Vasogenic edema following acute and chronic spinal cord compression in the dog.

Abstract:

:The T-13 spinal cord segment of dogs was compressed both acutely and chronically by means of a balloon catheter. The vascular permeability to protein was assessed using Evans blue albumin (EBA), and the dorsal column evoked potential recorded to monitor conduction failure. With acute compression sufficient to cause conduction failure there was a marked leakage of EBA from the intermediate gray matter, which spread into the dorsolateral white matter. The degree of edema was similar whether the compression was maintained or released. Chronic compression maintained over 4 to 5 hours did not increase vascular permeability, but following release of compression leakage of EBA occurred in the same cord locations observed with leakage from acute compressions. This increased permeability following release of chronic compression may result from reactive hyperemia. Dorsal column conduction returned after the release of both acute and chronic compression. The extravasated EBA was present both in the extracellular space and within cells. The results and their clinical application are discussed.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Griffiths IR

doi

10.3171/jns.1975.42.2.0155

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

155-65

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

42

pub_type

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