Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action.

Abstract:

:The aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for drimenol. For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC50 values of 80, 92, 80 and 314ppm, respectively. These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80ppm of drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed.

journal_name

Pestic Biochem Physiol

authors

Robles-Kelly C,Rubio J,Thomas M,Sedán C,Martinez R,Olea AF,Carrasco H,Taborga L,Silva-Moreno E

doi

10.1016/j.pestbp.2016.11.006

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

50-56

eissn

0048-3575

issn

1095-9939

pii

S0048-3575(16)30190-0

journal_volume

141

pub_type

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