Abstract:
:Alzheimer's Disease (AD) is one of the leading causes of death in developed countries. From a research point of view, impressive results have been reported using computer-aided algorithms, but clinically no practical diagnostic method is available. In recent years, deep models have become popular, especially in dealing with images. Since 2013, deep learning has begun to gain considerable attention in AD detection research, with the number of published papers in this area increasing drastically since 2017. Deep models have been reported to be more accurate for AD detection compared to general machine learning techniques. Nevertheless, AD detection is still challenging, and for classification, it requires a highly discriminative feature representation to separate similar brain patterns. This paper reviews the current state of AD detection using deep learning. Through a systematic literature review of over 100 articles, we set out the most recent findings and trends. Specifically, we review useful biomarkers and features (personal information, genetic data, and brain scans), the necessary pre-processing steps, and different ways of dealing with neuroimaging data originating from single-modality and multi-modality studies. Deep models and their performance are described in detail. Although deep learning has achieved notable performance in detecting AD, there are several limitations, especially regarding the availability of datasets and training procedures.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Ebrahimighahnavieh MA,Luo S,Chiong Rdoi
10.1016/j.cmpb.2019.105242subject
Has Abstractpub_date
2020-04-01 00:00:00pages
105242eissn
0169-2607issn
1872-7565pii
S0169-2607(19)31094-6journal_volume
187pub_type
杂志文章abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults and Temozolomide (TMZ) is an effective chemotherapeutic agent for its treatment. In Silico models of GBM growth provide an appropriate foundation for analysis and comparison of different regimens. We propose a mathematical frame...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105443
更新日期:2020-09-01 00:00:00
abstract::An interactive Pascal program for use in the IBM-PC and compatible computers is presented. It simulates the activation of integral membrane proteins involved in ionic transport. The program allows variation of the number of transport proteins, ionic concentrations, permeability ratios, voltage dependence of permeabili...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(89)90089-8
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Analysis of glomeruli geometry is important in histopathological evaluation of renal microscopic images. Due to the shape and size disparity of even glomeruli of same kidney, automatic detection of these renal objects is not an easy task. Although manual measurements are time consuming and at t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.08.011
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:With ongoing interest in CNT nanofluids and materials in biotechnology, energy and environment, microelectronics, composite materials etc., the current investigation is carried out to analyze the effects of variable viscosity and thermal conductivity of CNT nanofluids flow driven by cilia indu...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.08.001
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In the last decade, Ultrasound-Guided Regional Anesthesia (UGRA) gained importance in surgical procedures and pain management, due to its ability to perform target delivery of local anesthetics under direct sonographic visualization. However, practicing UGRA can be challenging, since it require...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2018.03.013
更新日期:2018-07-01 00:00:00
abstract::Simulation of the behaviour of elastic objects in real time is one of the present objectives of computer graphics. One of its fields of application lies in virtual reality, mainly in surgery simulation systems. Models used for the construction of objects with deformable behaviour in computer graphics are known as defo...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(00)00093-6
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Strabismus is an eye movement disorder in which shows the abnormal ocular deviation. Cover tests have mainly been used in the clinical diagnosis of strabismus for treatment. However, the whole process depends on the doctor's level of experience, which could be subjected to several factors. In t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105132
更新日期:2020-03-01 00:00:00
abstract::Epilepsy Expert is a decision support system based on the International Classification of Epilepsies and Epileptic Syndromes (1989). The aim of this study was to evaluate the Epilepsy Expert. First the diagnostic performance was validated. This was done in 3 stages: collection of the patient cases, determination of th...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90206-2
更新日期:1994-11-01 00:00:00
abstract::A Monte Carlo model of steady-state light transport in multi-layered tissues (MCML) has been coded in ANSI Standard C; therefore, the program can be used on various computers. Dynamic data allocation is used for MCML, hence the number of tissue layers and grid elements of the grid system can be varied by users at run ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(95)01640-f
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We describe and illustrate use of DISTING, a novel web application for computing alternative structurally identifiable linear compartmental models that are input-output indistinguishable from a postulated linear compartmental model. Several computer packages are available for analysing the str...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.02.025
更新日期:2017-05-01 00:00:00
abstract::A physician's problem-solving performance improves with experience. The performance of most medical expert systems does not. The author has developed a diagnosis program for coronary disease that improves its performance by remembering and learning from cases that it has already solved. The program diagnoses commonly-...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(89)90070-9
更新日期:1989-10-01 00:00:00
abstract::The Medicare program, the largest health insurance program in the United States, is clearly at a crossroads as it enters its third decade. Historical increases in health care expenditures, plus a changing political and economic landscape, have set the groundwork for policy reform. Two basic reform strategies--reimburs...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(87)90055-1
更新日期:1987-09-01 00:00:00
abstract::Characterization of carotid atherosclerosis and classification into either symptomatic or asymptomatic is crucial in terms of diagnosis and treatment planning for a range of cardiovascular diseases. This paper presents a computer-aided diagnosis (CAD) system (Atheromatic) that analyzes ultrasound images and classifies...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2012.09.008
更新日期:2013-04-01 00:00:00
abstract::A current trend in genomics is the investigation of the cell mechanism using different technologies, in order to explain the relationship among genes, molecular processes and diseases. For instance, the combined use of gene-expression arrays and genomic arrays has been demonstrated as an effective instrument in clinic...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2013.04.006
更新日期:2013-08-01 00:00:00
abstract::For microdosimetric calculations event-by-event Monte Carlo (MC) methods are considered the most accurate. The main shortcoming of those methods is the extensive requirement for computational time. In this work we present an event-by-event MC code of low projectile energy electron and proton tracks for accelerated mic...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2013.09.009
更新日期:2014-01-01 00:00:00
abstract::Articular cartilage (AC) is a biological tissue that allows the distribution of mechanical loads and movement of joints. The presence of these mechanical loads influences the behavior and physiological condition of AC. The loads may cause damaged by fatigue through injuries due to repeated accumulated stresses. The ai...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2011.02.003
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:For diagnosis of arrhythmic heart problems, electrocardiogram (ECG) signals should be recorded and monitored. The long-term signal records obtained are analyzed by expert cardiologists. Devices such as the Holter monitor have limited hardware capabilities. For improved diagnostic capacity, it w...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.05.004
更新日期:2019-07-01 00:00:00
abstract::This paper describes the processing and transformation of medical data from a clinical database to a statistical data matrix. Precise extraction and linking tools must be available for the desired data to be processed for statistical purposes. We show that flexible mechanisms are required for the different types of us...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(00)00130-9
更新日期:2001-09-01 00:00:00
abstract::A microcomputer program in BASIC for predicting percentage of occurrence of electroshock-induced convulsion in mice was designed. A formula published by the author to express the mathematical relationship among the drug dose, the time, and the biological response was used in this program. Analysis of the actual, and t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(89)90177-6
更新日期:1989-01-01 00:00:00
abstract::Tokyo Hitachi Hospital, Hitachi Ltd., has used a hospital-wide PACS for over 1 year. The system runs a 100 Mb/s optical fiber network over the whole hospital including wards and outpatient clinic rooms, with 11 image workstations. The network links digital imaging modalities such as X-CT, MRI, computed radiography (CR...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90190-2
更新日期:1994-05-01 00:00:00
abstract::Renal dysfunction is a major problem in the management of critically ill patients. Monitoring of renal parameters over time is a prerequisite for detection of any significant deterioration of kidney function. Thus, we developed a knowledge-base for the dynamic monitoring of renal function of critically ill patients. A...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(99)00044-9
更新日期:2000-05-01 00:00:00
abstract::In this paper we discuss the SIMID tool for simulation of the spread of infectious disease, enabling spatio-temporal visualization of the dynamics of influenza outbreaks. SIMID is based on modern random network methodology and implemented within the R and GIS frameworks. The key advantage of SIMID is that it allows no...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2013.01.007
更新日期:2013-06-01 00:00:00
abstract::We propose a new algorithm for optimising sampling times for population pharmacokinetic experiments using D-optimality. The algorithm was used in conjunction with the population Fisher information matrix as implemented in MATLAB (PFIM 1.1 and 1.2) to evaluate population pharmacokinetic designs. The new algorithm based...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2005.07.001
更新日期:2005-11-01 00:00:00
abstract::A 3-D measurement and evaluation system for facial forms was developed with a liquid crystal range finder (LCRF). Its mechanical resolution was approximately/= 0.4 mm, and it was capable of measuring >30000 points from the entire facial surface in one second. An original program was developed to identify facial landma...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(98)00064-9
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE AND BACKGROUND:This article featuring the peristaltic transport of viscous material with variable properties (i.e. temperature dependent viscosity and thermal conductivity) through curved configuration. Fluid saturating through porous channel walls of uniform space. Entropy generation consideration here is to...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105045
更新日期:2020-04-01 00:00:00
abstract::The popularity of the use of Apple II/IIe hardware in medical applications is evidenced by the variety of articles devoted to the use of this hardware in biomedical research and medical practice. Many of these applications are of a stochastic nature, including simulations, and depend on the Applesoft random number gen...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(88)90002-8
更新日期:1988-05-01 00:00:00
abstract::Label fusion multi-atlas approaches for image segmentation can give better segmentation results than single atlas methods. We present a multi-atlas label fusion strategy based on probabilistic weighting of distance maps. Relationships between image similarities and segmentation similarities are estimated in a learning...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2012.12.006
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The use of objective detection techniques applied to the auditory steady-state responses (ASSRs) for the assessment of auditory thresholds has been investigated over the years. The idea consists in setting up the audiometric profile without subjective inference from patients and evaluators. The...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2018.01.031
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Over the years, medical image registration has been widely used in various fields. However, different application characteristics, such as scale, computational complexity, and optimization goals, can cause problems. Therefore, developing an optimization algorithm based on clustering calculation is crucial. ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105432
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Diagnosis of Parkinson's with higher accuracy is always desirable to slow down the progression of the disease and improved quality of life. There are evidences of inherent neurological differences between male and females as well as between elderly and adults. However, the potential of such ge...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105305
更新日期:2020-06-01 00:00:00