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Natural history and predictors of survival in progressive supranuclear palsy.

Abstract：

BACKGROUND:Progressive supranuclear palsy is a neurodegenerative disorder characterized by high functional disability and rapidly progressive dependency. The predictors of survival are still unclear. METHODS:The predictors of survival were evaluated in a group of clinically diagnosed PSP patients, focusing primarily on extensive cognitive assessment. RESULTS:The mean survival time from symptom onset was 8.25±3.0years. Sex, age at onset, education, occupation and severity of extrapyramidal symptoms did not correlate with survival. The only factor associated with a shorter life expectancy in our cohort was the presence of dementia at diagnosis. Impairment of executive functions was the best predictor of an unfavorable outcome. CONCLUSIONS:Our findings suggest that dementia and executive functions need to be evaluated in order to define survival probability in PSP patients.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Cosseddu M,Benussi A,Gazzina S,Manes MA,Dell'Era V,Cristillo V,Turrone R,Alberici A,Borroni B

doi

10.1016/j.jns.2017.09.043

subject

Has Abstract

pub_date

2017-11-15 00:00:00

pages

105-107

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(17)34349-6

journal_volume

382

pub_type

杂志文章

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