Abstract：
:The aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for drimenol. For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC50 values of 80, 92, 80 and 314ppm, respectively. These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80ppm of drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Robles-Kelly C,Rubio J,Thomas M,Sedán C,Martinez R,Olea AF,Carrasco H,Taborga L,Silva-Moreno Edoi
10.1016/j.pestbp.2016.11.006subject
Has Abstractpub_date
2017-09-01 00:00:00pages
50-56eissn
0048-3575issn
1095-9939pii
S0048-3575(16)30190-0journal_volume
141pub_type
杂志文章abstract：:Tetramycin is a novel polyene antibiotic that has exhibited excellent inhibitory activity against many plant pathogens. In this study, the sensitivity of Corynespora cassiicola to tetramycin was assessed in vitro using a series of 91 isolates, and its effects on hyphae and conidia were evaluated. Preventive and curati...
journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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