Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.

Abstract:

OBJECT:Endothelial tight junction (TJ) expression is mostly absent in cerebral cavernous malformations (CMs), which causes increased perilesional erythrocyte and fluid oozing. However, in a subset of CM lesions, foci of preserved TJ staining are observed along endothelial cell contacts. The clinical relevance of this finding is unclear. This study investigates the relevance of the focal TJ protein expression and its association with CM bleeding propensity. METHODS:Immunohistochemical staining for the TJ proteins claudin-5, occludin, and ZO-1 was performed on 32 CM specimens that were resected during 2008-2010. The patients were allocated to 2 groups according to TJ protein expression, and the clinical and radiological parameters of aggressiveness were analyzed and compared. RESULTS Complete absence of TJ expression was identified in 20 specimens, and focal TJ protein expression in 12. CMs without TJ immunoreactivity were significantly larger (p = 0.022) and had a significantly greater propensity for development of frank hematomas (p = 0.028) and perilesional edema (p = 0.013). Symptom severity, multiplicity, developmental venous anomaly (DVA) presence, and CM location did not show a significant difference depending on TJ expression. CONCLUSIONS:In a univariate analysis the authors observed significantly less propensity for frank hematomas and perilesional edema as well as smaller size in CM lesions with focal TJ expression compared with CMs without TJ expression. The observed difference in TJ protein expression might be the reason for differences in bleeding propensity of the CM lesions. Although this finding cannot be used in predictive manner at this time, it is a basis for further multivariate analyses of possible CM biological predictors.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Jakimovski D,Schneider H,Frei K,Kennes LN,Bertalanffy H

doi

10.3171/2014.6.JNS132775

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

613-20

issue

3

eissn

0022-3085

issn

1933-0693

journal_volume

121

pub_type

杂志文章
  • Transcranial approach to the orbit: microsurgical anatomy.

    abstract::An anatomical study of three microsurgical intraorbital routes to the optic nerve and orbital apex, which can be reached through a fronto-orbital craniotomy, was conducted on cadaver specimens. The structures that could be exposed via the medial, central, or lateral approaches directed through the orbital roof were de...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.1.0078

    authors: Natori Y,Rhoton AL Jr

    更新日期:1994-07-01 00:00:00

  • Parasellar epidermoid tumor presenting as painful ophthalmoplegia.

    abstract::In 1964, a 51-year-old man experienced a right abducens nerve palsy, which resolved spontaneously. In 1978, he developed painful ophthalmoplegia on the right with paresis of the right oculomotor and trigeminal nerves. Neuroradiographic evaluation was reported unremarkable, and the painful ophthalmoplegia was attribute...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.54.1.0113

    authors: Kline LB,Galbraith JG

    更新日期:1981-01-01 00:00:00

  • Gamma knife surgery for choroidal neovascularization in age-related macular degeneration. Technical note.

    abstract::The authors conducted a study to determine a way of overcoming the poor-quality demonstration of choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) on conventional magnetic resonance (MR) imaging studies. The poor MR imaging demonstration of CNV in patients with AMD makes the use...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.s_supplement.0200

    authors: Hayashi M,Chernov M,Usukura M,Abe K,Ono Y,Izawa M,Hori S,Hori T,Takakura K

    更新日期:2005-01-01 00:00:00

  • Neurological and pathological effects of second lumbar spondylectomy and spinal column shortening in the dog.

    abstract::The second lumbar vertebra was surgically removed from 10 dogs, and the shortened vertebral column was stabilized by internal fixation with two types of plastic plates. Shortening of the spinal column was usually not associated with detectable loss of function or neurological deficit. Histological lesions, however, in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.42.1.0047

    authors: Yturraspe DJ,Lumb WV,Young S,Gorman HA

    更新日期:1975-01-01 00:00:00

  • MR imaging of CSF pulsatory flow and its relation to intracranial pressure.

    abstract::In a retrospective study of magnetic resonance (MR) images obtained in 289 neurosurgical patients, loss of signal intensity (signal-void phenomenon, SVP) of the cerebrospinal fluid (CSF) in the mesencephalic aqueduct was observed in 77 patients. This SVP was noted in the MR studies of 12 of 14 patients with communicat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.69.5.0675

    authors: Ohara S,Nagai H,Matsumoto T,Banno T

    更新日期:1988-11-01 00:00:00

  • Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies.

    abstract::The authors describe the clinical behavior of eight patients with cerebral astrocytomas, in whom computerized tomography (CT) or magnetic resonance (MR) imaging of the brain was characterized by diffuse bilateral cerebral hemisphere tissue density abnormalities and minimal focal mass effect. Five patients were newly d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.6.0817

    authors: Rogers LR,Weinstein MA,Estes ML,Cairncross JG,Strachan T

    更新日期:1994-12-01 00:00:00

  • Unilateral septal technique for transsphenoidal microsurgical approach to the sella turcica. Technical note.

    abstract::A modification of the transseptal, transsphenoidal appraoch to the sella turcica is described; it consists of a unilateral separation of the nasal mucosa from the nasal septum. Experience with the technique in 215 cases has indicated that it is a useful, practical appraoch. The advantages are that the septum is spared...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.49.1.0138

    authors: Tindall GT,Collins WF Jr,Kirchner JA

    更新日期:1978-07-01 00:00:00

  • Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia.

    abstract:OBJECT:Exogenous progesterone has been shown to reduce brain edema and ischemia-induced cell damage and to improve physiological and neurological function during the early stage of focal cerebral ischemia. In the present study, the authors assessed the neuroprotective potential of progesterone during the late stage of ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.92.5.0848

    authors: Kumon Y,Kim SC,Tompkins P,Stevens A,Sakaki S,Loftus CM

    更新日期:2000-05-01 00:00:00

  • Relationship of intraoperative electrophysiological criteria to outcome after selective functional posterior rhizotomy.

    abstract::At British Columbia's Children's Hospital, the criteria used in selective functional posterior rhizotomy (SFPR) evolved in three distinct phases. In Phase 1 the electrophysiological criteria for abnormality included a low threshold to a single stimulation, a sustained response to 50-Hz stimulation, and spread outside ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.1.0018

    authors: Steinbok P,Gustavsson B,Kestle JR,Reiner A,Cochrane DD

    更新日期:1995-07-01 00:00:00

  • Cerebral revascularization and carotid artery resection at the skull base for treatment of advanced head and neck malignancies.

    abstract:OBJECT:Resection of cancer and the involved artery in the neck has been applied with some success, but the indications for such an aggressive approach at the skull base are less well defined. The authors therefore evaluated the outcomes of advanced skull base malignancies in patients who were treated with bypass and re...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.9.JNS12332

    authors: Kalani MY,Kalb S,Martirosyan NL,Lettieri SC,Spetzler RF,Porter RW,Feiz-Erfan I

    更新日期:2013-03-01 00:00:00

  • Transcranial electrical stimulation through screw electrodes for intraoperative monitoring of motor evoked potentials. Technical note.

    abstract::The feasibility of high-frequency transcranial electrical stimulation (TES) through screw electrodes placed in the skull was investigated for use in intraoperative monitoring of the motor pathways in patients who are in a state of general anesthesia during cerebral and spinal operations. Motor evoked potentials (MEPs)...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2004.100.1.0155

    authors: Watanabe K,Watanabe T,Takahashi A,Saito N,Hirato M,Sasaki T

    更新日期:2004-01-01 00:00:00

  • The pineal gland: anatomy, physiology, and clinical significance.

    abstract::Since the discovery of melatonin approximately 25 years ago, there has been intense study regarding the details of the structure and function of the pineal gland. This work is reviewed, with particular emphasis on those aspects of importance to human physiology and disease. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1985.63.3.0321

    authors: Erlich SS,Apuzzo ML

    更新日期:1985-09-01 00:00:00

  • Anomalies of the posterior communicating artery and their potential clinical significance.

    abstract::This study of the posterior communicating artery (PCoA) in 126 cranial cavities of adult cadavers revealed some hitherto unreported anomalies. These included: the origin of one PCoA from the ophthalmic artery inside the optic canal; the presence of three PCoA's on one side; the occurrence of two posterior cerebral art...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.3.0572

    authors: Bisaria KK

    更新日期:1984-03-01 00:00:00

  • Pituitary apoplexy associated with a triple bolus test. Case report.

    abstract::The authors report a case of pituitary apoplexy resulting in bilateral internal carotid artery occlusion, with marked depression of consciousness and hemiplegia. After transsphenoidal tumor decompression, restoration of flow in both carotid arteries was documented angiographically and the patient made an excellent cli...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.61.3.0586

    authors: Bernstein M,Hegele RA,Gentili F,Brothers M,Holgate R,Sturtridge WC,Deck J

    更新日期:1984-09-01 00:00:00

  • A vascular malformation mimicking an intracanalicular acoustic neurilemoma. Case report.

    abstract::A patient with an enhancing, completely intracanalicular mass on magnetic resonance imaging was operated on for a presumed acoustic neurilemoma, but was found at surgery to have an intracanalicular vascular malformation. This rare lesion should be distinguished from angiomatous change within an acoustic neurilemoma an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.74.3.0516

    authors: Linskey ME,Jannetta PJ,Martinez AJ

    更新日期:1991-03-01 00:00:00

  • Angiographic frequency of saccular intracranial aneurysms in patients with spontaneous cervical artery dissection.

    abstract::The pathogenesis of intracranial aneurysms and spontaneous cervical artery dissection is incompletely understood but a primary arteriopathy, possibly similar in both disorders, may be of importance. To investigate the frequency of intracranial aneurysms in patients with spontaneous cervical artery dissection, the angi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.76.1.0062

    authors: Schievink WI,Mokri B,Piepgras DG

    更新日期:1992-01-01 00:00:00

  • Multiple schwannomas: schwannomatosis or neurofibromatosis type 2?

    abstract:OBJECT:The aim of this study was to clarify the clinical outcome of schwannomatosis, a rare condition characterized by multiple nonvestibular schwannomas in the absence of meningiomas, intraspinal ependymomas, and other clinical signs of neurofibromatosis type 2 (NF2). METHODS:Nine patients with schwannomatosis treate...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.89.1.0036

    authors: Seppälä MT,Sainio MA,Haltia MJ,Kinnunen JJ,Setälä KH,Jääskeläinen JE

    更新日期:1998-07-01 00:00:00

  • Short-term preoperative treatment of macroprolactinomas by dopamine agonists.

    abstract::During a period of 3 years, 25 patients with intra- and extrasellar macroprolactinomas were pretreated with dopamine agonists for a period of 2 to 6 1/2 weeks prior to transsphenoidal microsurgical tumor resection. Dopamine agonists were administered orally to 17 patients, intramuscularly to three patients, and both o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.6.0807

    authors: Fahlbusch R,Buchfelder M,Schrell U

    更新日期:1987-12-01 00:00:00

  • Analysis of von hippel-lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity.

    abstract:OBJECT:Hemangioblastomas (HBs) occur sporadically or as a manifestation of von Hippel-Lindau (VHL) disease. In the majority of VHL-related HBs, inactivation of the VHL tumor suppressor gene (TSG), which is located on chromosome 3p25-26, is found. The VHL gene is assumed to be involved also in the development of sporadi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.4.0977

    authors: Gijtenbeek JM,Jacobs B,Sprenger SH,Eleveld MJ,van Kessel AG,Kros JM,Sciot R,van Calenbergh F,Wesseling P,Jeuken JW

    更新日期:2002-10-01 00:00:00

  • Neuronavigated percutaneous approach to the sphenopalatine ganglion.

    abstract::The sphenopalatine ganglion (SPG) has been assumed to be involved in the genesis of several types of facial pain, including Sluder's neuralgia, trigeminal neuralgia, persistent idiopathic facial pain, cluster headache, and atypical facial pain. The gold standard treatments for SPG-related pain are percutaneous procedu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.1.JNS152272

    authors: Benedetto N,Perrini P

    更新日期:2017-02-01 00:00:00

  • Indications for nonoperative treatment of spinal cord compression due to breast cancer.

    abstract::A retrospective series of 12,478 patients with breast cancer included 2467 patients with spinal metastases. Local treatment was not necessary in 688 patients. Neurological dificit did not develop in 1735 patients who underwent radiotherapy. Forty-four patients developed myelopathy due to spinal cord compression as dem...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.47.5.0653

    authors: Cobb CA 3rd,Leavens ME,Eckles N

    更新日期:1977-11-01 00:00:00

  • Propofol in the treatment of moderate and severe head injury: a randomized, prospective double-blinded pilot trial.

    abstract:OBJECT:Sedation regimens for head-injured patients are quite variable. The short-acting sedative-anesthetic agent propofol is being increasingly used in such patients, yet little is known regarding its safety and efficacy. In this multicenter double-blind trial, a titratable infusion of 2% propofol accompanied by low-d...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3171/jns.1999.90.6.1042

    authors: Kelly DF,Goodale DB,Williams J,Herr DL,Chappell ET,Rosner MJ,Jacobson J,Levy ML,Croce MA,Maniker AH,Fulda GJ,Lovett JV,Mohan O,Narayan RK

    更新日期:1999-06-01 00:00:00

  • Radiation-induced atypical meningioma with rapid growth in a 13-year-old girl. Case report.

    abstract::This case illustrates the potential growth rate of an atypical meningioma in a pediatric patient, emphasizes one of the potential risks after therapeutic radiation, and underscores the importance of clinical evaluation and follow up of the symptomatic patient after tumor resection and radiation therapy. The authors re...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2004.100.5.0488

    authors: Ware ML,Cha S,Gupta N,Perry VL

    更新日期:2004-05-01 00:00:00

  • A retrospective cohort-matched comparison of conscious sedation versus general anesthesia for supratentorial glioma resection. Clinical article.

    abstract:OBJECT:Glioma resection under conscious ("awake") sedation (CS) is used for eloquent areas of the brain to minimize postoperative neurological deficits. The objective of this study was to compare the duration of hospital stay, overall hospital cost, perioperative morbidity, and postoperative patient functional status i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.5.JNS1041

    authors: Peruzzi P,Bergese SD,Viloria A,Puente EG,Abdel-Rasoul M,Chiocca EA

    更新日期:2011-03-01 00:00:00

  • Surgical strategy for distal anterior cerebral artery aneurysms: microsurgical anatomy.

    abstract:OBJECT:Most distal anterior cerebral artery (ACA) aneurysms arise at the pericallosal-callosomarginal artery (PerA-CMA) junction, which is usually located in the A3 segment of the ACA around the genu of the corpus callosum. Aneurysms in the PerA-CMA junction are divided into two types according to their location: supra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.3.0517

    authors: Kawashima M,Matsushima T,Sasaki T

    更新日期:2003-09-01 00:00:00

  • Distribution of cerebellar tonsil position: implications for understanding Chiari malformation.

    abstract:OBJECT:Prior attempts to define normal cerebellar tonsil position have been limited by small numbers of patients precluding analysis of normal distribution by age group. The authors' objective in the present study was to analyze cerebellar tonsil location in every age range. METHODS:Two thousand four hundred patients ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.5.JNS121825

    authors: Smith BW,Strahle J,Bapuraj JR,Muraszko KM,Garton HJ,Maher CO

    更新日期:2013-09-01 00:00:00

  • Intracerebral hemorrhage after carotid endarterectomy.

    abstract::A series of 14 patients with intracerebral hemorrhage after carotid endarterectomy is reviewed. This complication occurred in 0.6% of 2362 consecutive carotid endarterectomies performed at the Mayo Clinic from 1972 through 1986. All hemorrhages occurred within the first 2 weeks after operation and were ipsilateral to ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.4.0532

    authors: Piepgras DG,Morgan MK,Sundt TM Jr,Yanagihara T,Mussman LM

    更新日期:1988-04-01 00:00:00

  • Post-craniotomy wound infection caused by Pseudallescheria boydii. Case report.

    abstract::The authors describe the first reported case of post-craniotomy wound infection due to Pseudallescheria boydii. The patient was a 24-year-old man who sustained a direct blunt injury to the calvaria, resulting in a large subdural hematoma that was surgically evacuated. Subsequently, the surgical wound became infected w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.1.0153

    authors: Lazarus HS,Myers JP,Brocker RJ

    更新日期:1986-01-01 00:00:00

  • A bacteriological study of craniocerebral missile wounds from Vietnam.

    abstract::Bacteriological studies were performed on 45 craniocerebral missile wounds incurred in Vietnam within 2 to 4 hours of occurrence. All missiles had penetrated into the brain. Aerobic and anaerobic cultures were taken of the skin wound, brain, and indriven bone fragments. Forty-four of the skin wounds were contaminated,...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1971.34.2part1.0145

    authors: Carey ME,Young H,Mathis JL,Forsythe J

    更新日期:1971-02-01 00:00:00

  • Deep brain stimulation for the early treatment of the minimally conscious state and vegetative state: experience in 14 patients.

    abstract::OBJECTIVE An effective treatment of patients in a minimally conscious state (MCS) or vegetative state (VS) caused by hypoxic encephalopathy or traumatic brain injury (TBI) is not yet available. Deep brain stimulation (DBS) of the thalamic reticular nuclei has been attempted as a therapeutic procedure mainly in patient...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.10.JNS161071

    authors: Chudy D,Deletis V,Almahariq F,Marčinković P,Škrlin J,Paradžik V

    更新日期:2018-04-01 00:00:00