History of neurosurgery at University of Toronto: the St. Michael's story.


:In this paper, the authors describe the history of neurosurgery at St. Michael's Hospital, University of Toronto. St. Michael's has long been regarded as one of the top teaching and research hospitals in Canada. A detailed literature review of published and unpublished works was performed to formulate a succinct but in-depth review of its development, successes, and challenges. This fascinating 125-year history serves as a reminder of the importance of their institution's origins, and the authors hope that it will be a useful guide for developing programs around the world.


J Neurosurg


Journal of neurosurgery


Alotaibi NM,Guha D,Ahuja CS,Spears J,Muller PJ,Tucker WS,Hudson AR,Macdonald RL




Has Abstract


2017-12-01 00:00:00












  • Superficial peroneal nerve syndrome: an unusual nerve entrapment. Case report.

    abstract::Lower-extremity pain and paresthesia have multiple origins. Early recognition of the symptoms of peripheral nerve entrapment leads to timely treatment and avoids the cost of unnecessary studies. The authors report on a case of superficial peroneal nerve syndrome resulting from nerve herniation through a fascial defect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yang LJ,Gala VC,McGillicuddy JE

    更新日期:2006-05-01 00:00:00

  • Development of the Wireless Instantaneous Neurotransmitter Concentration System for intraoperative neurochemical monitoring using fast-scan cyclic voltammetry.

    abstract:OBJECT:Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain stimulation (DBS) and motor cortex stimulation (MCS). Real-time monitoring of the neurochemical output of targeted regions may therefore advance functional neurosurger...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Bledsoe JM,Kimble CJ,Covey DP,Blaha CD,Agnesi F,Mohseni P,Whitlock S,Johnson DM,Horne A,Bennet KE,Lee KH,Garris PA

    更新日期:2009-10-01 00:00:00

  • Clinical and electroneurographic evaluation of sensory/motor-differentiated nerve repair in the hand.

    abstract::In 17 patients acetylcholinesterase activity was used to differentiate between sensory and motor fascicles in median and ulnar nerve repair of the hand. Eleven patients received follow-up evaluation 1 to 11 years after surgery, and at that time clinical and electroneurographic examinations were performed to evaluate t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Deutinger M,Girsch W,Burggasser G,Windisch A,Mayr N,Freilinger G

    更新日期:1993-05-01 00:00:00

  • Surgical outcomes of the minimum anterior and posterior combined transpetrosal approach for resection of retrochiasmatic craniopharyngiomas with complicated conditions.

    abstract:OBJECT:Retrochiasmatic craniopharyngiomas are surgically challenging tumors. Retrochiasmatic craniopharyngiomas with complicated conditions such as large diameter, major calcification, or significant extension to the third ventricle or posterior fossa present surgical challenges; moreover, recurrent retrochiasmatic cra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kunihiro N,Goto T,Ishibashi K,Ohata K

    更新日期:2014-01-01 00:00:00

  • Extrapyramidal disorder with pineal germinoma. Case report.

    abstract::Space-occupying lesions of the basal ganglia are a rare cause of extrapyramidal dysfunction in children. Metastatic pineal germinoma in both basal ganglia produced dystonia in a 12-year-old boy. The literature is reviewed. Extrapyramidal manifestations in the child are compared with previously reported cases of basal ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Lins MM,McDonnell DE,Aschenbrener CA,Cancilla PA

    更新日期:1978-01-01 00:00:00

  • Longitudinal survey of cranial case log entries during neurological surgery residency training.

    abstract::OBJECTIVEThe purpose of this study was to analyze national trends in adult cranial cases performed by neurological surgery residents as logged into the Accreditation Council for Graduate Medical Education (ACGME) system.METHODSThe ACGME resident case logs were retrospectively reviewed for the years 2009-2017. In these...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Agarwal N,White MD,Cohen J,Lunsford LD,Hamilton DK

    更新日期:2018-07-01 00:00:00

  • Assessing variability in surgical decision making among attending neurosurgeons at an academic center.

    abstract:OBJECTIVE:Although it is known that intersurgeon variability in offering elective surgery can have major consequences for patient morbidity and healthcare spending, data addressing variability within neurosurgery are scarce. The authors performed a prospective peer review study of randomly selected neurosurgery cases i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ramayya AG,Chen HI,Marcotte PJ,Brem S,Zager EL,Osiemo B,Piazza M,Sharma N,McClintock SD,Schuster JM,Ali ZS,Connolly P,Heuer GG,Grady MS,Kung DK,Ozturk AK,O'Rourke DM,Malhotra NR

    更新日期:2019-05-31 00:00:00

  • Expanded endonasal approach: vidian canal as a landmark to the petrous internal carotid artery.

    abstract::The purpose of this study was to describe the technique used to safely identify the petrous carotid artery during expanded endonasal approaches to the skull base. A series of 20 cadaveric studies was undertaken to isolate the vidian artery and nerve and to use them as landmarks to the petrous internal carotid artery (...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kassam AB,Vescan AD,Carrau RL,Prevedello DM,Gardner P,Mintz AH,Snyderman CH,Rhoton AL

    更新日期:2008-01-01 00:00:00

  • Multilevel anterior cervical fusion using skull bone grafts. Case report.

    abstract::The successful use of autogenous skull bone grafts for a C3-7 anterior cervical fusion is reported and compared with results using other bone grafts. A 51-year-old man with C4-7 anterior cord compression due to spurs and ossified posterior longitudinal ligaments developed progressive tetraparesis following a minor hea...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tanaka T,Ninchoji T,Uemura K,Ryu H,Sugiura M,Ohishi H,Tomita M,Takehara S,Yamamoto T

    更新日期:1992-02-01 00:00:00

  • Vision of the future: initial experience with intraoperative real-time high-resolution dynamic infrared imaging. Technical note.

    abstract::High-resolution dynamic infrared (DIR) imaging provides intraoperative real-time physiological, anatomical, and pathological information; however, DIR imaging has rarely been used in neurosurgical patients. The authors report on their initial experience with intraoperative DIR imaging in 30 such patients. A novel, lon...

    journal_title:Journal of neurosurgery



    authors: Ecker RD,Goerss SJ,Meyer FB,Cohen-Gadol AA,Britton JW,Levine JA

    更新日期:2002-12-01 00:00:00

  • Delayed radiation necrosis of the brain.

    abstract::The cases of six patients are presented to delineate the clinical profile of delayed radiation necrosis of the brain. In five the diagnosis was verified histologically. Symptoms most often begin 9 months to 2 years after radiotherapy. Progressive visual impairment and dementia are common following perisellar irradiati...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Martins AN,Johnston JS,Henry JM,Stoffel TJ,Di Chiro G

    更新日期:1977-09-01 00:00:00

  • Prospective study of 100 lumbosacral discectomies.

    abstract::A prospective study of 100 patients undergoing discectomy was carried out. The neurological findings were documented preoperatively and at 1 month and 1 year postoperatively. The clinical and radiological data were analyzed with respect to significant associations. There were no complications. At a minimum of 1 year p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Weir BK

    更新日期:1979-03-01 00:00:00

  • Phase II study of nimustine, carboplatin, vincristine, and interferon-beta with radiotherapy for glioblastoma multiforme: experience of the Kyoto Neuro-Oncology Group.

    abstract:OBJECT:This Phase II study was performed to determine the safety, tolerability, and efficacy of combining nimustine (ACNU)-carboplatin-vincristine-Interferon-beta (IFNbeta) chemotherapy. METHODS:Ninety-seven patients with Karnofsky Performance Scale scores of 50 or greater were enrolled in the study. Nimustine (60 mg/...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Aoki T,Takahashi JA,Ueba T,Oya N,Hiraoka M,Matsui K,Fukui T,Nakashima Y,Ishikawa M,Hashimoto N

    更新日期:2006-09-01 00:00:00

  • Modified stereotactic insertion of the Ommaya reservoir. Technical note.

    abstract::Ommaya reservoirs are used primarily for the repeated injection of intrathecal chemotherapy for leptomeningeal metastasis from hematopoietic and solid malignancies. Insertion of this device in a relatively large nondisplaced ventricle is not a difficult task, but challenges arise when the ventricle is small and/or dis...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Al-Anazi A,Bernstein M

    更新日期:2000-06-01 00:00:00

  • Risks associated with preoperative anemia and perioperative blood transfusion in open surgery for intracranial aneurysms.

    abstract:OBJECT:Preoperative anemia may be treated with a blood transfusion. Both are associated with adverse outcomes in various surgical procedures, but this has not been clearly elucidated in surgery for cerebral aneurysms. In this study the authors assessed the association of preoperative anemia and perioperative blood tran...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究


    authors: Seicean A,Alan N,Seicean S,Neuhauser D,Selman WR,Bambakidis NC

    更新日期:2015-07-01 00:00:00

  • Evaluation of anorectal function in patients with tethered cord syndrome: saline enema test and fecoflowmetry.

    abstract:OBJECT:Disturbance in anorectal function is a major factor restricting the activities of daily living in patients with spinal cord disorders. To detect changes in anorectal motilities due to a tethered spinal cord, anorectal functions were evaluated using a saline enema test and fecoflowmetry before and after patients ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kayaba H,Hebiguchi T,Itoh Y,Yoshino H,Mizuno M,Morii M,Adachi T,Chihara J,Kato T

    更新日期:2003-04-01 00:00:00

  • Cysts of the atlantoaxial joint: excellent long-term outcome after posterolateral surgical decompression. Report of two cases.

    abstract::Articular cysts of the atlantoaxial joint are infrequently described and probably an underreported cause of upper cervical spinal cord compression. The authors report on two patients with cysts located posteriorly of the dens in whom a C-1 and partial C-2 hemilaminectomy with subtotal resection of the cyst provided ad...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zorzon M,Skrap M,Diodato S,Nasuelli D,Lucci B

    更新日期:2001-07-01 00:00:00

  • Pineal cyst resection in the absence of ventriculomegaly or Parinaud's syndrome: clinical outcomes and implications for patient selection.

    abstract:OBJECT:Surgical indications for patients with pineal cysts are controversial. While the majority of patients harboring a pineal cyst require no treatment, surgery is a well-accepted option for a subset of those patients with secondary hydrocephalus or Parinaud's syndrome. The majority of pineal cysts are identified inc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kalani MY,Wilson DA,Koechlin NO,Abuhusain HJ,Dlouhy BJ,Gunawardena MP,Nozue-Okada K,Teo C

    更新日期:2015-08-01 00:00:00

  • Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system.

    abstract::The protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administration of the PKC-activ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Couldwell WT,Antel JP,Apuzzo ML,Yong VW

    更新日期:1990-10-01 00:00:00

  • A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor.

    abstract::In order to assess the clinical and biological effects of glucocorticoids in the therapy of epidural spinal cord compression, the T8-10 epidural space of 50 rats was implanted with Walker 256 tumor. The rats were studied 10 to 20 days later when they became paraparetic. The regional blood-spinal cord transport constan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Delattre JY,Arbit E,Thaler HT,Rosenblum MK,Posner JB

    更新日期:1989-06-01 00:00:00

  • Pure sylvian fissure arteriovenous malformations.

    abstract:OBJECT:Pure sylvian fissure arteriovenous malformations (AVMs) are vascular malformations confined to the sylvian fissure without parenchymal involvement. Because the branches of the middle cerebral artery are arteries of passage and the margins between the AVM and the insula cortex may be ill defined, many surgeons re...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zimmerman G,Lewis AI,Tew JM Jr

    更新日期:2000-01-01 00:00:00

  • Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: variations of the same theme.

    abstract:OBJECT:Ascites and abdominal pseudocysts are two complications that can occur following placement of a ventriculoperitoneal (VP) shunt. Although various factors have been implicated, the exact pathogenesis of the two conditions remains elusive. To the authors' knowledge, there are no studies in which these two obviousl...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kariyattil R,Steinbok P,Singhal A,Cochrane DD

    更新日期:2007-05-01 00:00:00

  • The course of chronic subdural hematomas after burr-hole craniostomy and closed-system drainage.

    abstract::A consecutive series of 32 adult patients with chronic subdural hematoma was studied in respect to postoperative cerebral reexpansion (reduction in diameter of the subdural space) after burr-hole craniostomy and closed-system drainage. Patients with high subdural pressure showed the most rapid brain expansion and clin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Markwalder TM,Steinsiepe KF,Rohner M,Reichenbach W,Markwalder H

    更新日期:1981-09-01 00:00:00

  • Medical school and residency influence on choice of an academic career and academic productivity among neurosurgery faculty in the United States. Clinical article.

    abstract:OBJECT:Factors determining choice of an academic career in neurological surgery are unclear. This study seeks to evaluate the graduates of medical schools and US residency programs to determine those programs that produce a high number of graduates remaining within academic programs and the contribution of these gradua...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Campbell PG,Awe OO,Maltenfort MG,Moshfeghi DM,Leng T,Moshfeghi AA,Ratliff JK

    更新日期:2011-08-01 00:00:00

  • Systemic gamma-interferon therapy for recurrent gliomas.

    abstract::Recombinant gamma-interferon (2 mg/sq m) was administered intravenously twice weekly in 8-week courses to 14 patients with recurrent gliomas. Computerized tomography (CT) evidence of response was seen in only one patient, and stabilization for 12 to 86 weeks was recorded in three. This was a disappointing result, part...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Mahaley MS Jr,Bertsch L,Cush S,Gillespie GY

    更新日期:1988-12-01 00:00:00

  • A physical simulator for endoscopic endonasal drilling techniques: technical note.

    abstract::In this paper, the authors present a physical model developed to teach surgeons the requisite drilling techniques when using an endoscopic endonasal approach (EEA) to the skull base. EEA is increasingly used for treating pathologies of the ventral and ventrolateral cranial base. Endonasal drilling is a unique skill in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tai BL,Wang AC,Joseph JR,Wang PI,Sullivan SE,McKean EL,Shih AJ,Rooney DM

    更新日期:2016-03-01 00:00:00

  • Titanium mesh cages for cervical spine stabilization after corpectomy: a clinical and radiological study.

    abstract:OBJECT:Reconstruction after anterior cervical decompression has involved the use of tricortical iliac crest bone or fibular strut grafts, but has been associated with significant morbidity. In this study the authors evaluated the efficacy of titanium mesh cages (TMCs) for stability and fusion following anterior cervica...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Narotam PK,Pauley SM,McGinn GJ

    更新日期:2003-09-01 00:00:00

  • Carbamazepine in the treatment of the flashing pain syndrome.

    abstract::Five patients were seen who described similar rapid shot-like pains that we have called "flashing pain syndrome" and whose pain was relieved by carbamazepine. The pathology of these conditions is not uniform, but the clinical description appears to be specific for an unpleasant condition that will respond dramatically...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Dunsker SB,Mayfield FH

    更新日期:1976-07-01 00:00:00

  • Cerebrovascular effects of hypocapnia during adenosine-induced arterial hypotension.

    abstract::Profound arterial hypotension is a commonly used adjunct in surgery for aneurysms and arteriovenous malformations. Hyperventilation with hypocapnia is also used in these patients to increase brain slackness. Both measures reduce cerebral blood flow (CBF). Of concern is whether CBF is reduced below ischemic thresholds ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Boarini DJ,Kassell NF,Sprowell JA,Olin JJ,Coester HC

    更新日期:1985-12-01 00:00:00

  • Vestibular schwannoma management. Part I. Failed microsurgery and the role of delayed stereotactic radiosurgery.

    abstract:OBJECT:The purpose of this study was to analyze patient outcomes and to define the role of radiosurgery in patients who have undergone prior microsurgical resection of their vestibular schwannoma. METHODS:The authors evaluated the pre- and postoperative clinical and neuroimaging characteristics of 76 consecutive patie...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pollock BE,Lunsford LD,Flickinger JC,Clyde BL,Kondziolka D

    更新日期:1998-12-01 00:00:00