当前位置： SCI文献检索 > Pediatrics and Neonatology期刊下所有文献 > Effect of bosentan therapy in persistent pulmonary hypertension of the newborn.

Effect of bosentan therapy in persistent pulmonary hypertension of the newborn.

Abstract：

BACKGROUND:Persistent pulmonary hypertension of the newborn (PPHN) contributes to neonatal hypoxemia and is associated with a high mortality. Some PPHN patients are unresponsive to inhaled nitric oxide (iNO). Bosentan, an oral endothelin-1 receptor antagonist, reduces pulmonary vascular resistance and hence may play a role in the treatment of PPHN. METHODS:A retrospective medical records review was performed in newborns who received oral bosentan as an adjunctive therapy for treatment of PPHN between January 2013 and February 2016 at the neonatal intensive care unit of Songklanagarind Hospital. The main outcomes were the effect of bosentan on oxygenation and hemodynamic status after commencement of treatment and the safety of bosentan. RESULTS:Forty neonates at a median (IQR) gestation of 38 (36.8-40) weeks and an initial median (IQR) oxygen index (OI) of 29.2 (13.4-40.1) received bosentan therapy. Oral bosentan was commenced at a median (IQR) age of 27 (14.5-40.2) hours and the mean (SD) duration of treatment was 6.2 (3.1) days. The OI, alveolar-arterial oxygen difference (AaDO2) and oxygen saturation (SpO2) improved significantly at 2 h after treatment (p = 0.002, p = 0.01 and p < 0.001, respectively). In 21 (52.5%) neonates who received iNO and bosentan, the median OI (IQR) was 34.2 (29.0-42.6) with a significant decrease of OI at 6 h (p = 0.005) after treatment. In 19 (47.5%) neonates who received bosentan alone, the median OI (IQR) was 13.0 (9.8-30.9) with a significant decrease of OI in 2 h (p = 0.01) after treatment. The blood pressures before and after bosentan treatment were not statistically significantly different. The mortality rate was 12.5% (5/40). CONCLUSION:Oral bosentan may be a safe and effective treatment to improve oxygenation in neonates with PPHN. Bosentan can be used as an adjuvant therapy with iNO and can be an alternative therapy option in mild-to-moderate PPHN.

journal_name

Pediatr Neonatol

journal_title

Pediatrics and neonatology

authors

Maneenil G,Thatrimontrichai A,Janjindamai W,Dissaneevate S

doi

10.1016/j.pedneo.2017.02.003

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

58-64

issue

1

eissn

1875-9572

issn

2212-1692

pii

S1875-9572(17)30410-2

journal_volume

59

pub_type

杂志文章

相关文献

Pediatrics and Neonatology文献大全
  • Mesenteric defect with internal herniation in the pediatric emergency department: an unusual presentation of acute abdomen.

    abstract：:Internal herniation is a rare cause of intestinal obstruction, especially in the emergency department. We report a child with acute abdomen resulting from transmesenteric internal herniation of the small bowel. Radiographic findings revealed gaseous distension of the bowel loops in the upper abdominal area with a pauc...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2012.12.008

    authors： Hu MH,Huang GS,Chen JC,Wu CT

    更新日期：2014-04-01 00:00:00

  • Trends in birth weight-specific and -adjusted infant mortality rates in Taiwan between 2004 and 2011.

    abstract：BACKGROUND:A yearly increase in the proportion of very low birth weight (VLBW) live births has resulted in the slowdown of decreasing trends in crude infant mortality rates (IMRs). In this study, we examined the trends in birth weight-specific as well as birth weight-adjusted IMRs in Taiwan. METHODS:We linked three na...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2017.08.013

    authors： Liang FW,Chou HC,Chiou ST,Chen LH,Wu MH,Lue HC,Chiang TL,Lu TH

    更新日期：2018-06-01 00:00:00

  • Parents' views about the vaccination program in Taiwan.

    abstract：PURPOSE:To investigate parents' views about new vaccines, we surveyed the attitudes and awareness toward immunization program among parents of children younger than 14 years in Taiwan. METHODS:Parents of children were invited to complete a questionnaire in a tertiary referral medical center in Kaoshiung, southern Taiw...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2011.02.009

    authors： Tang CW,Huang SH,Weng KP,Ger LP,Hsieh KS

    更新日期：2011-04-01 00:00:00

  • Successful weaning of a laryngeal mask airway after a tongue-lip adhesion operation in a case with cerebro-costo-mandibular syndrome.

    abstract：:Cerebro-costo-mandibular syndrome (CCMS) consists of severe micrognathia, glossoptosis, posterior rib-gap defects and developmental delay. It may cause upper airway obstruction andflail chest, resulting in neonatal hypoxia, and possibly death. Early airway management or surgical intervention to maintain a patent airwa...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/S1875-9572(10)60011-3

    authors： So CY,Ng YY,Peng CY,Hu JM,Chen SJ,Chen JY,Su PH

    更新日期：2010-02-01 00:00:00

  • Estimation of the incidence of Kawasaki disease in Taiwan. A comparison of two data sources: nationwide hospital survey and national health insurance claims.

    abstract：BACKGROUND:Kawasaki disease (KD), first described by Dr. Tomisaku Kawasaki in 1967, was found for the first time in Taiwan in 1976. It continued to occur in increased numbers. For the study of incidence rates and epidemiological features of KD, we conducted five nationwide hospital surveys (NHS) in 1987, 1992, 1994, 20...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2013.05.011

    authors： Lue HC,Chen LR,Lin MT,Chang LY,Wang JK,Lee CY,Wu MH

    更新日期：2014-04-01 00:00:00

  • Automated EEG background analysis to identify neonates with hypoxic-ischemic encephalopathy treated with hypothermia at risk for adverse outcome: A pilot study.

    abstract：BACKGROUND:To improve the objective assessment of continuous video-EEG (cEEG) monitoring of neonatal brain function, the aim was to relate automated derived amplitude and duration parameters of the suppressed periods in the EEG background (dynamic Interburst Interval= dIBIs) after neonatal hypoxic-ischemic encephalopat...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2018.03.010

    authors： Dereymaeker A,Matic V,Vervisch J,Cherian PJ,Ansari AH,De Wel O,Govaert P,De Vos M,Van Huffel S,Naulaers G,Jansen K

    更新日期：2019-02-01 00:00:00

  • Glycogen storage disease type Ib: the first case in Taiwan.

    abstract：:Glycogen storage disease (GSD) type Ib is caused by the deficiency of glucose-6-phosphate translocase activity. The elder brother of the proband died at age 20 months, and GSD Ia, a disease caused by the deficiency of glucose-6-phosphatase, was the diagnosis. Theproband developed hypoglycemia shortly after birth. Diet...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/S1875-9572(09)60048-6

    authors： Hsiao HJ,Chang HH,Hwu WL,Lam CW,Lee NC,Chien YH

    更新日期：2009-06-01 00:00:00

  • Early Erythropoietin Administration does not Increase the Risk of Retinopathy in Preterm Infants.

    abstract：BACKGROUND:Erythropoietin (EPO) administration prevents anemia of prematurity and may be associated with a significant increase in the risk of retinopathy of prematurity (ROP) in preterm infants. Nonetheless, early EPO treatment may prevent damage following retinal neovascularization. The aim of this meta-analysis was ...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.pedneo.2016.03.006

    authors： Chou HH,Chung MY,Zhou XG,Lin HC

    更新日期：2017-02-01 00:00:00

  • Color Doppler echocardiographic study on the incidence and natural history of early-infancy muscular ventricular septal defect.

    abstract：BACKGROUND:Most small muscular ventricular septal defect (M-VSD) types have been diagnosed using color Doppler echocardiography. The purpose of this study was to understand the incidence of small M-VSD in the neonatal period and analyze the natural history of these M-VSDs. MATERIALS AND METHODS:All individuals in our ...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2011.06.003

    authors： Chang JK,Jien WY,Chen HL,Hsieh KS

    更新日期：2011-10-01 00:00:00

  • Lenticulostriate Vasculopathy in Brain Ultrasonography is Associated with Cytomegalovirus Infection in Newborns.

    abstract：BACKGROUND:Lenticulostriate vasculopathy is associated with various disorders, in particular cytomegalovirus infection, which can cause neurological consequences. We wanted to evaluate the association of lenticulostriate vasculopathy and cytomegalovirus infection. We retrospectively collected data on lenticulostriate v...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2015.04.002

    authors： Hong SY,Yang JJ,Li SY,Lee IC

    更新日期：2015-12-01 00:00:00

  • Nystagmus in childhood.

    abstract：:Nystagmus is an involuntary rhythmic oscillation of the eyes, which leads to reduced visual acuity due to the excessive motion of images on the retina. Nystagmus can be grouped into infantile nystagmus (IN), which usually appears in the first 3-6 months of life, and acquired nystagmus (AN), which appears later. IN can...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.pedneo.2014.02.007

    authors： Papageorgiou E,McLean RJ,Gottlob I

    更新日期：2014-10-01 00:00:00

  • Limbic encephalitis in Taiwanese children and adolescence: a single center study.

    abstract：BACKGROUND:Non-viral limbic encephalitis, which may be paraneoplastic or idiopathic, is increasingly recognized in adults and children. Early identification of potential patients, who have neuronal autoantibodies to intracellular or neuronal surface antigens in order to give appropriate immunotherapy, is key to improvi...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2013.01.016

    authors： Chou IJ,Wang HS,Lin JJ,Kuo CF,Lin KL,Chou ML,Hung PC,Hsieh MY,Lin YT,CHEESE Study Group.

    更新日期：2013-08-01 00:00:00

  • Pneumoretroperitoneum and perirenal air associated with pneumothorax in an extremely low-birth-weight infant.

    abstract：:Pneumothorax-associated pneumoretroperitoneum and perirenal air have rarely been reported in infants. We report a case of an extremely low-birth-weight infant who developed pneumoretroperitoneum and perirenal air associated with tension pneumothorax and deteriorated acutely despite prompt pleural water-seal vacuum dra...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2010.12.004

    authors： Karagol BS,Turkbay D,Dilmen U

    更新日期：2011-02-01 00:00:00

  • International Ranking of Infant Mortality Rates: Taiwan Compared with European Countries.

    abstract：BACKGROUND:Rankings of infant mortality rates are commonly cited international comparisons to assess the health status of individual countries. We compared the infant mortality rate of Taiwan with those of European countries for 2004 according to two definitions. METHODS:First, the countries were ranked on the basis o...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2015.07.006

    authors： Liang FW,Lu TH,Wu MH,Lue HC,Chiang TL,Huang YL,Chen LH

    更新日期：2016-08-01 00:00:00

  • Late-onset group B streptococcal meningitis in a neonate with early antibiotic prophylaxis.

    abstract：:An otherwise healthy female baby who had received early postnatal antibiotic prophylaxis because of maternal vaginal group B streptococcal (GBS) colonization died of late-onset GBS meningitis. GBS was isolated from blood and cerebrospinal fluid. Genotyping using pulsed-field gel electrophoresis confirmed that the GBS ...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/S1875-9572(10)60046-0

    authors： Ko TJ,Hsieh WS,Hsueh PR,Chou HC,Lu CY

    更新日期：2010-08-01 00:00:00

  • Nonketotic Hyperglycinemia of Infants in Taiwan.

    abstract：BACKGROUND:Nonketotic hyperglycinemia (NKH) is a rare, inherited disease, with very poor outcome. It is difficult to confirm the diagnosis due to nonspecific presentations and rapid progression. The incidence was reported in a few countries. We report the clinical and genetic features of typical neonatal NKH with novel...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2015.10.008

    authors： Chiu CF,Lin JL,Lin JJ,Tseng MH,Lo FS,Chiang MC

    更新日期：2016-10-01 00:00:00

  • A 12-year-experience with tracheostomy for neonates and infants in northern Taiwan: Indications, hospital courses, and long-term outcomes.

    abstract：BACKGROUND:Tracheostomy is a valuable procedure in infants and neonates with chronic respiratory failure or severe airway obstruction. The aim of this study is to identify the indication, hospital course, and long-term outcome in a cohort of infants who required tracheostomy in a neonatal and pediatric tertiary care ce...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2017.07.003

    authors： Chen CH,Chang JH,Hsu CH,Chiu NC,Peng CC,Jim WT,Chang HY,Lee KS

    更新日期：2018-04-01 00:00:00

  • Association of umbilical cord plasma acid-labile subunit of the insulin-like growth factor ternary complex with anthropometry in term newborns.

    abstract：BACKGROUND:Birth size can affect neonatal morbidity and mortality. The insulin-like growth factor (IGF) system is the most important endocrine factor influencing fetal growth. In the circulation, IGFs (mostly IGF-I) are bound to IGF-binding protein 3 (IGFBP-3) and an acid-labile subunit (ALS) to form a ternary complex....

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2013.09.002

    authors： Tseng YM,Hwang YS,Lu CL,Lin SJ,Tsai WH

    更新日期：2014-04-01 00:00:00

  • Respiratory distress syndrome in preterm neonates in the era of precision medicine: A modern critical care-based approach.

    abstract：:Respiratory distress syndrome (RDS) was recognized to be caused by primary surfactant deficiency almost 70 years ago and continuous positive airway pressure was introduced approximately 50 years ago. Since then, there have been many developments in neonatology; we know many things but others are still controversial. T...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2020.11.005

    authors： De Luca D

    更新日期：2020-12-05 00:00:00

  • Positive end-expiratory pressure during resuscitation at birth in very-low birth weight infants: A randomized-controlled pilot trial.

    abstract：BACKGROUND:There is limited evidence of the effect of positive end-expiratory pressure (PEEP) during resuscitation soon after birth. Premature neonates may experience respiratory distress from surfactant insufficiency and providing PEEP after the very first breath, may improve outcomes following appropriate resuscitati...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pedneo.2017.12.002

    authors： Kitsommart R,Nakornchai K,Yangthara B,Jiraprasertwong R,Paes B

    更新日期：2018-10-01 00:00:00

  • The prevalence of undernutrition upon hospitalization in children in a developing country: A single hospital study from Malaysia.

    abstract：BACKGROUND:Undernourished children who require hospital care have a longer duration of hospitalization and respond poorly to modern medical therapy. The objective of the present study was to ascertain the nutritional status of children admitted to a pediatric tertiary center in Malaysia and the risk factors leading to ...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2016.08.010

    authors： Lee WS,Ahmad Z

    更新日期：2017-10-01 00:00:00

  • The immunoregulatory effects of caffeic acid phenethyl ester on the cytokine secretion of peripheral blood mononuclear cells from asthmatic children.

    abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the airways for which current treatments are mainly based on pharmacological interventions, such as glucocorticoid therapy. Our objective was to study the immunoregulatory effects of caffeic acid phenethyl ester (CAPE, a phytochemical synthesized from propolis) on ...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2011.08.005

    authors： Sy LB,Yang LK,Chiu CJ,Wu WM

    更新日期：2011-12-01 00:00:00

  • The Role of Heated Humidified High-flow Nasal Cannula as Noninvasive Respiratory Support in Neonates.

    abstract：:Recently, heated humidified high-flow nasal cannula (HHHFNC) has been introduced and applied as a noninvasive respiratory support in neonates. Although HHHFNC is widely used in neonates presenting with respiratory distress, the efficiency and safety when compared with nasal continuous positive airway pressure or nonin...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.pedneo.2016.08.007

    authors： Chao KY,Chen YL,Tsai LY,Chien YH,Mu SC

    更新日期：2017-08-01 00:00:00

  • Immunoglobulin Concentrations in Plasma and Saliva During the Neonatal Period.

    abstract：BACKGROUND:Screening for infectious diseases in newborns using immunoglobulin (Ig)A-, IgM-, and IgE-specific antibodies is expensive and impractical. To determine if total levels of these Igs can be used for screening purposes, thus simplifying the process, their basic levels in the 1(st) month of extrauterine life nee...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2015.06.005

    authors： Pineda-Martínez S,Hernández-Islas JL,Escobedo-Torres MP,Paredes-Alonzo IE,López-Candiani C,Correa D,Vela-Amieva M

    更新日期：2016-06-01 00:00:00

  • Influence of changing the diameter of the bubble generator bottle and expiratory limb on bubble CPAP: an in vitro study.

    abstract：BACKGROUND:The noisy component of bubble continuous positive airway pressure (CPAP) is thought to contribute to breathing efficiency and lung volume recruitment, mainly because of stochastic resonance. The magnitude and frequency of the superimposed noise are vital to this process. We wanted to evaluate the in vitro ef...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2012.08.013

    authors： Wu CS,Lee CM,Yuh YS,Hua YM

    更新日期：2012-12-01 00:00:00

  • Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population.

    abstract：BACKGROUND:To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. MATERIAL AND METHODS:Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using t...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.pedneo.2018.07.002

    authors： Gao X,Ma F,Hao H,Dai Y,Liu W,Xiao X,Gao P,Li S

    更新日期：2019-04-01 00:00:00

  • Prevalence and pathogen distribution of neonatal sepsis among very-low-birth-weight infants.

    abstract：BACKGROUND:Neonatal sepsis contributes to great mortality and morbidity among very-low-birth-weight (VLBW) infants. Prevalence and pathogen distribution of sepsis in the neonatal intensive care units (NICUs) vary with time and geographic location. Such information serves as a guide for selection of empirical antibiotic...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2012.06.003

    authors： Lim WH,Lien R,Huang YC,Chiang MC,Fu RH,Chu SM,Hsu JF,Yang PH

    更新日期：2012-08-01 00:00:00

  • Pigtail catheters versus traditional chest tubes for pneumothoraces in premature infants treated in a neonatal intensive care unit.

    abstract：BACKGROUND:Pneumothorax is more frequent in the neonatal period, especially among premature infants. Pigtail catheters have been shown to be as effective as and less invasive than traditional chest tubes in adults; however, data regarding premature infants are limited. We aimed to compare the efficacy, safety, and comp...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2014.01.002

    authors： Wei YH,Lee CH,Cheng HN,Tsao LT,Hsiao CC

    更新日期：2014-10-01 00:00:00

  • Validity of biomarkers in screening for neonatal sepsis - A single center -hospital based study.

    abstract：BACKGROUND:The diagnosis of neonatal sepsis still considered to be a challenge for both clinicians and the laboratory due to the non-specific clinical presentations. The present study aimed to compare and assess the diagnostic & prognostic values of C-reactive protein (CRP), high sensitivity CRP (hsCRP), presepsin, int...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/j.pedneo.2018.05.001

    authors： Rashwan NI,Hassan MH,Mohey El-Deen ZM,Ahmed AE

    更新日期：2019-04-01 00:00:00

  • Relationship between perinatal and neonatal indices and intelligence quotient in very low birth weight infants at the age of 6 or 8 years.

    abstract：BACKGROUND:The majority of children born with very low birth weight (VLBW; < 1500g) enter mainstream schools. They experience significant neurodevelopmental disabilities during childhood. The specific aims of our study were to evaluate the neonatal outcomes of VLBW infants and whether they would influence intelligence ...

    journal_title：Pediatrics and neonatology

    pub_type： 杂志文章

    doi：10.1016/S1875-9572(08)60005-4

    authors： Mu SC,Lin CH,Chen YL,Chang CH,Tsou KI

    更新日期：2008-04-01 00:00:00