Analysis of fibrogenic processes in denervated tissues of spinal cord injury patients.

Abstract:

:To test the hypothesis that altered collagen metabolism is a contributing factor in the apparent delayed wound healing in denervated regions of spinal cord injury (SCI) patients, a tissue implant (PVA) was used to directly measure collagen deposition. Sterile PVA implants were placed subcutaneously in the inner aspect of the upper arm above the cord injury (innervated) and in the inner aspect of the upper leg below the cord injury (denervated) of 20 spinal cord injury patients and compared to eight healthy volunteers. On day 14, the implants were removed and analyzed histologically by trichrome stain and biochemically for hydroxyproline as a measure of collagen deposition. No remarkable histologic differences were observed in the sponge material removed from the upper regions compared to the lower denervated regions of the spinal cord injury patients. Sponges from both areas were infiltrated with fibroblasts containing well-developed rough endoplasmic reticulum and large quantities of trichrome-positive collagen. Likewise, upper and lower histology of controls was identical and nondistinguishable from the corresponding sections obtained from the spinal cord injury patients. Quantitation of the hydroxyproline in the arms of the spinal cord injury patients (n = 20) showed 4.3 +/- 0.7 nmol hydroxyproline per milligram of sponge compared to 4.1 +/- 0.4 nmol/mg in the denervated regions of the lower limb. The hydroxyproline content in the arms of control volunteers was 5.2 +/- 0.7 nmol/mg compared to 3.9 +/- 0.8 nmol/mg in the leg (n = 8). These observations suggest that fibrogenic processes in denervated regions are not reduced significantly compared to innervated regions.

journal_name

Plast Reconstr Surg

authors

Diegelmann RF,Lindblad WJ,Hussey RW,Maygarden SJ,Cohen IK

doi

10.1097/00006534-198902000-00019

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

309-14

issue

2

eissn

0032-1052

issn

1529-4242

journal_volume

83

pub_type

杂志文章
  • APACHE II scoring for the prediction of immediate surgical complications in head and neck cancer patients.

    abstract:BACKGROUND:Aggressive surgical treatment of oral and oropharyngeal cancers may be compromised by significant surgical complications. Early identification of patients at risk for postoperative complications may assist in clinical decision-making. The objective of this study was to assess the value of the Acute Physiolog...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000259038.36210.f8

    authors: Grant CA,Dempsey GA,Lowe D,Brown JS,Vaughan ED,Rogers SN

    更新日期:2007-05-01 00:00:00

  • Grafting the alar rim: application as anatomical graft.

    abstract:BACKGROUND:Alar rim contour and alar rim grafts have become essential components of rhinoplasty. Ideally, grafts of the nose should be anatomical in shape. So doing might make grafts of the alar rim more robust. The authors considered doing that by applying the graft as a continuous extension of the lateral crus. METH...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000764

    authors: Gruber RP,Fox P,Peled A,Belek KA

    更新日期:2014-12-01 00:00:00

  • Evaluation of three surgical techniques for advancement of the midface in growing children with syndromic craniosynostosis.

    abstract:BACKGROUND:The purpose of this study was to compare clinical outcomes and 1-year postsurgical stability with three different techniques of Le Fort III midface advancement. METHODS:The records of 212 syndromic craniosynostosis patients were reviewed from the period 1973 to 2006. A total of 60 patients satisfied the inc...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181e6051e

    authors: Shetye PR,Davidson EH,Sorkin M,Grayson BH,McCarthy JG

    更新日期:2010-09-01 00:00:00

  • Dermal substitution in acute burns and reconstructive surgery: a subjective and objective long-term follow-up.

    abstract::Tissue engineering and dermal substitution are currently prominent topics of wound-healing research. However, no extensive clinical trials with objective evaluation criteria have been published so far that support the clinical effectiveness of dermal equivalents in the long term. The dermal substitute that is discusse...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006534-200112000-00014

    authors: van Zuijlen PP,Vloemans JF,van Trier AJ,Suijker MH,van Unen E,Groenevelt F,Kreis RW,Middelkoop E

    更新日期:2001-12-01 00:00:00

  • Aneurysmal bone cyst of the orbit associated with fibrous dysplasia.

    abstract::Aneurysmal bone cyst is a rare but recognized osseous lesion of the orbit. We report the presentation, treatment, and postoperative course of an orbital aneurysmal bone cyst in a patient with McCune-Albright syndrome. To our knowledge, this report represents the first description of aneurysmal bone cyst of the orbit i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199508000-00029

    authors: Lucarelli MJ,Bilyk JR,Shore JW,Rubin PA,Yaremchuk MJ

    更新日期:1995-08-01 00:00:00

  • The V-Y advancement myotarsocutaneous flap for upper eyelid reconstruction.

    abstract::The V-Y advancement myotarsocutaneous flap was used to avoid excessive scarring during reconstruction of a full-thickness upper eyelid defect following surgical excision of a malignant tumor. This method has a number of advantages: It has a short operative time, it is a one-stage procedure, it does not require lining ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199709001-00025

    authors: Okada E,Iwahira Y,Maruyama Y

    更新日期:1997-09-01 00:00:00

  • Subcutaneous mastectomy in small, large, or ptotic breasts with immediate submuscular placement of implants.

    abstract::We present a series of 70 patients who have had bilateral subcutaneous mastectomies with immediate placement of implants under the intact pectoralis major and upper part of the serratus anterior. Twenty-two of these patients have had a simultaneous mastopexy, with a free nipple graft. All 70 patients have both of thei...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197811000-00006

    authors: Jarrett JR,Cutler RG,Teal DF

    更新日期:1978-11-01 00:00:00

  • Correction of lower eyelid ptosis in the anophthalmic orbit: a long-term follow-up.

    abstract::We describe a 10-year review of 53 patients having had correction of lower eyelid ptosis using fascia lata sling suspension by the operation first described in 1973. The overall conclusion is that this continues to be a reliable procedure with a low complication rate. Four major changes relating to operative technique...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198309000-00001

    authors: Nolan WB 3rd,Vistnes LM

    更新日期:1983-09-01 00:00:00

  • Bipedicle paraspinous muscle flaps for spinal wound closure: an anatomic and clinical study.

    abstract::The purpose of this study was to evaluate the vascular anatomy of the paraspinous muscles and review their clinical use as bipedicled flaps in spinal wound closure. Anatomically, through cadaver dissections, lead oxide injections, and radiographic imaging, the blood supply to the paraspinous muscles was determined. Cl...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200011000-00011

    authors: Wilhelmi BJ,Snyder N,Colquhoun T,Hadjipavlou A,Phillips LG

    更新日期:2000-11-01 00:00:00

  • Adipose-Derived Stem Cells and Ceiling Culture-Derived Preadipocytes Cultured from Subcutaneous Fat Tissue Differ in Their Epigenetic Characteristics and Osteogenic Potential.

    abstract:BACKGROUND:Adipose-derived stem cells and ceiling culture-derived preadipocytes can be harvested from subcutaneous adipose tissue. Little is known about the epigenetic differences, which may contribute to differences in osteogenic potential, between these cell types. The purpose of this study was to address the osteoge...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005913

    authors: Sasahara Y,Kubota Y,Kosaka K,Adachi N,Yamaji Y,Nagano H,Akita S,Kuroda M,Tanaka T,Bujo H,Mitsukawa N

    更新日期:2019-09-01 00:00:00

  • A modified keyhole technique for correction of macroglossia.

    abstract::The enlarged tongue, or macroglossia, may compromise vital function to the point that surgical correction is necessary. Although earlier procedures simply aimed at reducing tongue bulk, contemporary techniques attempt to decrease lingual dimension yet preserve critical neurosensory function. Still, modern approaches a...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e31818cc3ab

    authors: Kaufman Y,Cole P,McKnight A,Hatef DA,Hollier L,Edmonds J

    更新日期:2008-12-01 00:00:00

  • Age-dependent closure of bony defects after frontal orbital advancement.

    abstract:BACKGROUND:The ability of the immature skull to spontaneously heal large bony defects created after craniofacial procedures was examined over a 25-year period of craniofacial surgery at the Children's Hospital of Philadelphia. METHODS:Only patients who underwent frontal orbital advancement and reconstruction, had at l...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000232353.44086.af

    authors: Paige KT,Vega SJ,Kelly CP,Bartlett SP,Zakai E,Jawad AF,Stouffer N,Whitaker LA

    更新日期:2006-09-15 00:00:00

  • Improvement of patency in small veins following dextran and/or low-molecular-weight heparin treatment.

    abstract::A clinical dose of dextran 70 had significant antithrombotic effects in small, severely traumatized veins, and the effect was enhanced by the addition of low-molecular-weight heparin. These effects were achieved without bleeding problems in this model. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199408000-00021

    authors: Zhang B,Wieslander JB

    更新日期:1994-08-01 00:00:00

  • Reverse dorsal digital island flap.

    abstract::The anatomic and clinical bases for a reliable and versatile homodigital flap for covering difficult distal dorsal and dorsolateral wounds of the long fingers are presented. This one-step procedure, which uses the dorsal skin of the first or second phalanx transposed as a reverse island flap, preserving the collateral...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Bene MD,Petrolati M,Raimondi P,Tremolada C,Muset A

    更新日期:1994-03-01 00:00:00

  • Phenotypically unusual combined craniosynostoses: presentation and management.

    abstract:BACKGROUND:Although most craniosynostoses can be determined by pattern recognition, some patients defy phenotypic diagnosis and require computed tomography to determine sutural fusions. METHODS:The authors' craniofacial database was reviewed for patients treated for craniosynostosis between 1989 and 2007. Children wit...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31817f45f0

    authors: Greene AK,Mulliken JB,Proctor MR,Meara JG,Rogers GF

    更新日期:2008-09-01 00:00:00

  • Three-dimensional analysis and classification of arteries in the skin and subcutaneous adipofascial tissue by computer graphics imaging.

    abstract::To develop new types of surgical flaps that utilize portions of the skin and subcutaneous tissue (e.g., a thin flap or an adipofascial flap), three-dimensional investigation of the vasculature in the skin and subcutaneous tissue has been anticipated. In the present study, total-body arterial injection and three-dimens...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199809030-00020

    authors: Nakajima H,Minabe T,Imanishi N

    更新日期:1998-09-01 00:00:00

  • Triplicated thumb.

    abstract::A polydactyly anomaly of the thumb with three nails, two metacarpals, and seven phalanges is presented. This anomaly is named triplicated thumb, and its place in Wassel's classification is discussed. The patient was treated according to the principles of surgery of polydactyly anomalies. Good motor function with accep...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199708000-00023

    authors: Atabay K,Latifoglu O,Demirkan F,Yavuzer R

    更新日期:1997-08-01 00:00:00

  • Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience.

    abstract:BACKGROUND:The treatment of lentigo maligna and lentigo maligna melanoma presents a difficult problem for clinicians. Published guidelines recommend a 5-mm excision margin for lentigo maligna and a 1-cm margin for lentigo maligna melanoma, yet these are often inadequate. The authors' purpose is to report their 10-year ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181bcf002

    authors: Bosbous MW,Dzwierzynski WW,Neuburg M

    更新日期:2009-12-01 00:00:00

  • Satisfaction with breast reconstruction in women with bilateral prophylactic mastectomy: a descriptive study.

    abstract::Prophylactic bilateral mastectomy is an option for women who are at an increased risk of developing breast cancer. Prophylactic mastectomy is often performed with immediate reconstruction (i.e., at the same time and under the same anesthetic as the mastectomy). Satisfaction with reconstruction has been described previ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000131877.52740.0e

    authors: Metcalfe KA,Semple JL,Narod SA

    更新日期:2004-08-01 00:00:00

  • The use of epidurals in abdominal wall reconstruction: an analysis of outcomes and cost.

    abstract:BACKGROUND:Ventral hernias are a common, challenging, and expensive problem for general and reconstructive surgeons. The authors assessed the impact of epidurals on morbidity following abdominal wall reconstruction for hernia. METHODS:A retrospective review of abdominal wall reconstruction patients operated on between...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000438048.91139.31

    authors: Fischer JP,Nelson JA,Wes AM,Wink JD,Yan C,Braslow BM,Chen L,Kovach SJ

    更新日期:2014-03-01 00:00:00

  • Comparison between rapid and slow tissue expansion in breast reconstruction.

    abstract::Fifty women scheduled for breast reconstruction surgery with tissue expansion were randomly divided into two groups. In the first group the tissue was expanded rapidly, i.e., once a day, starting 1 week postoperatively, and in the other group it was expanded slowly, i.e., once a week, starting after 2 weeks. The expan...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Wickman M

    更新日期:1993-04-01 00:00:00

  • Computer-assisted three-dimensional planning in craniofacial surgery.

    abstract::Three-dimensional surface reconstruction from computed tomographic (CT) data has been used to plan craniofacial operations. Cephalometric and anthropometric databases were integrated with three-dimensional CT reconstructions to quantitate the skeletal deformity and to assist in the design of the surgical procedure. In...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Altobelli DE,Kikinis R,Mulliken JB,Cline H,Lorensen W,Jolesz F

    更新日期:1993-09-01 00:00:00

  • Enhancing the take of injected adipose tissue by a simple method for concentrating fat cells.

    abstract::Injection of aspirated fat for the correction of tissue defects is a common procedure in plastic surgery. The reported rates of fat cell survival vary greatly in the medical literature, and different techniques of harvesting, processing, and reinjecting the fat cells are claimed to be responsible for these differences...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Ramon Y,Shoshani O,Peled IJ,Gilhar A,Carmi N,Fodor L,Risin Y,Ullmann Y

    更新日期:2005-01-01 00:00:00

  • Digital two-dimensional photogrammetry: a comparison of three techniques of obtaining digital photographs.

    abstract::Three methods of obtaining digital photographs in a clinical setting were compared using direct anthropometry as a reference standard. The methods included a digital camera, scanning negatives from a 35-mm single-lens reflex camera, and scanning Polaroid photographs taken with a Polaroid camera designed for medical do...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199906000-00002

    authors: Nechala P,Mahoney J,Farkas LG

    更新日期:1999-06-01 00:00:00

  • Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective study.

    abstract:BACKGROUND:Lymphedema is a common and debilitating condition. Management options for lymphedema are limited and controversial. The purpose of this prospective study was to provide a preliminary analysis of lymphaticovenular bypass for the treatment of upper limb lymphedema in breast cancer patients. METHODS:Twenty pat...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181e5f6a9

    authors: Chang DW

    更新日期:2010-09-01 00:00:00

  • Effects of sodium pentobarbital anesthesia on blood flow in skin, myocutaneous, and fasciocutaneous flaps in swine.

    abstract::Drug effect on flap blood flow is most commonly determined in anesthetized animals, yet the effect of the anesthetic is often poorly understood. Halothane and nitrous oxide cause profound changes in skin blood flow and thus provide an unsuitable anesthetic technique for use in measuring drug effects on skin and myocut...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199108000-00016

    authors: Thomson JG,Kerrigan CL,Abrahamowicz M

    更新日期:1991-08-01 00:00:00

  • Lymph Flow Restoration after Tissue Replantation and Transfer: Importance of Lymph Axiality and Possibility of Lymph Flow Reconstruction without Lymph Node Transfer or Lymphatic Anastomosis.

    abstract:BACKGROUND:The lymph system plays important roles in maintaining fluid balances, the immune system, and lipid metabolism. After tissue replantation or transfer, some cases suffer long-lasting edema or lymphedema caused by interruption of main lymph flows; however, this mechanism has yet to be clarified. METHODS:The me...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000004694

    authors: Yamamoto T,Iida T,Yoshimatsu H,Fuse Y,Hayashi A,Yamamoto N

    更新日期:2018-09-01 00:00:00

  • Demonstration of actin in the fibroblasts of healing palatal wounds.

    abstract::The purpose of this study was to gain information which might be helpful in understanding the influence of palate surgery on abnormal maxillary growth. The finding of actin-rich cells in the granulation tissue of palatal wounds supports the hypothesis that one of the functions of those cells is contraction--and the la...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197809000-00015

    authors: Dabelsteen E,Kremenak CR

    更新日期:1978-09-01 00:00:00

  • Retrobulbar hemorrhage.

    abstract::Retrobulbar hemorrhage is a rare complication of orbital trauma or surgery. Although the process is usually self-limiting, infrequently visual impairment may result. Various methods for relieving the associated intraocular hypertension (caused by the extraocular compression posteriorly) have been suggested. The effect...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197701000-00007

    authors: Huang TT,Horwitz B,Lewis SR

    更新日期:1977-01-01 00:00:00

  • Reconstruction of breast asymmetry in Poland's chest-wall deformity using microvascular free flaps.

    abstract::Poland's syndrome comprises a spectrum of chest-wall deformities affecting, to various degrees, the rib cage, the chest-wall muscles, the neurovascular structures of the ipsilateral arm, and the overlying breast. This study details our experience with nine female Poland's syndrome patients who had chest-wall and breas...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199702000-00017

    authors: Longaker MT,Glat PM,Colen LB,Siebert JW

    更新日期:1997-02-01 00:00:00