Stereotaxic implantation of dispersed cell suspensions into brain. A systematic appraisal of cell placement and survival.

Abstract:

:The application of several recent advances in cell biology, brain implantation, and cell-mediated tumor immunotherapy requires successful and reproducible placement of viable cell suspensions into brain. Stereotaxic implantation is being used to inject cytotoxic lymphocytes into gliomas and to replace dopaminergic cells in parkinsonian models. Systematic assessment of the factors that influence success in implantation of cell suspensions into solid tissues is needed. A model was developed for investigation of stereotaxic implantation using radiolabeled rat lymphokine-activated killer (LAK) cells. Anesthetized rats received microliter injections of cell suspension into the right caudate nucleus. The injection volume, cell concentration, infusion rate, and needle size were varied systematically. The animals were sacrificed 1 hour after injection; the brain was removed and sectioned, and the radioactivity was counted. Three aliquots of the suspension were injected into counting tubes for control analysis. Recovery of radioactivity was expressed as the percent of mean counts per minute (cpm) in the right frontal lobe/mean cpm in the three control tubes. To assess the viability of implanted cells, the right frontal region was mechanically dissociated in media and centrifuged, and the pellet and supernatant were counted. By using small needles and slow infusion of volumes of 10 microliters or less, 85% to 90% of the radioactivity was recovered in the caudate nucleus. At least half of the implanted cells were viable. Consistent, accurate implantation of dispersed cells into brain over a range of volumes, cell concentrations, infusion rates, and needle sizes was achieved.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Plunkett RJ,Weber RJ,Oldfield EH

doi

10.3171/jns.1988.69.2.0228

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

228-33

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

69

pub_type

杂志文章
  • Deep brain stimulation in movement disorders: stereotactic coregistration of two-dimensional electrical field modeling and magnetic resonance imaging.

    abstract:OBJECT:Adjusting electrical parameters used in deep brain stimulation (DBS) for dystonia remains time consuming and is currently based on clinical observation alone. The goal of this study was to visualize electrical parameters around the electrode, to correlate these parameters with the anatomy of the globus pallidus ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.6.0949

    authors: Hemm S,Mennessier G,Vayssiere N,Cif L,El Fertit H,Coubes P

    更新日期:2005-12-01 00:00:00

  • The use of simulation in neurosurgical education and training. A systematic review.

    abstract:OBJECT:There is increasing evidence that simulation provides high-quality, time-effective training in an era of resident duty-hour restrictions. Simulation may also permit trainees to acquire key skills in a safe environment, important in a specialty such as neurosurgery, where technical error can result in devastating...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.3171/2014.5.JNS131766

    authors: Kirkman MA,Ahmed M,Albert AF,Wilson MH,Nandi D,Sevdalis N

    更新日期:2014-08-01 00:00:00

  • Neurocognitive function before and after surgery for insular gliomas.

    abstract:OBJECT:Insular gliomas can be resected with acceptable rates of neurological morbidity, but little is known with regard to impairment of higher-order neurocognitive functions. The frequency and functional impact of neurocognitive deficits in patients with gliomas has until recently been underappreciated. The authors th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.8.JNS11488

    authors: Wu AS,Witgert ME,Lang FF,Xiao L,Bekele BN,Meyers CA,Ferson D,Wefel JS

    更新日期:2011-12-01 00:00:00

  • Percutaneous flexible bipolar epidural neuroelectrode for spinal cord stimulation. Technical note.

    abstract::This article describes a new flexible bipolar neuroelectrode which is inserted percutaneously into the epidural space for segmental spinal cord stimulation. This electrode was used in experiments with dogs and monkeys for recording cortical somatosensory evoked potentials in order to identify intraoperative spinal cor...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1317

    authors: Kaschner AG,Sandmann W,Larkamp H

    更新日期:1984-06-01 00:00:00

  • Transcranial electrical stimulation through screw electrodes for intraoperative monitoring of motor evoked potentials. Technical note.

    abstract::The feasibility of high-frequency transcranial electrical stimulation (TES) through screw electrodes placed in the skull was investigated for use in intraoperative monitoring of the motor pathways in patients who are in a state of general anesthesia during cerebral and spinal operations. Motor evoked potentials (MEPs)...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2004.100.1.0155

    authors: Watanabe K,Watanabe T,Takahashi A,Saito N,Hirato M,Sasaki T

    更新日期:2004-01-01 00:00:00

  • Treatment of neoplastic epidural cord compression by vertebral body resection and stabilization.

    abstract::The results of treatment of neoplastic spinal cord compression by vertebral body resection and immediate stabilization in 101 consecutive patients over a 5-year period have been analyzed. Sites of primary cancer included the lung (25 patients), kidney (15 patients), breast (14 patients), connective tissue (12 patients...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.5.0676

    authors: Sundaresan N,Galicich JH,Lane JM,Bains MS,McCormack P

    更新日期:1985-11-01 00:00:00

  • Magnetic resonance imaging techniques for visualization of the subthalamic nucleus.

    abstract::The authors reviewed 70 publications on MR imaging-based targeting techniques for identifying the subthalamic nucleus (STN) for deep brain stimulation in patients with Parkinson disease. Of these 70 publications, 33 presented quantitatively validated results. There is still no consensus on which targeting technique ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2011.6.JNS101571

    authors: Brunenberg EJ,Platel B,Hofman PA,Ter Haar Romeny BM,Visser-Vandewalle V

    更新日期:2011-11-01 00:00:00

  • Post-craniotomy wound infection caused by Pseudallescheria boydii. Case report.

    abstract::The authors describe the first reported case of post-craniotomy wound infection due to Pseudallescheria boydii. The patient was a 24-year-old man who sustained a direct blunt injury to the calvaria, resulting in a large subdural hematoma that was surgically evacuated. Subsequently, the surgical wound became infected w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.1.0153

    authors: Lazarus HS,Myers JP,Brocker RJ

    更新日期:1986-01-01 00:00:00

  • Randomized controlled trials in neurosurgery: an observational analysis of trial discontinuation and publication outcome.

    abstract::OBJECTIVE This study aimed to determine the trial discontinuation and publication rate of randomized controlled trials (RCTs) in neurosurgery. METHODS Trials registered from 2000 to 2012 were identified on the website clinicaltrials.gov using a range of key words related to neurosurgery. Any trials that were actively ...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章

    doi:10.3171/2016.8.JNS16765

    authors: Jamjoom AAB,Gane AB,Demetriades AK

    更新日期:2017-10-01 00:00:00

  • Anomalous rib presenting as cervical myelopathy: a previously unreported variant of Klippel-Feil syndrome. Case report.

    abstract::A patient is reported with an anomalous rib that caused compression of the cervical spinal cord and presented with cervical myelopathy. This appears to be the first reported instance of this particular anomaly. The clinicoanatomical aspects of this case are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.3.0465

    authors: Rock JP,Spickler EM

    更新日期:1991-09-01 00:00:00

  • Venous ischemia caused by dural arteriovenous malformation. Case report.

    abstract::A case is presented of tentorial dural arteriovenous malformation (AVM) associated with visual hallucinations and quadrant hemianopsia. Computerized tomography (CT) and magnetic resonance imaging showed an ischemic region, mainly affecting the white matter of the right occipital lobe, that was defined as an area of in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.80.3.0552

    authors: Kurata A,Miyasaka Y,Yoshida T,Kunii M,Yada K,Kan S

    更新日期:1994-03-01 00:00:00

  • Comparison of CT-guided and stereotaxic cranial diagnostic needle biopsies.

    abstract::Needle biopsy of the brain utilizing computerized tomography (CT) scan data is an accepted diagnostic technique that has been performed both with and without the aid of stereotaxic frames. Experience with both techniques has resulted in a specific procedure for CT-guided free-hand biopsy which is performed in the CT s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.3.0341

    authors: Goldstein S,Gumerlock MK,Neuwelt EA

    更新日期:1987-09-01 00:00:00

  • Extent of resection and the long-term durability of vestibular schwannoma surgery.

    abstract:OBJECT:With limited studies available, the correlation between the extent of resection and tumor recurrence in vestibular schwannomas (VSs) has not been definitively established. In this prospective study, the authors evaluated 772 patients who underwent microsurgical resection of VSs to analyze the association between...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.11.JNS10257

    authors: Sughrue ME,Kaur R,Rutkowski MJ,Kane AJ,Kaur G,Yang I,Pitts LH,Parsa AT

    更新日期:2011-05-01 00:00:00

  • Endoscope-assisted retrosigmoid infralabyrinthine approach to jugular foramen tumors.

    abstract:OBJECTIVE:Removal of jugular foramen (JF) tumors usually requires extensive skull base approaches and is frequently associated with postoperative morbidities such as lower cranial nerve injury. The endoscope-assisted retrosigmoid infralabyrinthine approach is a relatively new approach to tumors extending into the bony ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.3.JNS142904

    authors: Samii M,Alimohamadi M,Gerganov V

    更新日期:2016-04-01 00:00:00

  • Development of neurosurgery in Greece: past, present, and future.

    abstract::In this study the authors examine the historical tradition as well as current features of neurosurgery in Greece and compare the available data with international standards. In particular, they describe the organizational structure of neurosurgery with reference to manpower, unit distribution, training, and qualificat...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/jns.1998.88.4.0782

    authors: Stranjalis G,Singounas E

    更新日期:1998-04-01 00:00:00

  • Posterior ventricular catheter burr-hole localizer. Technical note.

    abstract::Proper ventricular catheter placements are associated with improved shunt performance. When placing ventricular catheters via the posterior approach, the surgeon must determine an optimum trajectory and then pass a catheter along that trajectory. The incidence of optimal posterior catheter placements is increased by u...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.89.1.0157

    authors: Garell PC,Mirsky R,Noh MD,Loftus CM,Hitchon PW,Grady MS,Dacey RG,Howard MA 3rd

    更新日期:1998-07-01 00:00:00

  • The neuroprotective pharmacology of methylprednisolone.

    abstract::A 24-hour intensive intravenous dosing regimen with the glucocorticoid steroid methylprednisolone has recently been shown to be effective in enhancing neurological recovery in spinal cord-injured patients when initiated within 8 hours after injury. The state of knowledge concerning the neuroprotective pharmacology of ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1992.76.1.0013

    authors: Hall ED

    更新日期:1992-01-01 00:00:00

  • Symptomatic intrasellar hemangioblastoma in a child treated with subtotal resection and adjuvant radiosurgery. Case report.

    abstract::The first documented case of a symptomatic intrasellar hemangioblastoma is described, occurring in an 11-year-old girl with stigmata of von Hippel-Lindau disease who presented with headaches, progressive bitemporal hemianopsia, and adenohypophysial dysfunction. A subtotal resection of the lesion was achieved with two ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.84.6.1046

    authors: Sawin PD,Follett KA,Wen BC,Laws ER Jr

    更新日期:1996-06-01 00:00:00

  • Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.

    abstract::The treatment of primary central nervous system lymphoma with chemotherapy prior to whole-brain radiation therapy (WBRT) has improved outcome considerably in this previously fatal disease. Complete or partial responses to intravenous methotrexate (3.5 gm/sq m with leucovorin rescue every 3 weeks for two to four cycles...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.2.0188

    authors: Glass J,Gruber ML,Cher L,Hochberg FH

    更新日期:1994-08-01 00:00:00

  • Pathogenesis of Chiari malformation: a morphometric study of the posterior cranial fossa.

    abstract::To investigate overcrowding in the posterior cranial fossa as the pathogenesis of adult-type Chiari malformation, the authors studied the morphology of the brainstem and cerebellum within the posterior cranial fossa (neural structures consisting of the midbrain, pons, cerebellum, and medulla oblongata) as well as the ...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.1997.86.1.0040

    authors: Nishikawa M,Sakamoto H,Hakuba A,Nakanishi N,Inoue Y

    更新日期:1997-01-01 00:00:00

  • A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. Part 1: Clinical and radiological findings.

    abstract::The authors have developed a method to induce chronic cerebral vasospasm after subarachnoid hemorrhage (SAH) in monkeys. With microsurgical techniques, 33 monkeys had a frontotemporal craniectomy and unilateral opening of the subarachnoid cisterns. Cerebrospinal fluid was drained and a fresh hematoma, obtained from an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1167

    authors: Espinosa F,Weir B,Overton T,Castor W,Grace M,Boisvert D

    更新日期:1984-06-01 00:00:00

  • Safety and accuracy of incisionless transcranial MR-guided focused ultrasound functional neurosurgery: single-center experience with 253 targets in 180 treatments.

    abstract::OBJECTIVESince the first clinical application of the incisionless magnetic resonance-guided focused ultrasound (MRgFUS) technology only small series of patients have been reported, and thus only extrapolations of the procedure-related risks could be offered. In this study, the authors analyze side-effects and targetin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.12.JNS172054

    authors: Gallay MN,Moser D,Jeanmonod D

    更新日期:2018-05-01 00:00:00

  • Proximal occlusion of the anterior cerebral artery for anterior communicating aneurysm.

    abstract::Results of proximal anterior cerebral artery occlusion are described in 68 patients with anterior communicating artery aneurysms. The procedure is found useful in the treatment of these aneurysms because of its technical simplicity and the low rates of mortality and morbidity achieved. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.43.4.0426

    authors: Hockley AD

    更新日期:1975-10-01 00:00:00

  • Dysembryoplastic neuroepithelial tumor of the cerebellum and brainstem. Case report.

    abstract::The authors present a case in which dysembryoplastic neuroepithelial tumors (DNETs) occurred in the cerebellum and brainstem of a 44-year-old woman. A magnetic resonance image of the brain revealed multiple cystic lesions in the right cerebellar hemisphere, vermis, tonsil, and brainstem. Partial removal of the tumors ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.3.0487

    authors: Fujimoto K,Ohnishi H,Tsujimoto M,Hoshida T,Nakazato Y

    更新日期:2000-09-01 00:00:00

  • Speech changes induced by deep brain stimulation of the subthalamic nucleus in Parkinson disease: involvement of the dentatorubrothalamic tract.

    abstract::OBJECTIVE Patients with Parkinson disease (PD) who undergo subthalamic nucleus (STN) deep brain stimulation (DBS) often develop a deterioration in speech performance, but there is no clear consensus on the specific effects seen or the mechanism involved and little description of the impact of DBS on conversational spe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.5.JNS16243

    authors: Fenoy AJ,McHenry MA,Schiess MC

    更新日期:2017-06-01 00:00:00

  • Reliability of left and right indicators in CT scanning of the head. Case report.

    abstract::A case is described in which incorrect preliminary programming of a computerized tomography (CT) machine caused transposition of the left- and right-side indicators in a CT scan, which led to craniotomy on the normal side. The possible mechanism for this is incorrect pre-scan programming of the CT scanner with respect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.2.0291

    authors: Luessenhop AJ,Schellinger D

    更新日期:1987-08-01 00:00:00

  • Correlation between magnetic resonance imaging grading and pathological grading in meningioma.

    abstract:OBJECT:This study investigated the specific preoperative MRI features of patients with intracranial meningiomas that correlate with pathological grade and provide appropriate preoperative planning. METHODS:From 2006 to 2012, 120 patients (36 men and 84 women, age range 20-89 years) with newly diagnosed symptomatic int...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.7.JNS132359

    authors: Lin BJ,Chou KN,Kao HW,Lin C,Tsai WC,Feng SW,Lee MS,Hueng DY

    更新日期:2014-11-01 00:00:00

  • The anatomy of the Berrettini branch: implications for carpal tunnel release.

    abstract:OBJECT:Dissections were performed in 100 fresh cadaver palms to determine the frequency with which superficial palmar communication between the median and ulnar nerves occurs and to what extent it might incur iatrogenic injury during endoscopic carpal tunnel release. METHODS:Superficial palmar communication between th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.6.1027

    authors: Stancić MF,Mićović V,Potocnjak M

    更新日期:1999-12-01 00:00:00

  • Delayed complication after Gamma Knife surgery for mesial temporal lobe epilepsy.

    abstract:OBJECT:Despite the controversy over the clinical significance of Gamma Knife surgery (GKS) for refractory mesial temporal lobe epilepsy (MTLE), the modality has attracted attention because it is less invasive than resection. The authors report long-term outcomes for 7 patients, focusing in particular on the long-term c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.2.JNS111296

    authors: Usami K,Kawai K,Koga T,Shin M,Kurita H,Suzuki I,Saito N

    更新日期:2012-06-01 00:00:00

  • Endosphenoidal coil for intraoperative magnetic resonance imaging of the pituitary gland during transsphenoidal surgery.

    abstract::OBJECTIVE Pituitary MR imaging fails to detect over 50% of microadenomas in Cushing's disease and nearly 80% of cases of dural microinvasion. Surface coils can generate exceptionally high-resolution images of the immediately adjacent tissues. To improve imaging of the pituitary gland, a receive-only surface coil that ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.11.JNS151465

    authors: Chittiboina P,Talagala SL,Merkle H,Sarlls JE,Montgomery BK,Piazza MG,Scott G,Ray-Chaudhury A,Lonser RR,Oldfield EH,Koretsky AP,Butman JA

    更新日期:2016-12-01 00:00:00