当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY期刊下所有文献 > Sub-clinical orthostatic hypotension is associated with greater subjective memory impairment in older adults.

Sub-clinical orthostatic hypotension is associated with greater subjective memory impairment in older adults.

Abstract：

INTRODUCTION:Orthostatic blood pressure (BP) is a measure of cardiovascular autonomic function. Orthostatic BP dysregulation may lie on the causal pathway to dementia. Subjective memory impairment (SMI) is commonly reported by older people some of whom may progress to dementia. We hypothesised that sub-clinical orthostatic hypotension would be associated with SMI and explored these associations according to sex. METHODS:Cross-sectional analysis of data from 4340 participants aged 50 and over collected during the first wave (2009-2011) of the cohort study, The Irish Longitudinal Study on Ageing. Subjective memory was rated according to a 5-point scale ranging from 'poor' to 'excellent'. BP was measured during orthostatic stress using continuous non-invasive beat-to-beat recording over 2 min. RESULTS:2% reported 'poor' subjective memory, 12.3% 'fair' , 38% 'good', 33% 'very good' and 14.6% 'excellent'. After controlling for several potential confounding factors including cardiovascular risk, objective cognition, and depressive symptoms mean systolic orthostatic BP was lowest in those with poor subjective memory: 92.2 mmHg (CI95% = 87.1, 97.3) versus excellent 99.3 mmHg (CI95% = 97.4, 101.2); p = 0.011. Further adjustment for supine systolic BP suggested that men with poor subjective memory reached the lowest average systolic orthostatic BP and had the greatest impairment in systolic orthostatic BP stabilisation to baseline levels at 10 s post-stand (-6.64 mmHg; CI95% = -11.49, -1.79; p = 0.007). CONCLUSIONS:Sub-clinical orthostatic hypotension is associated with SMI, and there are sex-specific relationships evident in this population-based cohort. Subtle cardiovascular autonomic dysfunction may represent a modifiable risk marker at an early stage of cognitive decline in older adults. Copyright © 2016 John Wiley & Sons, Ltd.

journal_name

Int J Geriatr Psychiatry

journal_title

International journal of geriatric psychiatry

authors

O'Hare C,McCrory C,O'Connell MD,Kenny RA

doi

10.1002/gps.4485

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

429-438

issue

eissn

0885-6230

issn

1099-1166

journal_volume

pub_type

杂志文章

在线工具

Sub-clinical orthostatic hypotension is associated with greater subjective memory impairment in older adults.