Abstract:
OBJECTIVE:To correlate neonatal and infant clinical outcome with parasite load in amniotic fluid (AF). METHODS:We conducted a retrospective cohort study of 122 children whose mothers had toxoplasmosis during pregnancy. The children were monitored from birth to 12 months old. Stored AF samples were obtained at maternal diagnosis and tested by quantitative polymerase chain reaction. Gestational age at maternal infection, quantitative polymerase chain reaction results, neonatal anti-Toxoplasma gondii immunoglobulin (Ig) M, and clinical outcome at 12 months were correlated. RESULTS:Maternal infection occurred in 18 of 122 (14.7%) and 104 of 122 (85.2%) women in the first and second trimesters, respectively. At birth, IgM was present in 107 of 122 (87.7%) neonates and 36 (29.5%) were symptomatic. Of these, half occurred in the first and the other half in the second trimester and 6 of 36 had severe infections (16.7% of symptomatic, 4.9% of total), all infected in the first trimester. Parasite load levels were highly variable (median 35 parasites/mL, range 2-30,473). Logistic regression correlated symptomatic infection with gestational age (odds ratio [OR] 0.47, CI 0.31-0.73) and parasite load (OR 2.04, CI 1.23-3.37), but not with positive IgM (OR 6.81, CI 0.86-53.9). Negative correlations were found between gestational age and parasite load (rs -0.780, CI -0.843 to -0.696), gestational age and symptoms (rs -0.664, CI -0.755 to -0.547), but not gestational age and IgM (rs -0.136, CI -0.311 to 0.048). Parasite load levels distributed by percentile showed that all symptomatic patients appeared from the 75th percentile and all severe infections from the 95th percentile. Load rankings showed doubled the OR for each 20 parasite/mL increment. Parasite load was associated with symptomatic infections (area under the curve 0.959, CI 0.908-0.987) as well as gestational age (area under the curve 0.918, CI 0.855-0.960) and both parameters combined (area under the curve 0.969, CI 0.920-0.992). CONCLUSION:Parasite load in AF is associated with the clinical outcome in congenital toxoplasmosis, irrespective of gestational age at maternal infection.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Yamamoto L,Targa LS,Sumita LM,Shimokawa PT,Rodrigues JC,Kanunfre KA,Okay TSdoi
10.1097/AOG.0000000000002131subject
Has Abstractpub_date
2017-08-01 00:00:00pages
335-345issue
2eissn
0029-7844issn
1873-233Xpii
00006250-201708000-00012journal_volume
130pub_type
杂志文章abstract:OBJECTIVE:To identify factors associated with post-term birth and factors associated with adverse outcomes in post-term births. METHODS:The sample was a 10-year cohort (1978-1987) of term (n = 379,445) and post-term (n = 65,796) births from the Medical Birth Registry of Norway. Gestational age was based on mothers' re...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(97)00049-5
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To estimate normal ranges for postpartum maternal vital signs. METHODS:We conducted a multicenter prospective longitudinal cohort study in the United Kingdom. We recruited women before 20 weeks of gestation without significant comorbidities and with accurately dated singleton pregnancies. Women recorded thei...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000004239
更新日期:2021-02-01 00:00:00
abstract::This month we focus on current research in human papillomavirus-related lower anogenital tract disease prevention and screening. Dr. Boardman discusses four recent publications, which are concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along w...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000001081
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Spectral Doppler ultrasound, an important diagnostic tool for the functional assessment of various organs, as yet has no major use in prenatal diagnosis due to the conventional technique's limitation of analyzing only one site at a time. Our aim was to develop a new modality that shows simultaneous studies o...
journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Bombay blood type is among the rarest in the world and is associated with anti-H antibodies. These antibodies cause severe hemolysis when exposed to any blood product except Bombay and have been reported to cause hemolytic disease of the newborn. CASE:A primigravid woman with Bombay blood type received eryt...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181f738f3
更新日期:2011-02-01 00:00:00
abstract::Human immunodeficiency virus (HIV) infections are being seen with greater regularity by the obstetrician-gynecologist. Acquired immunodeficiency syndrome (AIDS), the extreme of the spectrum of HIV infections, is associated with Pneumocystis carinii infection in more than half of newly diagnosed cases. Four cases of AI...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:to evaluate the advantages and pitfalls of the loop electrosurgical excision procedure as applied to the diagnosis and treatment of cervical cancer precursors. METHODS:Loop electrosurgical excision procedure using local anesthesia and colposcopic guidance was performed in an outpatient clinical setting in 11...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/0029-7844(95)00453-x
更新日期:1996-03-01 00:00:00
abstract::Fourteen patients with stage IB or IIA neuroendocrine small-cell cervical cancer were treated either by operation alone or operation in combination with postoperative radiotherapy at the University of California, Irvine Medical Center, and Memorial Medical Center of Long Beach, between January 1979 and February 1986. ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of cerebral velocimetry as a predictor of perinatal outcome in high-risk pregnancies. METHODS:Middle cerebral artery pulsatility index was measured in 576 high-risk pregnancies undergoing umbilical velocimetry. The results of both tests were evaluated with respect to the birth of small f...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(97)00482-1
更新日期:1997-12-01 00:00:00
abstract::As the human immunodeficiency virus (HIV) epidemic affects more women, clinicians are increasingly observing pelvic inflammatory disease (PID) in HIV-infected women. The extent to which PID is a factor in the recognition of HIV or HIV is a factor in the recognition of PID is unknown. Even less is known about how HIV i...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Over a 63-month period beginning January 1, 1977, 258 infants with birth weights of 500-999 g were born alive at one tertiary perinatal center; 170 were offered full intensive care. The mothers of 67 (39.4%) of these 170 infants had been given betamethasone antenatally to accelerate fetal lung maturation. Of the 67 in...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Preeclampsia is a leading cause of morbidity and mortality during pregnancy. The variability of clinical features suggests that preeclampsia is not a single disease. Atypical hemolytic uremic syndrome, resulting from defective regulation of the alternative complement pathway, is less well known and may be mi...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000001340
更新日期:2016-05-01 00:00:00
abstract::Umbilical cord blood gases were measured as objective parameters of neonatal outcome in patients delivered by Silastic vacuum extractor and were compared with those values from patients delivered spontaneously, by forceps, or by sequential use of vacuum and forceps. The results demonstrated no clinically significant d...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::A chemotherapeutic combination consisting of VM-26-vincristine-cisplatin was used to treat 44 consecutive patients with primary advanced or recurrent endometrial carcinomas. Nine complete remissions (20.5%) and 14 partial remissions (31.8%) were recorded. The median duration of remission in responders was 8 months (ra...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::The purpose of the present retrospective study was to examine the relationship between hypertension and abruptio placentae. Two hundred sixty-five consecutive cases of abruption were reviewed, with an emphasis on the occurrence and severity of hypertensive disease. The results confirm a close relationship between abru...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Intrauterine retention of fetal bone is a rare complication of abortion that can cause secondary infertility by an unknown mechanism. We report such a case in which menstrual fluid prostanoids were measured to elucidate the possible pathophysiology. The pattern of prostanoid increases was similar to that seen in intra...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To describe the outcomes of intended home birth in the practices of certified nurse-midwives. METHODS:Twenty-nine US nurse-midwifery practices were recruited for the study in 1994. Women presenting for intended home birth in these practices were enrolled in the study from late 1994 to late 1995. Outcomes for...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,评审
doi:10.1016/s0029-7844(98)00182-3
更新日期:1998-09-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/01.AOG.0000206217.07883.a2
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To document individual variations in the rise in insulin requirements during type I diabetic pregnancies, to relate the degree of increase to maternal characteristics and fetal outcome, and to examine these factors in a subgroup of patients experiencing a large fall in insulin requirement in the third trimes...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Preimplantation genetic diagnosis has been used to decrease or avoid the risk of transmitting identified mutations to offspring. CASE:A 29-year-old woman with spondyloepiphyseal dysplasia congenita and her 30-year-old husband with Marfan syndrome underwent in vitro fertilization with preimplantation genetic...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181c9b316
更新日期:2010-02-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181ea2deb
更新日期:2010-09-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-198003001-00020
更新日期:1980-03-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章,meta分析
doi:10.1097/AOG.0000000000003105
更新日期:2019-03-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::Torulopsis glabrata is a yeast of low virulence and commensal within the female genitourinary tract. The first case of congenital infection with Torulopsis glabrata was reported in 1980. An additional example of perinatal Torulopsis infection which is associated with maternal sickle cell anemia is reported. The most c...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3182204eaa
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To examine the association of body mass index (BMI) and operative time and perioperative morbidity after hysterectomy and determine whether the association varies among abdominal, laparoscopic, and vaginal approaches. METHODS:Data abstracted from the American College of Surgeons National Safety and Quality I...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000000698
更新日期:2015-03-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/aog.0b013e31827e5ab3
更新日期:2013-02-01 00:00:00
abstract::Lumbar spine and femoral neck bone densities of women, aged 35-65, were measured by dual photon bone densitometry. After exclusion of women with spinal and other abnormalities, this study included 233 subjects: 60 menstruant, 91 who underwent natural menopause (56 more than 2 years post-menopause), 45 bilaterally ooph...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To estimate the safety of fertility-conserving surgery for stage IA1 cervical cancer and to analyze predictors of access to conization. METHODS:We analyzed women with stage IA1 cervical cancer aged 40 years or younger who were diagnosed between 1988 and 2005 and recorded in the Surveillance, Epidemiology, an...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181d06b68
更新日期:2010-03-01 00:00:00