Abstract:
OBJECTIVES:To examine associations between inflammation and physical function and potential mediation by white matter hyperintensities (WMHs) in African Americans (AAs) and European Americans (EAs). DESIGN:Cross-sectional analysis using linear and logistic models with generalized estimating equations to account for family clustering, reporting results as regression coefficients (β) and odds ratios (ORs) adjusted for education, alcohol, exercise, body mass index, hypertension, diabetes mellitus, heart disease, cognition, ankle-brachial index, race (site), and supported interactions. SETTING:Genetic Epidemiology Network of Arteriopathy-Genetics of Microangiopathic Brain Injury Study cohort. PARTICIPANTS:AA and EA sibships with two or more siblings with hypertension before age 60 (N = 1,960; 65% female, 51% AA, aged 26-91, 50% obese, 72% hypertensive). MEASUREMENTS:Inflammation (C-reactive protein (CRP), interleukin-6 (IL6), soluble tumor necrosis factor receptors (sTNFRs) 1 and 2, WMH volume (cm(3) ) according to magnetic resonance imaging), walking speed (cm/s) over 25 feet, and mobility difficulty (any self-reported difficulty walking half a mile). RESULTS:In separate models, inflammatory markers were associated with walking speed (sTNFR1: β = -2.74, P < .001; sTNFR2: β = -1.23, P = .03; CRP: β = -1.95, P = .001; IL6: β = -1.24, P = .03) and mobility difficulty (sTNFR1: OR = 1.36, P = .001; sTNFR2: OR = 1.25, P = .005; CRP: OR = 1.22, P = .005; IL6: OR = 1.18, P = .02); the association between WMH volume and sTNFR1 in AA (β = 0.07, P = .06) did not reach typical statistical thresholds. WMH volume was associated with walking speed in AA (β = -3.17, P = .02) but not with mobility difficulty (OR = 1.10, P = .54). Adjusting for WMH did not change associations. CONCLUSION:In young, middle-aged, and older adults with prevalent cardiovascular risk factors, multiple inflammatory biomarkers were associated with slower walking speed independent of microvascular disease in the brain. There was little evidence of mediation by brain WMH volume. Inflammation may contribute to physical function impairments through pathways other than brain microvascular disease, particularly in AAs.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Windham BG,Wilkening SR,Lirette ST,Kullo IJ,Turner ST,Griswold ME,Mosley TH Jrdoi
10.1111/jgs.14229subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1448-55issue
7eissn
0002-8614issn
1532-5415journal_volume
64pub_type
杂志文章abstract:OBJECTIVES:A common assumption is that life-sustaining treatments are much less cost-effective for older patients than for younger patients. We estimated the incremental cost-effectiveness of providing mechanical ventilation and intensive care for patients of various ages who had acute respiratory failure. DESIGN:Retr...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2001.49080.x
更新日期:2001-04-01 00:00:00
abstract::Given the American Geriatrics Society's (AGS) commitment to improving health care for older adults by, among other means, educating older people and their caregivers about their health and healthcare choices, the AGS was delighted when, in late 2011, the American Board of Internal Medicine Foundation invited the Socie...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12226
更新日期:2013-04-01 00:00:00
abstract::Salivary gland function is generally well-preserved in healthy older persons. Similar results are observed in the laboratory rat. Older people are, however, more likely to experience salivary disorders due to disease or its treatment. For many patients with remaining salivary gland parenchymal tissue, improved functio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1989.tb02644.x
更新日期:1989-05-01 00:00:00
abstract::In experience with total joint replacement in the lower extremity, to date, total hip arthroplasty has been the most successful. Total arthroplasty operations as applied to the knee and ankle are giving promising results. These methods offer new avenues for relief of pain and deformity and stabilization of arthritic j...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1977.tb00232.x
更新日期:1977-02-01 00:00:00
abstract::Tetanus is more common in the elderly, who have a higher case-fatality rate than younger age groups. Immunization against tetanus is recommended for all elderly, including nursing home residents, but the tetanus immunization policies of nursing homes are unknown. Nursing home medical directors in Maryland were surveye...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1990.tb03454.x
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVES:To validate the Harmful Behaviors Scale (HBS) as a measure of direct and indirect self-destructive behaviors in nursing home residents and to determine the prevalence of self-destructive behaviors and their relationship to other variables. DESIGN:A cross-sectional study. SETTING:Eleven nursing homes in the...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1532-5415.2002.50070.x
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To investigate the association between different types of physical activity behavior and incident mobility limitation in older men and women and to examine whether muscle parameters mediate these associations. DESIGN:Cohort study with 4.5-year follow-up. SETTING:Metropolitan areas surrounding Pittsburgh, P...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2005.53257.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To identify risk factors for five different subtypes of disability. DESIGN:Prospective cohort study. SETTING:Greater New Haven, Connecticut. PARTICIPANTS:Seven hundred fifty-four community-living residents aged 70 and older and initially nondisabled in four essential activities of daily living (bathing, d...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02443.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To investigate mortality risk and survival time in new-incident cases of cognitive impairment (CI) in old age. DESIGN:Prospective cohort study in six German cities. SETTING:German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). PARTICIPANTS:Two thousand eighty-nine nondemented...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/jgs.14666
更新日期:2017-04-01 00:00:00
abstract::Chronic atrial fibrillation is generally thought to cause stroke by atrial thrombus formation with subsequent embolization. Rheumatic heart disease previously led to most cases of atrial fibrillation, but recent substantial declines in the incidence of rheumatic fever have changed the distribution of causes of atrial ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1985.tb07121.x
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:The impact of parkinsonism on survival in older persons independent of dementia is not well understood. METHODS:Participants in the clinical examination of the Canadian Study of Health and Aging who had parkinsonism and were older than age 65 were identified. The impact of parkinsonism on 5-year survival wa...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2000.tb04701.x
更新日期:2000-04-01 00:00:00
abstract::To improve delirium recognition and care, numerous serum biomarkers have been investigated as potential tools for risk stratification, diagnosis, monitoring, and prognostication of delirium. The literature was reviewed, and no evidence was found to support the clinical use of any delirium biomarker, although certain b...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.2011.03702.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Evidence suggests inflammation is associated with cognitive impairment, but previous epidemiological studies have reported conflicting results. DESIGN:Prospective population-based cohort. SETTING:Epidemiology of Hearing Loss Study participants. PARTICIPANTS:Individuals without cognitive impairment in 1998...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12994
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To compare reports about care experiences of individuals who died within 1 year of survey with reports of those who did not. DESIGN:Medicare Advantage (MA) Consumer Assessment of Healthcare Providers and Systems (CAHPS) surveys asked about care experiences. Survey completion dates were linked to Social Secu...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/jgs.12121
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To examine public opinion regarding certain elements of consent: disclosure, advance directives, substitute decisions, emergency treatment, and advocacy. DESIGN:Cross-sectional random-digit-dialing telephonic survey. SETTING:General public. PARTICIPANTS:One thousand randomly-selected adults living in Ontar...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1993.tb02042.x
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVES:To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia. DESIGN:A cross-sectional comparison of cognitive screening tests to an independent criterion standard evaluation using Diagnostic and Statisti...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2012.03967.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:To provide descriptive epidemiological information on identified depression in nursing home residents. DESIGN:Survey of the 1996 Medical Expenditure Panel Survey-Nursing Home Component (MEPS-NHC). SETTING:Nine hundred fifty-one nursing facilities. PARTICIPANTS:Three thousand seven hundred ten noncomatose ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2003.51458.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:To assess 1-week prevalence of International Classification of Disease, Tenth Edition (ICD-10) current depression, physical comorbidity, associated disability, and healthcare utilization in older primary care patients. Comparisons with younger patients are also reported. DESIGN:Cross-sectional, two-phase ep...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50011.x
更新日期:2002-01-01 00:00:00
abstract::Self-administered questionnaires were sent to all faculty and staff members of the departments of internal medicine and psychiatry in a school of medicine. The questionnaires asked for information about personal characteristics, practice characteristics, and interest in teaching geriatrics. Included also were measures...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1982.tb03703.x
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVES:To examine the combined influence of alcohol use and comorbidity on 20-year mortality in older adults (average age 66 at the time of the baseline survey). DESIGN:Longitudinal analysis of a national probability sample-based cohort study. SETTING:Data sources were the National Health and Nutrition Examinatio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2006.00728.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of standardized neuropsychological tests in the psychometric differentiation of patients with very mild or mild Alzheimer's Disease (AD) and/or major depression presenting in a tertiary clinic with memory/attention complaints. DESIGN:Controlled prospective clinicoexperimental desig...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章
doi:10.1111/j.1532-5415.1995.tb07402.x
更新日期:1995-11-01 00:00:00
abstract::Neurotoxic effects of habitual alcohol consumption were investigated by correlating the subjects' estimates of abstinence or frequency and amount of alcohol consumed with measurements of gray matter blood flow utilizing the 133Xe inhalation method. Two hundred and twenty-two subjects were studied, including 136 health...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1983.tb02198.x
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVE:To determine whether mortality is independently associated with urinary incontinence. DESIGN:6-year prospective study that started in 1983/84. SETTING:A Midwestern County. PARTICIPANTS:Probability sample of 1956 community-residing persons 60 years of age and older in 1983/84. MEASUREMENTS:The independent ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb01749.x
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:To determine the perspectives of seriously ill individuals on reasons for 30-day hospital readmission. DESIGN:A prospective qualitative study was conducted employing individual interviews conducted at bedside. SETTING:Department of Veterans Affairs Greater Los Angeles Healthcare System. PARTICIPANTS:Serio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13238
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:To prospectively examine associations between accelerometer-measured physical activity (PA) and mortality in older women, with an emphasis on light-intensity PA. DESIGN:Prospective cohort study with baseline data collection between March 2012 and April 2014. SETTING:Women's Health Initiative cohort in the ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15201
更新日期:2018-05-01 00:00:00
abstract::The coming decades will see a dramatic rise in the number of homebound adults. These individuals will have multiple medical conditions requiring a team of caregivers to provide adequate care. Home-based primary care (HBPC) programs can coordinate and provide such multidisciplinary care. Traditionally, though, HBPC pro...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.2006.00835.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:To test the applicability and safety of a standardized diagnostic algorithm in geriatric departments and to define the prevalence of different causes of syncope in older patients. DESIGN:Multicenter cross-sectional observational study. SETTING:In-hospital geriatric acute care departments and outpatient cli...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1532-5415.2006.00891.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of protocols or guidelines for selected domains of inpatient care for older adults; to explore associations between hospital characteristics and adoption of these guidelines or protocols. DESIGN:Telephone- and Web-based questionnaire. SETTING:General acute care hospitals in Pennsyl...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1532-5415.2010.03056.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:A widely held dictum in aging research is that heterogeneity in health increases with age, but the basis for this claim has not been fully investigated. We examined heterogeneity at different ages across health characteristics to describe variation and trends; we investigated the comparative importance of be...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16919
更新日期:2020-11-05 00:00:00
abstract:OBJECTIVES:To establish the comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in older adults using the network meta-analysis approach. DESIGN:Systematic review and network meta-analysis. PARTICIPANTS:Individuals aged 60 and older. MEASUREMENT...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,meta分析
doi:10.1111/jgs.13395
更新日期:2015-05-01 00:00:00