Abstract：
:Glyphosate (GLP) is one of the most common herbicides worldwide. The serum cholinesterase (ChE) may be affected when exposed to glyphosate. Reduction of serum ChE by herbicides is probably related to cytochrome P450 (CYP450) family polymorphisms. We suspect that the abnormal ChE caused by GLP could be correlated with the CYP family members. To determine whether CYP1B1 (rs1056827 and rs1056836) and CYP1A1 (rs1048943) gene polymorphisms and individual susceptibility to GLP-induced ChE abnormalities were interrelated in the Chinese Han population, we performed this genetic association study on a total of 230 workers previously exposed to GLP, including 115 cases with reduced serum ChE and 115 controls with normal serum ChE. Two even groups of cases and controls were enrolled. The CYP1A1 and CYP1B1 polymorphisms in both groups were genotyped using TaqMan. Subjects with the CYP1A1 rs619586 genotypes showed an increased risk of GLP-induced reduction of serum ChE, which was more evident in the following subgroups: female, > 35 years old, history of GLP exposure time <10 years and >10 years, nonsmoker and nondrinker. The results show that CYP1A1 rs619586 was significantly associated with the GLP-induced reduction in serum ChE and could be a biomarker of susceptibility for Chinese GLP exposed workers. Because of a large number of people exposed to glyphosate, this study has a significance in protecting their health.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Cai W,Zhang F,Zhong L,Chen D,Guo H,Zhang H,Zhu B,Liu Xdoi
10.1016/j.pestbp.2019.07.006subject
Has Abstractpub_date
2020-01-01 00:00:00pages
23-28eissn
0048-3575issn
1095-9939pii
S0048-3575(19)30402-Xjournal_volume
162pub_type
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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journal_title：Pesticide biochemistry and physiology
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