Blood flow in normal and injured monkey spinal cord.

Abstract:

:The authors used indicator fractionation techniques to determine blood flow in normal and bluntly traumatized spinal cords of Macaca rhesus monkeys. Normal flow rates were determined for several levels of spinal cord as well as differential values for white and gray matter from representative areas. Flow rates in traumatized tissue, obtained at several different time intervals up to 4 hours after injury, demonstrated marked differences in regional perfusion of the white matter and gray matter after trauma. Gray matter perfusion was nearly obliterated while white matter blood flow persisted and in fact was higher than uninjured controls. The findings do not support the concept of ischemia as a factor in white matter failure. If toxic pathobiochemical alterations are induced by trauma, it may be possible to reverse these changes by exploiting the preserved white matter blood flow for chemotherapeutic intervention.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Bingham WG,Goldman H,Friedman SJ,Murphy S,Yashon D,Hunt WE

doi

10.3171/jns.1975.43.2.0162

subject

Has Abstract

pub_date

1975-08-01 00:00:00

pages

162-71

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

43

pub_type

杂志文章
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