Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action.


:The aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for drimenol. For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC50 values of 80, 92, 80 and 314ppm, respectively. These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80ppm of drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed.


Pestic Biochem Physiol


Robles-Kelly C,Rubio J,Thomas M,Sedán C,Martinez R,Olea AF,Carrasco H,Taborga L,Silva-Moreno E




Has Abstract


2017-09-01 00:00:00












  • Deltamethrin affects the expression of voltage-gated calcium channel α1 subunits and the locomotion, egg-laying, foraging behavior of Caenorhabditis elegans.

    abstract::Deltamethrin belongs to the class of synthetic pyrethroids, which are being widely used as insecticides in agricultural practices. Voltage-gated sodium channels (VGSCs) are the primary targets of these chemicals for toxicity to insects. Caenorhabditis elegans (C. elegans) does not have VGSCs but is susceptible to delt...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Zeng R,Yu X,Tan X,Ye S,Ding Z

    更新日期:2017-05-01 00:00:00

  • Mosquitocidal activity of p,p'-difluoro-diphenyl-trichloroethane (DFDT).

    abstract::New insecticides are urgently needed for the control of arthropod vectors of public health diseases. As resistance to many insecticides used for the control of public health pests is ubiquitous, all available chemistries should be evaluated for their potential to effectively control both insecticide-susceptible and in...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Norris EJ,Demares F,Zhu X,Bloomquist JR

    更新日期:2020-11-01 00:00:00

  • Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes.

    abstract::Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Ahmadian E,Eftekhari A,Kavetskyy T,Khosroushahi AY,Turksoy VA,Khalilov R

    更新日期:2020-07-01 00:00:00

  • One pot solvothermal synthesis of novel fluorescent phloem-mobile phenylpyrazole amide pesticides fused olefin moieties to enhance insecticidal bioactivities and photodegradation properties.

    abstract::In order to find a novel type of fluorescent phloem-mobile insecticides, a facile one-pot solvothermal strategy via fipronil addition-elimination substitution reaction with the corresponding acyl chloride derivatives has been employed to construct series of phenylpyrazole amide derivatives (PAs) fused olefin moieties ...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Wu Z,Du Y,Zhou Q,Chen L

    更新日期:2020-02-01 00:00:00

  • Proteomic analysis of Fusarium graminearum treated by the fungicide JS399-19.

    abstract::JS399-19 (2-cyano-3-amino-3-phenylancryic acetate), a novel cyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum. Treated with JS399-19, mycelium of F. graminearum was distorted and swelled. The embranchment increased. In order to investigate the effect of JS399...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Hou Y,Zheng Z,Xu S,Chen C,Zhou M

    更新日期:2013-09-01 00:00:00

  • Alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on Aedes aegypti larvae.

    abstract::Aedes aegypti mosquitoes are responsible for dengue, chikungunya, and Zika virus transmission in tropical and subtropical areas around the world. Due to the absence of vaccines or antiviral drugs for human treatment, the majority of control strategies are targeted at Ae. aegypti elimination. Our research on mosquito c...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Borrero Landazabal MA,Carreño Otero AL,Kouznetsov VV,Duque Luna JE,Mendez-Sanchez SC

    更新日期:2018-01-01 00:00:00

  • Mechanism of Safening Action of Dymuron and Its Two Monomethyl Analogues against Bensulfuron-methyl Injury to Rice (Oryza sativa)

    abstract::The comparative efficacy and mechanism of action of the herbicide dymuron and its two optically active monomethyl analogues, (R)-1-(alpha-methylbenzyl)-3-(p-tolylurea) (R-MBTU) and S-MBTU, as safeners of rice against injury from bensulfuron-methyl were investigated. Bioassays using etiolated seedlings of rice (Oryza s...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Omokawa H,Wu J,Hatzios KK

    更新日期:1996-05-01 00:00:00

  • Effects of azinphos-methyl on enzymatic activity and cellular immune response in the hemolymph of the freshwater snail Chilina gibbosa.

    abstract::The use of a battery of biomarkers, especially those more closely related to species integrity, is desired for more complete ecotoxicological assessments of the effects of pesticide contamination on aquatic organisms. The phosphorodithioate azinphos-methyl has been intensively used in agriculture worldwide and have be...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Herbert LT,Castro JM,Bianchi VA,Cossi PF,Luquet CM,Kristoff G

    更新日期:2018-09-01 00:00:00

  • Effects and inhibition mechanism of phenazine-1-carboxamide on the mycelial morphology and ultrastructure of Rhizoctonia solani.

    abstract::The purpose of this research was to explore the effect of phenazine-1-carboxamide (PCN) on Rhizoctonia solani and to elucidate its mechanisms of action. The toxicity of PCN to R. solani was measured using a growth rate method. The results indicated that PCN inhibited R. solani with a 50% effective concentration (EC50)...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Xiang Y,Zhang Y,Wang C,Liu S,Liao X

    更新日期:2018-05-01 00:00:00

  • Chlorine dioxide enhances lipid peroxidation through inhibiting calcium-independent cellular PLA2 in larvae of the Indianmeal moth, Plodia interpunctella.

    abstract::Polyunsaturated fatty acids usually undergo lipid peroxidation induced by reactive oxygen species (ROS). Calcium-independent cellular phospholipase A2 (iPLA2) can maintain fatty acid compositions in phospholipids depending on physiological conditions. An insect iPLA2 (Pi-iPLA2) was predicted from the transciptome of t...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Han GD,Na J,Chun YS,Kumar S,Kim W,Kim Y

    更新日期:2017-11-01 00:00:00

  • Differential metabolism of neonicotinoids by brown planthopper, Nilaparvata lugens, CYP6ER1 variants.

    abstract::Imidacloprid is very effective in controlling Nilaparvata lugens Stål, which severely damages rice plants. Following heavy imidacloprid use, imidacloprid-resistant N. lugens, which showed cross-resistance to other neonicotinoids, appeared. We used the baculovirus/Sf9 expression system to express CYP6ER1 variants carry...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Hamada A,Stam L,Nakao T,Kawashima M,Banba S

    更新日期:2020-05-01 00:00:00

  • Seed treatment and foliar application of methyl salicylate (MeSA) as a defense mechanism in rice plants against the pathogenic bacterium, Xanthomonas oryzae pv. oryzae.

    abstract::Methyl salicylate (MeSA) is a volatile biological compound synthesized from salicylic acid (SA) and is a plant hormone that helps defend against pests and pathogens. A major bacterial pathogen of rice, Xanthomonas oryzae pv. oryzae (Xoo) causes severe disease. Seed and plant treatments with MeSA can stimulate the defe...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Kalaivani K,Maruthi-Kalaiselvi M,Senthil-Nathan S

    更新日期:2021-01-01 00:00:00

  • Molecular basis of multiple resistance to ACCase- and ALS-inhibiting herbicides in Alopecurus japonicus from China.

    abstract::Fenoxaprop-P-ethyl-resistant Alopecurus japonicus has become a recurring problem in winter wheat fields in eastern China. Growers have resorted to using mesosulfuron-methyl, an acetolactate synthase (ALS)-inhibiting herbicide, to control this weed. A single A. japonicus population (AH-15) resistant to fenoxaprop-P-eth...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Bi Y,Liu W,Guo W,Li L,Yuan G,Du L,Wang J

    更新日期:2016-01-01 00:00:00

  • Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster.

    abstract::Rotenone, a naturally occurring and commonly used pesticide, has been established as a model for inducing Parkinson's Disease (PD) in rodents. Kolaviron is a biflavonoid complex from Garcinia kola seeds with anti-oxidative and anti-inflammatory properties. Here, we evaluated the ameliorative role of Kolaviron on roten...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Farombi EO,Abolaji AO,Farombi TH,Oropo AS,Owoje OA,Awunah MT

    更新日期:2018-02-01 00:00:00

  • Leaf proteome analysis provides insights into the molecular mechanisms of bentazon detoxification in rice.

    abstract::Bentazon is a widely used herbicide that selectively removes broad-leaf weeds by competing with plastoquinone for the binding site in the D1 protein and interrupting the PET (photosynthetic electron transfer) chain. However, monocotyledonous plants, such as rice, show strong resistance to bentazon due to CYP81A6 induc...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Fang Y,Lu H,Chen S,Zhu K,Song H,Qian H

    更新日期:2015-11-01 00:00:00

  • Photosynthetic and antioxidative alterations in coffee leaves caused by epoxiconazole and pyraclostrobin sprays and Hemileia vastatrix infection.

    abstract::Coffee leaf rust (CLR), caused by Hemileia vastatrix, is a major disease affecting coffee production worldwide. In this study, an in-depth analysis of the photosynthetic performance of coffee leaves challenged or not with H. vastatrix and sprayed with either epoxiconazole (EPO) or pyraclostrobin (PYR) was performed by...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Honorato Júnior J,Zambolim L,Aucique-Pérez CE,Resende RS,Rodrigues FA

    更新日期:2015-09-01 00:00:00

  • Overexpression of multiple cytochrome P450 genes associated with sulfoxaflor resistance in Aphis gossypii Glover.

    abstract::Sulfoxaflor is the first commercially available sulfoximine insecticide, which exhibits highly efficacy against many sap-feeding insect pests and has been applied as an alternative insecticide against cotton aphid in China. This study was conducted to investigate the risk of resistance development, the cross-resistanc...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Ma K,Tang Q,Zhang B,Liang P,Wang B,Gao X

    更新日期:2019-06-01 00:00:00

  • Evaluation of antifungal metabolites activity from bacillus licheniformis OE-04 against Colletotrichum gossypii.

    abstract::Anthracnose disease in the cotton plant caused by fungal pathogen Colletotrichum gossypii. It is supposed to be most critical diseases in the cotton crop as it causes infection and leads to complete damaging of the cotton crop by infecting the leaves, stems, and bolls in the field. The disease control is challenging d...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Nawaz HH,Nelly Rajaofera MJ,He Q,Anam U,Lin C,Miao W

    更新日期:2018-04-01 00:00:00

  • Investigations of the constitutive overexpression of CYP6D1 in the permethrin resistantLPR strain of house fly (Musca domestica).

    abstract::House fly (Musca domestica) CYP6D1 is a cytochrome P450 involved in metabolism of xenobiotics. CYP6D1 is located on chromosome 1 and its expression is inducible in response to the prototypical P450 inducer phenobarbital (PB) in insecticide susceptible strains. Increased transcription of CYP6D1 confers resistance to pe...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Lin GG,Scott JG

    更新日期:2011-06-01 00:00:00

  • Single-stranded DNA fragments of insect-specific nuclear polyhedrosis virus act as selective DNA insecticides for gypsy moth control.

    abstract::This paper focuses on the DNA insecticides as a novel preparation against gypsy moth (Lymantria dispar) based on DNA fragments of the anti-apoptotic gene of its nuclear polyhedrosis virus. It was found that the external application of a solution with two single-stranded DNA fragments from BIR and RING domains of LdMNP...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Oberemok VV,Skorokhod OA

    更新日期:2014-07-01 00:00:00

  • Effects of phenazine-1-carboxylic acid on the biology of the plant-pathogenic bacterium Xanthomonas oryzae pv. oryzae.

    abstract::Xanthomonas oryzae pv. oryzae (Xoo) is the casual agent of bacterial blight, which is one of the most serious diseases of rice. The antibiotic phenazine-1-carboxylic acid (PCA), which is primarily produced by Pseudomonas spp., was found and previously reported very effective against Xoo. However, the biological effect...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Xu S,Pan X,Luo J,Wu J,Zhou Z,Liang X,He Y,Zhou M

    更新日期:2015-01-01 00:00:00

  • Reduced neuronal sensitivity and susceptibility of the fall armyworm, Spodoptera frugiperda, to pyrethroids in the absence of known knockdown mutations.

    abstract::Neurophysiological recordings were employed to quantify neuronal sensitivity to neurotoxic insecticides and assessed toxicity across field and laboratory fall armyworm (FAW) populations. Topical toxicity resistance ratios (RR) in field-collected FAW was 767-fold compared to laboratory strains and, importantly, a 1750-...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: McComic SE,Rault LC,Anderson TD,Swale DR

    更新日期:2020-10-01 00:00:00

  • Foliar application of isopyrazam and epoxiconazole improves photosystem II efficiency, biomass and yield in winter wheat.

    abstract::A range of fungicides including epoxiconazole, azoxystrobin and isopyrazam, were applied to winter wheat at GS 31/32 to determine their effect on photosystem II (PSII) efficiency, biomass and yield. Frequent, repeated measurements of chlorophyll fluorescence were carried on plants grown under different water regimes i...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Ajigboye OO,Murchie E,Ray RV

    更新日期:2014-09-01 00:00:00

  • Baseline bio-accumulation concentrations and resulting oxidative stress in Synodontis zambezensis after an acute laboratory exposure to 4,4'-DDT.

    abstract::The use of 1,1'-(2,2,2-Trichloro-1,1-ethanediyl)bis(4-chlorobenzene) (DDT) as a pesticide for the control of insects vectors responsible for the spread of many life threatening diseases was officially banned in 1972 by the United States Environmental Protection Agency (USEPA). It was banned throughout the world, in mo...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Volschenk CM,Ikenaka Y,Yohannes YB,Nakayama SM,Ishizuka M,Smit E,van Vuren JHJ,Greenfield R

    更新日期:2019-05-01 00:00:00

  • Effects of s-metolachlor on early life stages of marbled crayfish.

    abstract::The effects of s-metolachlor chronic exposure at concentrations of 1.1 μg/L (maximal real environmental concentration in the Czech Republic), 11 μg/L (environmental relevant concentration) and 110 μg/L on early life stages of marbled crayfish (Procambarus virginalis) was evaluated under laboratory conditions. All s-me...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Velisek J,Stara A,Zuskova E,Kubec J,Buric M,Kouba A

    更新日期:2019-01-01 00:00:00

  • Entomotoxic activity of Rhinella icterica (Spix, 1824) toad skin secretion in Nauphoeta cinerea cockroaches: An octopamine-like modulation.

    abstract::Rhinella icterica is a poisonous toad whose toxic secretion has never been studied against entomotoxic potential. Sublethal doses of Rhinella icterica toxic secretion (RITS) were assayed in Nauphoeta cinerea cockroaches, in order to understand the physiological and behavioral parameters, over the insect central and pe...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Leal AP,Oliveira RS,Perin APA,Borges BT,de Brum Vieira P,Dos Santos TG,Vinadé L,Valsecchi C,Belo CAD

    更新日期:2018-06-01 00:00:00

  • Novel aryloxyphenoxypropionate derivates containing benzofuran moiety: Design, synthesis, herbicidal activity, docking study and theoretical calculation.

    abstract::A series of novel aryloxyphenoxypropionate (APP) herbicides containing benzofuran moiety were designed, synthesized and tested for herbicidal activity. The bioassay results indicated that most of target compounds possessed moderate to good herbicidal activity against monocotyledonous weeds. Compounds 5a-5d and 6a-6d s...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Yan Z,Yang Z,Deng X,Lin D,Wu M,Li J,Chen A,Ye J,Hu A,Liao H

    更新日期:2019-02-01 00:00:00

  • Activation of biochemical factors in CMV-infected tobacco by ningnanmycin.

    abstract::Cucumber mosaic virus (CMV) is a plant virus with one of the largest host ranges, the widest distribution, and economic importance, and ningnanmycin (NNM) is a commercial antiviral agent. Studies have shown that NNM induces and promotes pathogenesis-related proteins in tobacco mosaic virus-inoculated tobacco. In the p...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Gao D,Wang D,Chen K,Huang M,Xie X,Li X

    更新日期:2019-05-01 00:00:00

  • A novel function of sanshools: the alleviation of injury from metolachlor in rice seedlings.

    abstract::Szechuan peppers are extensively used as a spice and in traditional medicine in Asia, primarily because of its active compounds, sanshools (S). However, there is only limited mention in agriculture, and there are no papers reporting its use as an herbicide safener. In this study, we provide the first evidence that S c...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章


    authors: Tang X,Zhou X,Wu J,Li J,Bai L

    更新日期:2014-03-01 00:00:00

  • Recent advances in tenuazonic acid as a potential herbicide.

    abstract::Tenuazonic acid (TeA), belonging to tetramic acids that are the largest family of natural products, is a mycotoxin produced by members of the genus Alternaria and other phytopathogenic fungi. TeA has many desirable bioactivities. In the past two decades, several studies have addressed its phytotoxic activity. Because ...

    journal_title:Pesticide biochemistry and physiology

    pub_type: 杂志文章,评审


    authors: Chen S,Qiang S

    更新日期:2017-11-01 00:00:00