, NPH cannot be ...

journal_title：Journal of neurosurgery

authors： Stein SC,Burnett MG,Sonnad SS

更新日期：2006-12-01 00:00:00

abstract：:Thirty-eight patients underwent transsphenoidal microsurgical treatment of non-neoplastic intrasellar cysts: 36 had cyst drainage and biopsy of the cyst wall, and in two the cyst was totally removed. Surgical morbidity was 8%. The mean follow-up time was 46.3 months; 100% patient follow-up evaluation was achieved. Six...

journal_title：Journal of neurosurgery

authors： Baskin DS,Wilson CB

更新日期：1984-01-01 00:00:00

abstract：:The application of several recent advances in cell biology, brain implantation, and cell-mediated tumor immunotherapy requires successful and reproducible placement of viable cell suspensions into brain. Stereotaxic implantation is being used to inject cytotoxic lymphocytes into gliomas and to replace dopaminergic cel...

journal_title：Journal of neurosurgery

authors： Plunkett RJ,Weber RJ,Oldfield EH

更新日期：1988-08-01 00:00:00

abstract：OBJECT:Physicians are often solicited by patients or colleagues for clinical recommendations they would make for themselves if faced by a clinical situation. The act of making a recommendation can alter the clinical course being taken. The authors sought to understand this dynamic across different neurosurgical scenari...

journal_title：Journal of neurosurgery

authors： Tanweer O,Wilson TA,Kalhorn SP,Golfinos JG,Huang PP,Kondziolka D

更新日期：2015-03-01 00:00:00

abstract：OBJECT:The purpose of this study was to determine if magnetic source (MS) imaging could provide useful information in the planning and performance of gamma knife radiosurgery (GKS) for epilepsy. METHODS:Magnetic source imaging of interictal epileptiform dipoles was studied in 53 epilepsy surgery candidates. All patien...

journal_title：Journal of neurosurgery

authors： Smith JR,King DW,Park YD,Lee MR,Lee GP,Jenkins PD

更新日期：2000-12-01 00:00:00

abstract：OBJECT:Activation of signaling by the epidermal growth factor receptor (EGFR) through gene amplification or rearrangement is common in human malignancy, especially in a large fraction of de novo glioblastomas multiforme (GBMs). The most common mutant EGFR, (AEGFR, also known as de2-7 EGFR and EGFRvIII) lacks a portion ...

journal_title：Journal of neurosurgery

authors： Nagane M,Narita Y,Mishima K,Levitzki A,Burgess AW,Cavenee WK,Huang HJ

更新日期：2001-09-01 00:00:00

abstract：OBJECT:Brain metastases from gastrointestinal cancers are rare. However, the incidence is increasing because patients with gastrointestinal carcinoma tend to live longer due to earlier diagnosis and more effective treatment of systemic disease. The purpose of this study was to evaluate the efficacy of Gamma Knife surge...

journal_title：Journal of neurosurgery

authors： Da Silva AN,Nagayama K,Schlesinger DJ,Sheehan JP

更新日期：2009-09-01 00:00:00

abstract：:Although in several histological studies of arteriovenous malformation (AVM) nidi the presence of compartments has been documented, no clinical study has been published. The present study was conducted to determine the presence of nidus compartments in clinical cases by using a new radiographic method. Two patients wi...

journal_title：Journal of neurosurgery

authors： Kakizawa Y,Nagashima H,Oya F,Ito K,Tanaka Y,Hongo K,Kobayashi S

更新日期：2002-04-01 00:00:00

abstract：:The authors describe the technique of a transantral transsphenoidal approach to the sella turcica. The advantages and potential complications are discussed. This procedure may also be applicable when dealing with tumors of the skull base and orbits. ...

journal_title：Journal of neurosurgery

authors： Hoyt TE,Turnbull FM,Kusske JA

更新日期：1983-12-01 00:00:00

abstract：OBJECT:In C7-T1 brachial plexus palsies, finger extension and flexion are absent. At the authors' institution, finger flexion has been successfully reconstructed by transferring the brachialis motor branch to the anterior interosseous nerve. However, there is no reliable method for restoring finger extension. In the pr...

journal_title：Journal of neurosurgery

authors： Dong Z,Gu YD,Zhang CG,Zhang L

更新日期：2010-07-01 00:00:00

abstract：OBJECT:In this report the authors explore the use of standardized plugging templates in formulating stereotactic radiosurgery dose plans for the Leksell gamma knife. METHODS:Unplugged gamma knife dose plans previously used in the treatment of patients with trigeminal neuralgia (TN) and vestibular schwannoma (VS) were ...

journal_title：Journal of neurosurgery

authors： Vaughan P,Hampshire A,Soanes T,Kemeny A,Radatz M,Rowe J,Walton L

更新日期：2002-12-01 00:00:00

abstract：:The authors used indicator fractionation techniques to determine blood flow in normal and bluntly traumatized spinal cords of Macaca rhesus monkeys. Normal flow rates were determined for several levels of spinal cord as well as differential values for white and gray matter from representative areas. Flow rates in trau...

journal_title：Journal of neurosurgery

authors： Bingham WG,Goldman H,Friedman SJ,Murphy S,Yashon D,Hunt WE

更新日期：1975-08-01 00:00:00

abstract：:The fourth Editor of the Journal of Neurosurgery offers short vignettes on the Editors who preceded and succeeded him. He recounts some of the challenges that were faced and changes that were made during his time as Editor. One of the major changes was production of the Journal via computer. ...

journal_title：Journal of neurosurgery

authors： Collins WF

更新日期：1994-07-01 00:00:00

abstract：OBJECT:Surgical mortality is a frequent outcome measure in studies of volume-outcome relationships, and the Agency for Healthcare Research and Quality has endorsed surgical mortality after craniotomies as an Inpatient Quality Indicator. Still, the frequency and causes of 30-day mortality after neurosurgical procedures ...

journal_title：Journal of neurosurgery

authors： Solheim O,Jakola AS,Gulati S,Johannesen TB

更新日期：2012-04-01 00:00:00

abstract：OBJECT:Delayed cerebral ischemia is a major cause of morbidity and death following aneurysmal subarachnoid hemorrhage and requires timely intervention for a successful outcome to be achieved. In this study the investigators compared the commonly used Fisher scale with 2 newer radiographic scales for the prediction of v...

journal_title：Journal of neurosurgery

authors： Kramer AH,Hehir M,Nathan B,Gress D,Dumont AS,Kassell NF,Bleck TP

更新日期：2008-08-01 00:00:00

abstract：:Pilomyxoid astrocytomas have been identified as a more aggressive variant of pilocytic astrocytomas that occur in infants and in young children. These tumors are characterized by a perivascular arrangement of pilocytic cells that has a monomorphous architecture with uniform, elongated bipolar cells loosely ranged with...

journal_title：Journal of neurosurgery

authors： Gottfried ON,Fults DW,Townsend JJ,Couldwell WT

更新日期：2003-08-01 00:00:00

abstract：OBJECT:This Phase II study was performed to determine the safety, tolerability, and efficacy of combining nimustine (ACNU)-carboplatin-vincristine-Interferon-beta (IFNbeta) chemotherapy. METHODS:Ninety-seven patients with Karnofsky Performance Scale scores of 50 or greater were enrolled in the study. Nimustine (60 mg/...

journal_title：Journal of neurosurgery

authors： Aoki T,Takahashi JA,Ueba T,Oya N,Hiraoka M,Matsui K,Fukui T,Nakashima Y,Ishikawa M,Hashimoto N

更新日期：2006-09-01 00:00:00

abstract：:The results of anterior cervical surgery for treatment of cervical spondylotic myelopathy (CSM) are assessed 1 to 7 years postoperatively in 32 patients. At follow-up review, 50% were improved after surgery and 50% were unimproved or had deteriorated in spite of surgery. The results could not be statistically linked t...

journal_title：Journal of neurosurgery

authors： Lunsford LD,Bissonette DJ,Zorub DS

更新日期：1980-07-01 00:00:00

abstract：:To determine the risk of intracranial hemorrhage in patients with malignant gliomas who are treated with anticoagulant drugs for late postoperative venous thromboembolism, the authors retrospectively reviewed the computerized data base of all patients with primary brain tumors seen at the University of California, San...

journal_title：Journal of neurosurgery

authors： Choucair AK,Silver P,Levin VA

更新日期：1987-03-01 00:00:00

abstract：:The management of ventriculoperitoneal (VP) shunt failure is a common problem in neurosurgical practice. On occasion, extraperitoneal sites for CSF diversion are required when shunting to the peritoneal cavity has failed after multiple attempts. The authors report a novel minimally invasive procedure allowing cannulat...

journal_title：Journal of neurosurgery

authors： Pillai A,Mathew G,Nachimuthu S,Kalavampara SV

更新日期：2017-03-17 00:00:00

abstract：:A patient with a subcutaneous sacrococcygeal ependymoma and metastasis to the inguinal lymph nodes is presented and his treatment is described. Previous reports on sacrococcygeal ependymoma are reviewed. ...

journal_title：Journal of neurosurgery

authors： Kramer GW,Rutten E,Sloof J

更新日期：1988-03-01 00:00:00

abstract：OBJECT:This prospective study is based on a consecutive series of 20 patients with pineal region tumors who underwent minimally invasive preferential management. The purpose of this report is to discuss the role of neuroendoscopic procedures in the management of pineal region tumors. METHODS:If the tumor markers alpha...

journal_title：Journal of neurosurgery

authors： Oi S,Shibata M,Tominaga J,Honda Y,Shinoda M,Takei F,Tsugane R,Matsuzawa K,Sato O

更新日期：2000-08-01 00:00:00

abstract：OBJECT:The aim of this paper was to validate the diffusion tensor imaging (DTI) model for delineation of the corticospinal tract using cortical and subcortical white matter electrical stimulation for the location of functional motor pathways. METHODS:The authors compare probabilistic versus deterministic DTI fiber tra...

journal_title：Journal of neurosurgery

authors： Mandelli ML,Berger MS,Bucci M,Berman JI,Amirbekian B,Henry RG

更新日期：2014-08-01 00:00:00

abstract：:Mechanical obstruction is a severe complication of ventricular catheter use. Its incidence was shown to be high in the 1960s and 1970s, with up to 41% of the catheters becoming obstructed within 10 years after surgery. The authors present what is to their knowledge the first reported case of a patient with failure of ...

journal_title：Journal of neurosurgery

authors： Zinn PO,Bozinov O,Burkhardt JK,Reisch R,Yaşargil MG,Bertalanffy H

更新日期：2010-04-01 00:00:00

abstract：OBJECT:It remains unclear whether malignant glioma cells can deliver tumor antigens efficiently to major histocompatibility complex (MHC) Class I molecules. To elucidate the mechanism of antigen presentation in malignant gliomas, the authors examined the expression of the transporter associated with antigen processing ...

journal_title：Journal of neurosurgery

authors： Satoh E,Mabuchi T,Satoh H,Asahara T,Nukui H,Naganuma H

更新日期：2006-02-01 00:00:00

abstract：:Because of his exceptional and pioneering contributions to the understanding and treatment of neurosurgical conditions, Walter Dandy is considered to be one of the founders of both neurosurgery and neuroradiology. In the field of hydrocephalus, Dandy developed revolutionary research models, imaging modalities, and ope...

journal_title：Journal of neurosurgery

authors： Blitz AM,Ahmed AK,Rigamonti D

更新日期：2018-10-01 00:00:00

abstract：:The case of a 30-year-old woman with Chiari I malformation and a cervicothoracic syrinx is presented. The patient was followed clinically over a 2 1/2-year period. Spontaneous and complete resolution of the syrinx, as documented by serial magnetic resonance studies, was accompanied by only a minimal change in objectiv...

journal_title：Journal of neurosurgery

authors： Jack CR Jr,Kokmen E,Onofrio BM

更新日期：1991-02-01 00:00:00

abstract：OBJECT:The factors that contribute to periprocedural complications following cranioplasty, including patient-specific and surgery-specific factors, need to be thoroughly assessed. The aim of this study was to evaluate risk factors that predispose patients to an increased risk of cranioplasty complications and death. M...

journal_title：Journal of neurosurgery

authors： Zanaty M,Chalouhi N,Starke RM,Clark SW,Bovenzi CD,Saigh M,Schwartz E,Kunkel ES,Efthimiadis-Budike AS,Jabbour P,Dalyai R,Rosenwasser RH,Tjoumakaris SI

更新日期：2015-07-01 00:00:00

abstract：:The metabolic rate was determined in the rat brain during the immediate concussive response to standardized impact accelerations of 7 and 9 m/sec velocity. In one series, the metabolic state was determined in freeze-clamped cortical and brain-stem tissue 20 seconds after the impact. The metabolic rate was calculated f...

journal_title：Journal of neurosurgery

authors： Nilsson B,Nordström CH

更新日期：1977-08-01 00:00:00

abstract：:The authors describe the case of a 32-year-old woman known to have Russell-Silver syndrome who presented with repeated aneurysmal subarachnoid hemorrhage. Multiple intracranial aneurysms and advanced peripheral vascular disease were demonstrated. The authors postulate a link between these vascular features and the pat...

journal_title：Journal of neurosurgery

authors： Pülhorn H,Pesic-Smith J,Cowley P,Murphy M

更新日期：2015-08-01 00:00:00