Abstract：
:This paper discusses the theory and implementation of a modular data analysis system for the calculation and imaging of regional cerebral blood flow. The program may be generalized to any system requiring instantaneous and controllable visual data display, and we have set it up for compartmental analysis as described by the Fick equation with certain correction factors. We have included flow charts of the program source code and data paths for the various modules. We also describe the functional hardware components necessary for the execution of these algorithms. Finally, analyzed data are represented from a set of experiments employing differential visual stimulation. The results obtained using our methods are comparable to those in the existing literature; they are more accurately and easily obtained, and have the added power of manipulable digitization of the original image without loss of data.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Gitelman DR,Toga AWdoi
10.1016/0169-2607(89)90091-6subject
Has Abstractpub_date
1989-05-01 00:00:00pages
59-69issue
1eissn
0169-2607issn
1872-7565pii
0169-2607(89)90091-6journal_volume
29pub_type
杂志文章abstract：:A program for action potential waveform analysis based on a PC compatible computer is described. Single or averaged action potentials are analyzed by obtaining its first derivative and using criteria which allow automatic measurement of several action potential components, including: depolarization rate, repolarizatio...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00053-5
更新日期：2000-06-01 00:00:00
abstract：:Cardiac MR image-based predictive models integrating statistical atlases of heart anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease, a major cause of death worldwide. Such atlases have been built from diffusion tensor (DT) images and can be used in anisotropic models for personalized...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105200
更新日期：2020-04-01 00:00:00
abstract：:Properly representing the heterogeneous distribution of bone tissue material properties is a key step in constructing subject-specific finite element (FE) bone models from computed tomography (CT) data. Conventional methods represent heterogeneity by subjectively grouping bone of similar attenuation together. A new te...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.11.009
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hepatocellular ballooning is an important histological parameter in the diagnosis of nonalcoholic steatohepatitis (NASH), and it is considered to be a morphological pattern that indicates the severity and the progression to cirrhosis and liver-related deaths. There remains uncertainty about the...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105614
更新日期：2020-10-01 00:00:00
abstract：:Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection proces...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.02.005
更新日期：2008-08-01 00:00:00
abstract：:There are numerous programs ongoing to analyze environmental exposure of humans to xenobiotic chemicals via biomonitoring measurements (e.g.: EU ESBIO, COPHES; US CDC NHANES; Canadian Health Measures Survey). The goal of these projects is to determine relative trends in exposure to chemicals, across time and subpopula...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.04.014
更新日期：2012-11-01 00:00:00
abstract：:The mixture cure model is a special type of survival models and it assumes that the studied population is a mixture of susceptible individuals who may experience the event of interest, and cure/non-susceptible individuals who will never experience the event. For such data, standard survival models are usually not appr...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.08.013
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:T-wave alternans (TWA) is a fluctuation of the ST-T complex occurring on an every-other-beat basis of the surface electrocardiogram (ECG). It has been shown to be an informative risk stratifier for sudden cardiac death, though the lack of gold standard to benchmark detection methods has promote...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.04.005
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The understanding of the bonds and the relationships between the respiratory signals, i.e. the airflow, the mouth pressure, the relative temperature and the relative humidity during breathing may provide the improvement on the measurement methods of respiratory mechanics and sensor designs or ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.10.003
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:For more than 20 years, Higuchi's fractal dimension (HFD), as a nonlinear method, has occupied an important place in the analysis of biological signals. The use of HFD has evolved from EEG and single neuron activity analysis to the most recent application in automated assessments of different c...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/j.cmpb.2016.05.014
更新日期：2016-09-01 00:00:00
abstract：:This paper compares bibliographic retrieval using current MeSH (Medical Subject Headings) to bibliographic retrieval using explicitly coded semantic relationships between index terms. In a previous study, ten lists of abstracts, each list containing 20-40 papers discussing a specific pair of terms, were analyzed to id...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90084-3
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Type 2 diabetes mellitus (T2DM) complications seriously affect the quality of life and could not be cured completely. Actions should be taken for prevention and self-management. Analysis of warning factors is beneficial for patients, on which some previous studies focused. They generally used t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105302
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:In cardiac medical imaging, the extraction and segmentation of the part of interest is the key to the diagnosis of heart disease. Due to irregular diastole and contraction, magnetic resonance imaging (MRI) images have poorly defined boundaries, and traditional segmentation algorithms have poor performance. In...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105755
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Over the years, medical image registration has been widely used in various fields. However, different application characteristics, such as scale, computational complexity, and optimization goals, can cause problems. Therefore, developing an optimization algorithm based on clustering calculation is crucial. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105432
更新日期：2020-08-01 00:00:00
abstract：:Tight glycemic control (TGC) has shown benefits in ICU patients, but been difficult to achieve consistently due to inter- and intra- patient variability that requires more adaptive, patient-specific solutions. STAR (Stochastic TARgeted) is a flexible model-based TGC framework accounting for patient variability with a ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.07.003
更新日期：2012-11-01 00:00:00
abstract：:When analyzing clinical data with binary outcomes, the parameter estimates and consequently the odds ratio estimates of a logistic model sometimes do not converge to finite values. This phenomenon is due to special conditions in a data set and known as 'separation'. Statistical software packages for logistic regressio...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(02)00088-3
更新日期：2003-06-01 00:00:00
abstract：:One approach of improving metabolic control in type I diabetic patients is the application of computer-aided procedures aimed at supporting the decision on optimal therapeutic regimens. To accomplish this, a complex strategy was developed which in an individual patient permits (1) the evaluation of metabolic data by m...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90103-g
更新日期：1990-07-01 00:00:00
abstract：:This paper describes an electronic database for handling the interactions between active principles administered to various patients. The computer used is a personal computer with adequate mass memory, software, and data obtained from pharmacological sources. The main features of this work are: 'all-patient' orientati...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90147-8
更新日期：1989-03-01 00:00:00
abstract：:Atrial fibrillation (AF) is the commonest arrhythmia, yet the mechanisms of its onset and persistence are incompletely known. Although techniques for quantitative assessment have been investigated, there have been few attempts to integrate this information to advance disease treatment protocols. In this review, key qu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/j.cmpb.2019.06.017
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:The breast dense tissue percentage on digital mammograms is one of the most commonly used markers for breast cancer risk estimation. Geometric features of dense tissue over the breast and the presence of texture structures contained in sliding windows that scan the mammograms may improve the predictive abili...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.05.022
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Empirical antimicrobial prescription strategies have been proposed to counteract the selection of resistant pathogenic strains. The respective merits of such strategies have been debated. Rather than comparing a finite number of policies, we take an optimization approach and propose a solution...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105767
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In this paper an information theory based multiscale singular value decomposition (SVD) is proposed for multilead electrocardiogram (ECG) signal processing. The shrinkage of singular values for different multivariate multiscale matrices at wavelet scales is based on information content. It aims...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.01.010
更新日期：2016-06-01 00:00:00
abstract：:Synchronous averaging over time locked single-trial of event-related potential (ERP) is known as the simplest scheme to extract P300 component. This method assumes the P300 features are invariant through the time while they are affected by factors like brain fatigue and habitation. In this study, a new scheme is propo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.04.014
更新日期：2017-07-01 00:00:00
abstract：:Alzheimer's Disease (AD) is one of the leading causes of death in developed countries. From a research point of view, impressive results have been reported using computer-aided algorithms, but clinically no practical diagnostic method is available. In recent years, deep models have become popular, especially in dealin...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105242
更新日期：2020-04-01 00:00:00
abstract：:The aim of segmentation of tumor regions in positron emission tomography (PET) is to provide more accurate measurements of tumor size and extension into adjacent structures, than is possible with visual assessment alone and hence improve patient management decisions. We propose a segmentation energy function for the g...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.10.009
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults and Temozolomide (TMZ) is an effective chemotherapeutic agent for its treatment. In Silico models of GBM growth provide an appropriate foundation for analysis and comparison of different regimens. We propose a mathematical frame...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105443
更新日期：2020-09-01 00:00:00
abstract：:An automated system is described that screens requests for laboratory investigations from GPs and delivers feedback with respect to the adequacy of the requests. The system has to replace and extend the current system in which feedback is provided on a manual basis each half year, based on the tests requested during a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(96)01742-n
更新日期：1996-07-01 00:00:00
abstract：:The discovery of the radioimmunoassay for the measurement of insulin concentration stimulated several clever studies which showed, both in vitro and in vivo, the peculiar biphasic pattern of the beta-cell response to glucose stimulation. Physiologists took the challenge to describe with mathematical models those data,...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90059-0
更新日期：1994-01-01 00:00:00
abstract：:The increasing flow of short time series microarray experiments for the study of dynamic cellular processes poses the need for efficient clustering tools. These tools must deal with three primary issues: first, to consider the multi-functionality of genes; second, to evaluate the similarity of the relative change of a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.05.025
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:The augmentation of cooling or heating in a mechanical and industrial process may create a saving in energy, decrease process time, protract the working existence of hardware and raise thermal rating. A few procedures are even influenced subjectively by the action of increased heat transport. The advancement...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105017
更新日期：2019-10-01 00:00:00
