Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.

Abstract:

:The treatment of primary central nervous system lymphoma with chemotherapy prior to whole-brain radiation therapy (WBRT) has improved outcome considerably in this previously fatal disease. Complete or partial responses to intravenous methotrexate (3.5 gm/sq m with leucovorin rescue every 3 weeks for two to four cycles) were seen in 12 of 13 patients originally treated. A total of 25 patients (including the original 13) have now been treated with one to six cycles of methotrexate every 10 to 21 days prior to WBRT. Twenty-two had partial or complete responses, with a median duration of response of 32 months. Median survival time was 33 months (42.5 months in those responding to therapy). Nine patients are alive and without evidence of disease 9 to 122 months following therapy. Acute and long-term toxicities were minimal. Systemic methotrexate administration prior to WBRT is well tolerated and produces long-term survival.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Glass J,Gruber ML,Cher L,Hochberg FH

doi

10.3171/jns.1994.81.2.0188

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

188-95

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

81

pub_type

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